Mechanism of modulation of single sodium channels from skeletal muscle by the ? 1-subunit from rat brain

1994 ◽  
Vol 426 (3-4) ◽  
pp. 360-362 ◽  
Author(s):  
Wolfgang Schreibmayer ◽  
Martin Wallner ◽  
Ilana Lotan
Keyword(s):  
Skeletal Muscle ◽  
Rat Brain ◽  
Sodium Channels ◽  
Single Sodium Channels

Single sodium channels from rat brain incorporated into planar lipid bilayer membranes

Nature ◽  
1983 ◽  
Vol 303 (5913) ◽  
pp. 172-175 ◽  
Author(s):  
Bruce K. Krueger ◽  
Jennings F. Worley ◽  
Robert J. French
Keyword(s):  
Rat Brain ◽  
Lipid Bilayer ◽  
Sodium Channels ◽  
Planar Lipid Bilayer ◽  
Lipid Bilayer Membranes ◽  
Bilayer Membranes ◽  
Single Sodium Channels

scholarly journals Identification of Soluble Protein Phosphatases That Dephosphorylate Voltage-sensitive Sodium Channels in Rat Brain

1995 ◽  
Vol 270 (13) ◽  
pp. 7750-7756 ◽  
Author(s):  
Tzu-chin Chen ◽  
Brian Law ◽  
Tamara Kondratyuk ◽  
Sandra Rossie
Keyword(s):  
Rat Brain ◽  
Sodium Channels ◽  
Soluble Protein ◽  
Protein Phosphatases

MicroO-conotoxin MrVIA inhibits mammalian sodium channels, but not through site I

1996 ◽  
Vol 76 (3) ◽  
pp. 1423-1429 ◽  
Author(s):  
H. Terlau ◽  
M. Stocker ◽  
K. J. Shon ◽  
J. M. McIntosh ◽  
B. M. Olivera
Keyword(s):  
Rat Brain ◽  
Sodium Channels ◽  
Xenopus Oocytes ◽  
Electric Organ ◽  
Hill Coefficient ◽  
Inactivation Kinetics ◽  
Type Ii ◽  
Amino Acid Peptide ◽  
Voltage Gated Sodium Channels ◽  
Dependent Inhibition

1. A 31-amino-acid peptide from the venom of the snail-hunting species Conus marmoreus, microO-conotoxin MrVIA, inhibits mammalian voltage-gated sodium channels through a novel mechanism distinct from saxitoxin, tetrodotoxin, or mu-conotoxin. 2. MicroO-Conotoxin MrVIA blocks rat brain type II sodium channels expressed in Xenopus oocytes (IC50 approximately 200 nM, Hill coefficient approximately 1.6 +/- 0.2, mean +/- SE). Channel activation/inactivation kinetics and current-voltage relationships were unperturbed. 3. MicroO-Conotoxin MrVIA does not cause phasic or use-dependent inhibition of sodium currents measured in Xenopus oocytes expressing rat brain type II sodium channels, but shifts the steady-state availability of these sodium channels to more hyperpolarized potentials. 4. MicroO-Conotoxin MrVIA inhibited rapidly inactivating sodium channel conductance in rat hippocampal cells in culture. The inhibition was rapidly reversible. 5. MicroO-Conotoxin MrVIA does not displace specific [3H]saxitoxin binding to either rat brain or Electrophorus electric organ sites, indicating inhibitory effects mediated through a binding site distinct from site I.

scholarly journals Design of a Specific Activator for Skeletal Muscle Sodium Channels Uncovers Channel Architecture

2007 ◽  
Vol 282 (40) ◽  
pp. 29424-29430 ◽  
Author(s):  
Lior Cohen ◽  
Nitza Ilan ◽  
Maya Gur ◽  
Walter Stühmer ◽  
Dalia Gordon ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Sodium Channels ◽  
Channel Architecture

Patch clamp characterization of sodium channels expressed from rat brain cDNA

1987 ◽  
Vol 14 (3) ◽  
pp. 131-138 ◽  
Author(s):  
W. Stühmer ◽  
C. Methfessel ◽  
B. Sakmann ◽  
M. Noda ◽  
S. Numa
Keyword(s):  
Patch Clamp ◽  
Rat Brain ◽  
Sodium Channels
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