Lack of correlation between mdr-1 expression and volume-activation of cloride-currents in rat colon cancer cells

1995 ◽  
Vol 430 (2) ◽  
pp. 296-298 ◽  
Author(s):  
C. De Greef ◽  
S. van der Heyden ◽  
F. Viana ◽  
J. Eggermont ◽  
E. A. De Bruijn ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Rat Colon ◽  
Colon Cancer Cells ◽  
Volume Activation ◽  
Mdr 1

scholarly journals Deacetylase Plus Bromodomain Inhibition Downregulates ERCC2 and Suppresses the Growth of Metastatic Colon Cancer Cells

Cancers ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1438
Author(s):  
Sabeeta Kapoor ◽  
Trace Gustafson ◽  
Mutian Zhang ◽  
Ying-Shiuan Chen ◽  
Jia Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Excision Repair ◽  
Critical Role ◽  
Rat Colon ◽  
Precision Oncology ◽  
Metastatic Colon Cancer ◽  
Colon Cancer Cells ◽  
Combination Drug ◽  
Human Colon Cancer

There is growing evidence that DNA repair factors have clinical value for cancer treatment. Nucleotide excision repair (NER) proteins, including excision repair cross-complementation group 2 (ERCC2), play a critical role in maintaining genome integrity. Here, we examined ERCC2 expression following epigenetic combination drug treatment. Attention was drawn to ERCC2 for three reasons. First, from online databases, colorectal cancer (CRC) patients exhibited significantly reduced survival when ERCC2 was overexpressed in colon tumors. Second, ERCC2 was the most highly downregulated RNA transcript in human colon cancer cells and rat tumors after treatment with the histone deacetylase 3 (HDAC3) inhibitor sulforaphane (SFN) plus JQ1, which is an inhibitor of the bromodomain and extraterminal domain (BET) family. Third, as reported here, RNA-sequencing of polyposis in rat colon (Pirc) polyps following treatment of rats with JQ1 plus 6-methylsulfinylhexyl isothiocyanate (6-SFN) identified Ercc2 as the most highly downregulated gene. The current work also defined promising second-generation epigenetic drug combinations with enhanced synergy and efficacy, especially in metastasis-lineage colon cancer cells cultured as 3D spheroids and xenografts. This investigation adds to the growing interest in combination approaches that target epigenetic ‘readers’, ‘writers’, and ‘erasers’ that are deregulated in cancer and other pathologies, providing new avenues for precision oncology and cancer interception.

scholarly journals Sinomenine Sensitizes Multidrug-Resistant Colon Cancer Cells (Caco-2) to Doxorubicin by Downregulation of MDR-1 Expression

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e98560 ◽  
Author(s):  
Zhen Liu ◽  
Zhi-Jun Duan ◽  
Jiu-Yang Chang ◽  
Zhi-feng Zhang ◽  
Rui Chu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Multidrug Resistant ◽  
Colon Cancer Cells ◽  
Mdr 1

MDR-1-overexpression in HT 29 colon cancer cells grown in SCID mice

2012 ◽  
Vol 114 (6) ◽  
pp. 594-602 ◽  
Author(s):  
Udo Schumacher ◽  
Nina Nehmann ◽  
Elizabeth Adam ◽  
Dhia Mukthar ◽  
Itzchak N. Slotki ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Scid Mice ◽  
Colon Cancer Cells ◽  
Ht 29 ◽  
Mdr 1

Effects of fatty acids on liver metastasis of ACL‐15 rat colon cancer cells

1998 ◽  
Vol 31 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Shigeyoshi Iwamoto ◽  
Hideto Senzaki ◽  
Yasuhiko Kiyozuka ◽  
Eliko Ogura ◽  
Hideho Takada ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Colon Cancer ◽  
Liver Metastasis ◽  
Cancer Cells ◽  
Rat Colon ◽  
Colon Cancer Cells

Selection by trypsin of two sublines of rat colon cancer cells forming progressive or regressive tumors

1983 ◽  
Vol 32 (5) ◽  
pp. 623-627 ◽  
Author(s):  
François Martin ◽  
Anne Caignard ◽  
Jean-François Jeannin ◽  
Annick Leclerc ◽  
Monique Martin
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Rat Colon ◽  
Colon Cancer Cells

scholarly journals Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells

Oncogene ◽  
2001 ◽  
Vol 20 (51) ◽  
pp. 7478-7485 ◽  
Author(s):  
Sandeep Gurbuxani ◽  
Jean-Marie Bruey ◽  
Annie Fromentin ◽  
Nicolas Larmonier ◽  
Arnaud Parcellier ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Rat Colon ◽  
Colon Cancer Cells ◽  
Selective Depletion

scholarly journals Retraction: Sinomenine Sensitizes Multidrug-Resistant Colon Cancer Cells (Caco-2) to Doxorubicin by Downregulation of MDR-1 Expression

PLoS ONE ◽  
2019 ◽  
Vol 14 (4) ◽  
pp. e0215388
Author(s):  
Zhen Liu ◽  
Zhi-Jun Duan ◽  
Jiu-Yang Chang ◽  
Zhi-feng Zhang ◽  
Rui Chu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Multidrug Resistant ◽  
Colon Cancer Cells ◽  
Mdr 1

Abnormal basement membrane in tumors induced by rat colon cancer cells

1994 ◽  
Vol 107 (3) ◽  
pp. 701-711 ◽  
Author(s):  
Philippe Pujuguet ◽  
Arlette Hammann ◽  
François Martin ◽  
Monique Martin
Keyword(s):  
Colon Cancer ◽  
Basement Membrane ◽  
Cancer Cells ◽  
Rat Colon ◽  
Colon Cancer Cells
Sign in / Sign up

Export Citation Format

Share Document