Contribution of potassium accumulation in narrow extracellular spaces to the genesis of nicorandil-induced large inward tail current in guinea-pig ventricular cells

1993 ◽  
Vol 422 (4) ◽  
pp. 371-379 ◽  
Author(s):  
K. Yasui ◽  
T. Anno ◽  
K. Kamiya ◽  
M. R. Boyett ◽  
I. Kodama ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Potassium Accumulation ◽  
Tail Current ◽  
Ventricular Cells

scholarly journals Involvement of A pertussis Toxin Sensitive G-Protein in the Inhibition of Inwardly Rectifying K+Currents by Platelet-Activating Factor in Guinea-Pig Atrial Cardiomyocytes

1994 ◽  
Vol 3 (1) ◽  
pp. 45-51
Author(s):  
M. Gollasch ◽  
T. Kleppisch ◽  
D. Krautwurst ◽  
D. Lewinsohn ◽  
J. Hescheler
Keyword(s):  
Cyclic Amp ◽  
Guinea Pig ◽  
G Protein ◽  
Pertussis Toxin ◽  
Platelet Activating Factor ◽  
Resting Membrane Potential ◽  
Patch Clamp Technique ◽  
Guinea Pig Heart ◽  
Ventricular Cells ◽  
Inwardly Rectifying

Platelet-activating factor (PAF) inhibits single inwardly rectifying K+channels in guinea-pig ventricular cells. There is currently little information as to the mechanism by which these channels are modulated. The effect of PAF on quasi steady-state inwardly rectifying K+currents (presumably of the IK1type) of auricular, atrial and ventricular cardiomyocytes from guinea-pig were studied. Applying the patch-clamp technique in the whole-cell configuration, PAF (10 nM) reduced the K+currents in all three cell types. The inhibitory effect of PAF occurred within seconds and was reversible upon wash-out. It was almost completely abolished by the PAF receptor antagonist BN 50730. Intracellular infusion of atrial cells with guanine 5′-(β-thio)diphosphate (GDPS) or pretreatment of cells with pertussis toxin abolished the PAF dependent reduction of the currents. Neither extracellularly applied isoproterenol nor intracellularly applied adenosine 3′,5′-cyclic monophosphate (cyclic AMP) attenuated the PAF effect. In multicellular preparations of auricles, PAF (10 nM) induced arrhythmias. The arrhythmogenic activity was also reduced by BN 50730. The data indicate that activated PAF receptors inhibit inwardly rectifying K+currents via a pertussis toxin sensitive G-protein without involvement of a cyclic AMP-dependent step. Since IK1is a major component in stabilizing the resting membrane potential, the observed inhibition of this type of channel could play an important role in PAF dependent arrhythmogenesis in guinea-pig heart.

Background current, i, in guinea-pig ventricular cells

1992 ◽  
Vol 24 ◽  
pp. 269
Author(s):  
T Kiyosue ◽  
AJ Spindler ◽  
SJ Noble ◽  
D Noble
Keyword(s):  
Guinea Pig ◽  
Background Current ◽  
Ventricular Cells

scholarly journals Interaction of the Na+-K+pump and Na+-Ca2+exchange via [Na+]iin a restricted space of guinea-pig ventricular cells

1998 ◽  
Vol 509 (2) ◽  
pp. 457-470 ◽  
Author(s):  
Yasutada Fujioka ◽  
Satoshi Matsuoka ◽  
Toshihiko Ban ◽  
Akinori Noma
Keyword(s):  
Guinea Pig ◽  
Ventricular Cells

scholarly journals Changes in Membrane Potentials and Currents of Ventricular Cells of the Guinea Pig Heart by a New Cardiotonic Drug, MCI-154

1987 ◽  
Vol 44 (4) ◽  
pp. 481-488
Author(s):  
Sohta KATAYAMA ◽  
Akihiro NARIMATSU ◽  
Reiko SUZUKI ◽  
Toshihiko IIJIMA ◽  
Norio TAIRA
Keyword(s):  
Guinea Pig ◽  
Membrane Potentials ◽  
Guinea Pig Heart ◽  
Ventricular Cells ◽  
Cardiotonic Drug
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