Identification of T-cell receptor V ? deletion mutant mouse strain AU/ssJ (H-2 q ) which is resistant to collagen-induced arthritis

1989 ◽  
Vol 29 (3) ◽  
pp. 180-185 ◽  
Author(s):  
Tariq M. Haqqi ◽  
Subhashis Banerjee ◽  
Wendy L. Jones ◽  
Gary Anderson ◽  
Mark A. Behlke ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Mouse Strain ◽  
Deletion Mutant ◽  
Mutant Mouse ◽  
Cell Receptor ◽  
Collagen Induced Arthritis ◽  
Mutant Mouse Strain

Restricted T cell receptor usage in DA rats during early collagen-induced arthritis

1994 ◽  
Vol 24 (8) ◽  
pp. 1929-1932 ◽  
Author(s):  
Helena Erlandsson ◽  
Åsa Müsseneru ◽  
Lars Klareskogu ◽  
Daniel P. Goldf
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Collagen Induced Arthritis ◽  
Receptor Usage

scholarly journals Depletion of alpha/beta T cells by a monoclonal antibody against the alpha/beta T cell receptor suppresses established adjuvant arthritis, but not established collagen-induced arthritis in rats.

1992 ◽  
Vol 175 (4) ◽  
pp. 907-915 ◽  
Author(s):  
S Yoshino ◽  
L G Cleland
Keyword(s):  
Monoclonal Antibody ◽  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Adjuvant Arthritis ◽  
Inflammatory Cells ◽  
Cell Receptor ◽  
Collagen Induced Arthritis ◽  
Alpha Beta ◽  
Synovial Tissues

The effects of treatment with a monoclonal antibody (R73 mAb) against T cell receptor alpha/beta (TCR-alpha/beta) on both established adjuvant arthritis (EAA) and established collagen-induced arthritis (ECIA) in rats have been investigated. Rats were treated with R73 mAb when arthritis reached a peak. Treatment with the anti-TCR-alpha/beta mAb markedly suppressed EAA, whereas ECIA was not affected by the mAb treatment. Histologically, R73 mAb-treated rats with EAA showed mild hyperplasia of synovial tissues, sparse infiltration of inflammatory cells, and minimal erosion of cartilage, whereas arthritic rats treated with PBS and an irrelevant control mAb against Giardia had marked hyperplasia of synovium with pannus, massive inflammatory cell infiltrate, and severe destruction of cartilage and subchondral bone. R73 mAb-treated rats with ECIA exhibited pronounced formation of pannus containing many inflammatory cells and marked cartilage and subchondral damage similar to those in arthritic rats that received the control treatments. Treatment with R73 mAb depleted markedly alpha/beta+ T cells in both peripheral blood and synovial tissues of rats with EAA and ECIA. R73 mAb treatment was associated with marked reduction in arthritogen-specific delayed-type hypersensitivity responses in both EAA and ECIA. The titers of antibodies against type II collagen produced in rats with ECIA were not affected by the mAb. Thus, alpha/beta+ T cells appear to have a central role in EAA, but not in chronic ECIA.

Effects of Various Anti-T Cell Receptor Antibodies on the Development of Type II Collagen-Induced Arthritis in Mice

1993 ◽  
Vol 22 (4) ◽  
pp. 257-265 ◽  
Author(s):  
Joanne T. Hom ◽  
Thomas Estridge ◽  
Harlan Cole ◽  
Virginia Gliszczynski ◽  
Alison Bendele
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Type Ii Collagen ◽  
Cell Receptor ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Receptor Antibodies

Restricted T-Cell Receptor Usage in DA Rats during Early Collagen-Induced Arthritis

1995 ◽  
Vol 756 (1 T-Cell Recept) ◽  
pp. 225-226
Author(s):  
H. ERLANDSSON ◽  
Å. MÜSSENER ◽  
L. KLARESKOG ◽  
D. P. GOLD
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Collagen Induced Arthritis ◽  
Receptor Usage

Abrogation of the Allelic Exclusion in a T Cell Receptor β Chain Gene Transgenic Mouse Strain

1995 ◽  
Vol 24 (6) ◽  
pp. 927-946 ◽  
Author(s):  
O. Mazda ◽  
Y. Aiba ◽  
N. Hattori ◽  
M. Li ◽  
S. Fujimoto ◽  
...  
Keyword(s):  
T Cell ◽  
Transgenic Mouse ◽  
T Cell Receptor ◽  
Mouse Strain ◽  
Cell Receptor ◽  
Chain Gene ◽  
Allelic Exclusion ◽  
Transgenic Mouse Strain ◽  
Β Chain
Sign in / Sign up

Export Citation Format

Share Document