A calcium-dependent component of the action potential in sympathetic nerve terminals in rat tail artery

1991 ◽  
Vol 418 (1-2) ◽  
pp. 102-108 ◽  
Author(s):  
P. �strand ◽  
L. Stj�rne
Keyword(s):  
Action Potential ◽  
Sympathetic Nerve ◽  
Nerve Terminals ◽  
Rat Tail Artery ◽  
Tail Artery ◽  
Calcium Dependent ◽  
Dependent Component ◽  
Rat Tail

Effects of STZ-diabetes on noradrenaline and NPY concentration in sympathetic nerve terminals in the rat tail artery

2007 ◽  
Vol 135 (1-2) ◽  
pp. 73-74
Author(s):  
John F.B. Morrison ◽  
Rajan Sheen ◽  
Subramanian Dhanasekaran
Keyword(s):  
Sympathetic Nerve ◽  
Nerve Terminals ◽  
Rat Tail Artery ◽  
Tail Artery ◽  
Rat Tail

Hydrallazine: Mode of Action at the Neuroarterial Junction

1980 ◽  
Vol 59 (s6) ◽  
pp. 445s-447s ◽  
Author(s):  
C. Chevillard ◽  
B. Saiag ◽  
M. Worcel
Keyword(s):  
Wistar Rats ◽  
Direct Action ◽  
Nerve Terminals ◽  
Rat Tail Artery ◽  
Experimental Conditions ◽  
Tail Artery ◽  
Marked Inhibition ◽  
6 Hydroxydopamine ◽  
Rat Tail

1. Hydrallazine relaxes the rat tail artery by a direct action on vascular smooth muscle cells, which appears to be modulated by the action of sympathetic nerve terminals. 2. There is a gradient of response to hydrallazine in arteries from normotensive Wistar rats, the proximal segments being poorly responsive. This gradient disappears after denervation with 6-hydroxydopamine in vitro. 3. Exogenously added purines inhibit noncompetitively the vasodilator response to hydrallazine in denervated segments from normotensive Wistar rats. Their order of potency is 2-Cl-adenosine > adenosine > ATP > inosine. 4. The effect of hydrallazine in innervated, poorly responsive segments is greatly potentiated by theophylline (50 μmol/l) and propranolol (5 μmol/l). These results, together with the effect of denervation, suggest that there are endogenous purines leaking from the nerve terminals under our experimental conditions. 5. Hydrallazine produces a marked inhibition of stimulus-induced contraction and 3H release after [3H]noradrenaline loading. The mechanism of this prejunctional action appears to be different from the mechanism of the postjunctional effect.

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