Characterization of acetylcholine- and endothelin-induced calcium entry in cultured human ciliary muscle cells

1992 ◽  
Vol 422 (2) ◽  
pp. 105-111 ◽  
Author(s):  
Frank Stahl ◽  
Barbara Gebauer ◽  
Albrecht Lepple-Wienhues ◽  
Gunhild Langenbeck-Groh ◽  
Susanne Berweck ◽  
...  
Keyword(s):  
Muscle Cells ◽  
Calcium Entry ◽  
Ciliary Muscle

scholarly journals Characterization of Cytoskeleton-Enriched Protein Fraction of the Trabecular Meshwork and Ciliary Muscle Cells

2010 ◽  
Vol 51 (12) ◽  
pp. 6461 ◽  
Author(s):  
Toshihiro Inoue ◽  
Paula Pecen ◽  
Rupalatha Maddala ◽  
Nikolai P. Skiba ◽  
Padmanabhan P. Pattabiraman ◽  
...  
Keyword(s):  
Trabecular Meshwork ◽  
Protein Fraction ◽  
Muscle Cells ◽  
Ciliary Muscle

scholarly journals 3P213 Characterization of calcium response of cultured bovine ciliary muscle cells to muscarinic stimulation

2005 ◽  
Vol 45 (supplement) ◽  
pp. S257
Author(s):  
M. Miyazu ◽  
H. Ohinata ◽  
Y. Takai ◽  
A. Takai
Keyword(s):  
Muscle Cells ◽  
Ciliary Muscle ◽  
Calcium Response ◽  
Muscarinic Stimulation

scholarly journals Synthesis and Characterization of Store-Operated Calcium Entry Inhibitors Active in the Submicromolar Range

2020 ◽  
Vol 21 (24) ◽  
pp. 9777
Author(s):  
Camille Le Guilcher ◽  
Tomas Luyten ◽  
Jan B. Parys ◽  
Mathieu Pucheault ◽  
Olivier Dellis
Keyword(s):  
Cell Activation ◽  
Interleukin 2 ◽  
Calcium Entry ◽  
Ip3 Receptors ◽  
Excitable Cells ◽  
Cellular Targets ◽  
Entry Inhibitors ◽  
The Past ◽  
Store Operated Calcium Entry

The store-operated calcium entry, better known as SOCE, forms the main Ca2+ influx pathway in non-excitable cells, especially in leukocytes, where it is required for cell activation and the immune response. During the past decades, several inhibitors were developed, but they lack specificity or efficacy. From the non-specific SOCE inhibitor 2-aminoethyl diphenylborinate (2-APB), we synthetized 16 new analogues by replacing/modifying the phenyl groups. Among them, our compound P11 showed the best inhibitory capacity with a Ki ≈ 75 nM. Furthermore, below 1 µM, P11 was devoid of any inhibitory activity on the two other main cellular targets of 2-APB, the IP3 receptors, and the SERCA pumps. Interestingly, Jurkat T cells secrete interleukin-2 under phytohemagglutinin stimulation but undergo cell death and stop IL-2 synthesis when stimulated in the presence of increasing P11 concentrations. Thus, P11 could represent the first member of a new and potent family of immunosuppressors.

Pharmacological and Functional Characterization of Bradykinin Receptors in Rat Cultured Vascular Smooth Muscle Cells

1999 ◽  
Vol 11 (12) ◽  
pp. 853-862 ◽  
Author(s):  
Chuen-Mao Yang ◽  
Yih-Jeng Tsai ◽  
Shiow-Lin Pan ◽  
Wen-Bin Wu ◽  
Chuan-Chwan Wang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Vascular Smooth Muscle Cells ◽  
Functional Characterization ◽  
Muscle Cells ◽  
Bradykinin Receptors

Effect of Latanoprost Acid and Pilocarpine on Cultured Rabbit Ciliary Muscle Cells

2007 ◽  
Vol 39 (4) ◽  
pp. 232-240 ◽  
Author(s):  
Yisheng Zhong ◽  
Jian Gao ◽  
Wen Ye ◽  
Ping Huang ◽  
Yu Cheng ◽  
...  
Keyword(s):  
Muscle Cells ◽  
Ciliary Muscle

Characterization of β-adrenoceptors on rat skeletal muscle cells grown in vitro

1990 ◽  
Vol 40 (5) ◽  
pp. 1043-1048 ◽  
Author(s):  
Marie-Helene Disatnik ◽  
Sanford R. Sampson ◽  
Asher Shainberg
Keyword(s):  
Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Rat Skeletal Muscle
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