A model of cell firing patterns during epileptic seizures

1976 ◽  
Vol 22 (4) ◽  
pp. 229-234 ◽  
Author(s):  
L. K. Kaczmarek
Keyword(s):  
Epileptic Seizures ◽  
Firing Patterns ◽  
Cell Firing

Grids from bands, or bands from grids? An examination of the effects of single unit contamination on grid cell firing fields

2016 ◽  
Vol 115 (2) ◽  
pp. 992-1002 ◽  
Author(s):  
Z. Navratilova ◽  
K. B. Godfrey ◽  
B. L. McNaughton
Keyword(s):  
Single Cell ◽  
Grid Cell ◽  
Cell Isolation ◽  
Recording Technology ◽  
Firing Patterns ◽  
Limiting Step ◽  
Isolation Methods ◽  
Single Cell Isolation ◽  
Cell Firing ◽  
Cell Data

Neural recording technology is improving rapidly, allowing for the detection of spikes from hundreds of cells simultaneously. The limiting step in multielectrode electrophysiology continues to be single cell isolation. However, this step is crucial to the interpretation of data from putative single neurons. We present here, in simulation, an illustration of possibly erroneous conclusions that may be reached when poorly isolated single cell data are analyzed. Grid cells are neurons recorded in rodents, and bats, that spike in equally spaced locations in a hexagonal pattern. One theory states that grid firing patterns arise from a combination of band firing patterns. However, we show here that summing the grid firing patterns of two poorly resolved neurons can result in spurious band-like patterns. Thus, evidence of neurons spiking in band patterns must undergo extreme scrutiny before it is accepted. Toward this aim, we discuss single cell isolation methods and metrics.

scholarly journals Hippocampal Place Cell Firing Patterns Can Induce Long-Term Synaptic Plasticity In Vitro

2009 ◽  
Vol 29 (21) ◽  
pp. 6840-6850 ◽  
Author(s):  
J. T. R. Isaac ◽  
K. A. Buchanan ◽  
R. U. Muller ◽  
J. R. Mellor
Keyword(s):  
Synaptic Plasticity ◽  
Place Cell ◽  
Firing Patterns ◽  
Cell Firing ◽  
Hippocampal Place Cell

Remapping of place cell firing patterns after maze rotations

2002 ◽  
Vol 143 (4) ◽  
pp. 470-479 ◽  
Author(s):  
Arnaud Cressant ◽  
Robert U. Muller ◽  
Bruno Poucet
Keyword(s):  
Place Cell ◽  
Firing Patterns ◽  
Cell Firing

scholarly journals Effect of Interictal Spikes on Single-Cell Firing Patterns in the Hippocampus

Epilepsia ◽  
2007 ◽  
Vol 48 (4) ◽  
pp. 720-731 ◽  
Author(s):  
Jun-Li Zhou ◽  
Pierre-Pascal Lenck-Santini ◽  
Qian Zhao ◽  
Gregory L. Holmes
Keyword(s):  
Single Cell ◽  
Interictal Spikes ◽  
Firing Patterns ◽  
Cell Firing

Functional Significance of Cannabinoid-Mediated, Depolarization-Induced Suppression of Inhibition (DSI) in the Hippocampus

2003 ◽  
Vol 90 (1) ◽  
pp. 55-64 ◽  
Author(s):  
Robert E. Hampson ◽  
Shou-yuan Zhuang ◽  
Jeff L. Weiner ◽  
Sam A. Deadwyler
Keyword(s):  
Hippocampal Neurons ◽  
Hippocampal Slices ◽  
Memory Task ◽  
Short Term ◽  
Firing Patterns ◽  
Pulse Trains ◽  
Hippocampal Cell ◽  
Gabaergic Synapses ◽  
Cell Firing

A number of recent studies have demonstrated that a well-known form of short-term plasticity at hippocampal GABAergic synapses, called depolarization-induced suppression of inhibition (DSI), is in fact mediated by the retrograde actions of endocannabinoids released in response to depolarization of the postsynaptic cells. These studies suggest that endogenous cannabinoids may play an important role in regulating inhibitory tone in the mammalian CNS. Despite the widespread interest and potential physiological importance of DSI, many questions regarding the physiological relevance of DSI remain. To that end, this study set out to define the specific limiting conditions that could elicit DSI at GABAergic synapses in CA1 hippocampal pyramidal neurons and to determine if DSI could be elicited with pulse trains that mimic hippocampal cell-firing patterns that occur in vivo. Whole cell recordings from hippocampal neurons under voltage-clamp configuration were made in rat hippocampal slices. Spontaneous and evoked γ-aminobutyric acid-A (GABAA) receptor-mediated inhibitory postsynaptic currents (sIPSCs and eIPSCs, respectively) were recorded prior to and following depolarization of CA1 hippocampal pyramidal cells. Depolarizing voltage pulses were shaped to evoke currents in QX-314-treated cells similar to those accompanying single spontaneous voltage-clamped action potentials recorded from the soma. Attempts were made to elicit DSI with trains of these pulses that mimicked hippocampal cell firing patterns in vivo, for instance, when animals traverse place fields or are performing a short-term memory task. DSI could not be elicited by such pulse trains or by a number of other combinations of behaviorally specific firing parameters. The minimum duration of depolarization necessary to elicit DSI in hippocampal neurons determined by paired-pulse manipulation was 50 –75 ms at a critical interval of 20 –30 ms between pulse pairs. Under the conditions tested, the normal firing patterns of hippocampal neurons that occur in vivo do not appear to elicit DSI.

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