Linkage mapping of the apolipoprotein A-I (APOA1) gene to pig Chromosome 9

1994 ◽  
Vol 5 (1) ◽  
pp. 58-59 ◽  
Author(s):  
H. Ellegren
Keyword(s):  
Linkage Mapping ◽  
Chromosome 9 ◽  
Apoa1 Gene ◽  
Apolipoprotein A

Identification of a Human LMX1 (LMX1.1)-Related Gene, LMX1.2: Tissue-Specific Expression and Linkage Mapping on Chromosome 9

Genomics ◽  
1997 ◽  
Vol 46 (3) ◽  
pp. 520-524 ◽  
Author(s):  
Christopher A. Iannotti ◽  
Hiroshi Inoue ◽  
Ernesto Bernal ◽  
Minoru Aoki ◽  
Li Liu ◽  
...  
Keyword(s):  
Linkage Mapping ◽  
Chromosome 9 ◽  
Related Gene ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

Linkage mapping of the apolipoprotein A-I gene to bovine Chromosome 15

1996 ◽  
Vol 7 (7) ◽  
pp. 561-561
Author(s):  
H. Sundvold ◽  
H. Klungland ◽  
D. I. Våge ◽  
S. Lien
Keyword(s):  
Linkage Mapping ◽  
Bovine Chromosome ◽  
Chromosome 15 ◽  
Apolipoprotein A ◽  
I Gene

Linkage mapping of ovine cysteine and histidine-rich protein gene (CYHR1) to chromosome 9

2004 ◽  
Vol 35 (3) ◽  
pp. 263-264 ◽  
Author(s):  
J. H. Calvo ◽  
S. Marcos ◽  
A. E. Beattie ◽  
J. J. Jurado ◽  
M. Serrano
Keyword(s):  
Linkage Mapping ◽  
Protein Gene ◽  
Chromosome 9

P0349A MISSPROCESSED FORM OF APOLIPOPROTEIN A-I IS SPECIFICALLY ASSOCIATED TO RECURRENT FOCAL SEGMENTAL GLOMERULOSCLEROSIS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Conxita Jacobs Cachá ◽  
Natàlia Puig Gay ◽  
Dominic Helm ◽  
Mandy Rettel ◽  
Joana Sellares ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amino Acids ◽  
At Risk ◽  
Clinical Laboratory ◽  
Mass Spectrometry Analysis ◽  
2D Electrophoresis ◽  
Spectrometry Analysis ◽  
Apoa1 Gene ◽  
Apolipoprotein A ◽  
Patients At Risk

Abstract Background and Aims Recurrence of idiopathic FSGS, a glomerular disease of unknown aetiology, is a serious complication after kidney transplantation. There are no accurate means to diagnose the relapses or to detect the patients at risk. In an exploratory study we detected Apolipoprotein A-Ib (ApoA-Ib), a high molecular weight form of ApoA-I, specifically in urine of kidney transplanted patients that relapsed of FSGS. The diagnostic performance of ApoA-Ib has been assessed in two independent cohorts obtaining high specificity (94,1 %) and sensitivity (87,5 %) to detect FSGS relapses. It has also a potential to detect patients at risk of relapse as ApoA-Ib predates the recurrence episodes in most of the cases. As urinary ApoA-Ib is strongly associated to primary FSGS we aimed to unravel the nature of the modification present in ApoA-Ib. Method The whole APOA1 gene was sequenced in ApoA-Ib positive and negative patients and the protein structure was studied using 2D electrophoresis followed by mass spectrometry. Results No genetic variations in the APOA1 gene were found in the ApoA-Ib positive patients that could explain the increase in the molecular mass. The mass spectrometry analysis revealed three extra amino acids at the N-Terminal end of ApoA-Ib that were not present in the standard plasmatic form of ApoA-I. These amino acids corresponded to half of the propeptide sequence of the immature form of ApoA-I (proApoA-I). These results suggest that proApoA-I is miss-cleaved producing ApoA-Ib probably due to an altered protease activity in recurrent FSGS patients Conclusion ApoA-Ib, found specifically in urine of recurrent FSGS patients, is a misprocessed form of ApoA-I that retains three aminoacids of the six-aminoacid N-terminal propeptide of proApoA-I. The description of ApoA-Ib could be relevant not only to allow the automated analysis of this biomarker in the clinical laboratory but also to shed light into the molecular mechanism of idiopathic FSGS.

The porcine sarcolipin (SLN) gene: identification of an SNP and linkage mapping to chromosome 9

2001 ◽  
Vol 32 (2) ◽  
pp. 109-110 ◽  
Author(s):  
L. Fontanesi ◽  
R. Davoli ◽  
J. Milc ◽  
V. Russo
Keyword(s):  
Linkage Mapping ◽  
Chromosome 9 ◽  
Gene Identification

Linkage mapping of the α-B-crystallin (CRYAB ) gene to porcine chromosome 9

2000 ◽  
Vol 31 (4) ◽  
pp. 287-288 ◽  
Author(s):  
L Fontanesi ◽  
R Davoli ◽  
J Milc ◽  
V Russo
Keyword(s):  
Linkage Mapping ◽  
Chromosome 9 ◽  
Porcine Chromosome
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