Large scale production of recombinant mouse and rat growth hormone by fed-batch GS-NSO cell cultures

1996 ◽  
Vol 22 (1-3) ◽  
pp. 239-250 ◽  
Author(s):  
Weichang Zhou ◽  
Theodora Bibila ◽  
Konstantin Glazomitsky ◽  
Javier Montalyo ◽  
Christine Chan ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cell Cultures ◽  
Large Scale ◽  
Scale Production ◽  
Fed Batch ◽  
Recombinant Mouse ◽  
Large Scale Production ◽  
Rat Growth

Large-Scale Production of Glaciozyma antarctica Antifreeze Protein 1 (Afp1) by Fed-Batch Fermentation of Pichia pastoris

2017 ◽  
Vol 43 (1) ◽  
pp. 133-141 ◽  
Author(s):  
Mahzan Md Tab ◽  
Noor Haza Fazlin Hashim ◽  
Nazalan Najimudin ◽  
Nor Muhammad Mahadi ◽  
Farah Diba Abu Bakar ◽  
...  
Keyword(s):  
Pichia Pastoris ◽  
Batch Fermentation ◽  
Large Scale ◽  
Antifreeze Protein ◽  
Scale Production ◽  
Fed Batch ◽  
Large Scale Production ◽  
Fed Batch Fermentation

scholarly journals Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture

2019 ◽  
Author(s):  
Natalie Rubio ◽  
Isha Datar ◽  
David Stachura ◽  
Kate Krueger
Keyword(s):  
Cell Culture ◽  
Cell Cultures ◽  
Closed System ◽  
Biomedical Engineering ◽  
Large Scale ◽  
Fish Cell ◽  
Scale Production ◽  
Animal Cells ◽  
Large Scale Production ◽  
Physiological Properties

Cellular agriculture is defined as the production of agricultural products from cell cultures rather than from whole plants or animals. With growing interest in cellular agriculture as a means to address the public health, environmental, and animal welfare challenges of animal agriculture, the concept of producing seafood from fish cell- and tissue-cultures is emerging as a means to address similar challenges with industrial aquaculture systems and marine capture. Cell-based seafood - as opposed to animal-based seafood - can combine developments in biomedical engineering with modern aquaculture techniques. Biomedical engineering developments such as closed-system bioreactor production of land animal cells create a basis for large scale production of marine animal cells. Aquaculture techniques such as genetic modification and closed system aquaculture have achieved marked gains in production that can pave the way for innovations in cell-based seafood production. Here, we present the current state of innovation relevant to the development of cell-based seafood across multiple species as well as specific opportunities and challenges that exist for advancing this science. The authors find that the physiological properties of fish cell- and tissue- culture may be uniquely suited to cultivation in vitro. These physiological properties, including hypoxia tolerance, high buffering capacity, and low-temperature growth conditions, make marine cell culture an attractive opportunity for scale production of cell-based seafood; perhaps even more so than mammalian and avian cell cultures for cell-based meats. This, coupled with the unique capabilities of crustacean tissue-friendly scaffolding such as chitosan, a common seafood waste product and mushroom derivative, presents great promise for cell-based seafood production via bioreactor cultivation. To become fully realized, cell-based seafood research will require more understanding of fish muscle culture and cultivation; more investigation into serum-free media formulations optimized for fish cell culture; and bioreactor designs tuned to the needs of fish cells for large scale production.

scholarly journals Segmented linear modeling of CHO fed-batch culture and its application to large scale production

2016 ◽  
Vol 114 (4) ◽  
pp. 785-797 ◽  
Author(s):  
Bassem Ben Yahia ◽  
Boris Gourevitch ◽  
Laetitia Malphettes ◽  
Elmar Heinzle
Keyword(s):  
Batch Culture ◽  
Large Scale ◽  
Scale Production ◽  
Fed Batch ◽  
Linear Modeling ◽  
Large Scale Production ◽  
Fed Batch Culture

scholarly journals Cell-Based Fish: A Novel Approach to Seafood Production and an Opportunity for Cellular Agriculture

2018 ◽  
Author(s):  
Natalie Rubio ◽  
Isha Datar ◽  
David Stachura ◽  
Kate Krueger
Keyword(s):  
Cell Culture ◽  
Cell Cultures ◽  
Closed System ◽  
Biomedical Engineering ◽  
Large Scale ◽  
Fish Cell ◽  
Scale Production ◽  
Animal Cells ◽  
Large Scale Production ◽  
Physiological Properties

Cellular agriculture is defined as the production of agricultural products from cell cultures rather than from whole plants or animals. With growing interest in cellular agriculture as a means to address the public health, environmental, and animal welfare challenges of animal agriculture, the concept of producing seafood from fish cell- and tissue-cultures is emerging as a means to address similar challenges with industrial aquaculture systems and marine capture. Cell-based seafood - as opposed to animal-based seafood - can combine developments in biomedical engineering with modern aquaculture techniques. Biomedical engineering developments such as closed-system bioreactor production of land animal cells create a basis for large scale production of marine animal cells. Aquaculture techniques such as genetic modification and closed system aquaculture have achieved marked gains in production that can pave the way for innovations in cell-based seafood production. Here, we present the current state of innovation relevant to the development of cell-based seafood across multiple species as well as specific opportunities and challenges that exist for advancing this science. The authors find that the physiological properties of fish cell- and tissue- culture may be uniquely suited to cultivation in vitro. These physiological properties, including hypoxia tolerance, high buffering capacity, and low-temperature growth conditions, make marine cell culture an attractive opportunity for scale production of cell-based seafood; perhaps even more so than mammalian and avian cell cultures for cell-based meats. This, coupled with the unique capabilities of crustacean tissue-friendly scaffolding such as chitosan, a common seafood waste product and mushroom derivative, presents great promise for cell-based seafood production via bioreactor cultivation. To become fully realized, cell-based seafood research will require more understanding of fish muscle culture and cultivation; more investigation into serum-free media formulations optimized for fish cell culture; and bioreactor designs tuned to the needs of fish cells for large scale production.

Sign in / Sign up

Export Citation Format

Share Document