scholarly journals Chromosomal localization of the zinc finger protein 15, Zfp15, on Mouse Chromosome 4

1995 ◽  
Vol 6 (4) ◽  
pp. 305-305 ◽  
Author(s):  
M. L. Roller ◽  
S. A. Camper
Keyword(s):  
Mouse Chromosome ◽  
Zinc Finger ◽  
Chromosomal Localization ◽  
Zinc Finger Protein ◽  
Chromosome 4 ◽  
Finger Protein

scholarly journals Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene

1989 ◽  
Vol 17 (24) ◽  
pp. 10427-10438 ◽  
Author(s):  
Kamal Chowdhury ◽  
Susanne Dietrich ◽  
Rudi Balling ◽  
Jean-Louis Guenet ◽  
Peter Gruss
Keyword(s):  
Zinc Finger ◽  
Protein Gene ◽  
Chromosomal Localization ◽  
Zinc Finger Protein ◽  
Zinc Finger Protein Gene ◽  
Finger Protein

scholarly journals KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Gernot Wolf ◽  
Alberto de Iaco ◽  
Ming-An Sun ◽  
Melania Bruno ◽  
Matthew Tinkham ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Zinc Finger Protein ◽  
Current Model ◽  
Gene Clusters ◽  
Chromosome 2 ◽  
Chromosome 4 ◽  
Zinc Finger Protein Gene ◽  
Finger Protein ◽  
Retrotransposon Activity ◽  
Large Clusters

The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerged to suppress TEs. We demonstrate that many recently emerged murine KRAB-ZFPs also bind to TEs, including the active ETn, IAP, and L1 families. Using a CRISPR/Cas9-based engineering approach, we genetically deleted five large clusters of KRAB-ZFPs and demonstrate that target TEs are de-repressed, unleashing TE-encoded enhancers. Homozygous knockout mice lacking one of two KRAB-ZFP gene clusters on chromosome 2 and chromosome 4 were nonetheless viable. In pedigrees of chromosome 4 cluster KRAB-ZFP mutants, we identified numerous novel ETn insertions with a modest increase in mutants. Our data strongly support the current model that recent waves of retrotransposon activity drove the expansion of KRAB-ZFP genes in mice and that many KRAB-ZFPs play a redundant role restricting TE activity.

Chromosomal localization of zinc finger protein genes in man and mouse

Genomics ◽  
1989 ◽  
Vol 4 (3) ◽  
pp. 323-327 ◽  
Author(s):  
Alan Ashworth ◽  
Brenda P. Williams ◽  
Arthur M. Buchberg ◽  
Peter N. Goodfellow ◽  
Ellen Solomon ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Chromosomal Localization ◽  
Zinc Finger Protein ◽  
Finger Protein

Chromosomal localization of a gene, GF11 encoding a novel zinc finger protein reveals a new syntenic region between man and rodents

1995 ◽  
Vol 70 (3-4) ◽  
pp. 263-267 ◽  
Author(s):  
D.W. Bell ◽  
T. Taguchi ◽  
N.A. Jenkins ◽  
D.J. Gilbert ◽  
N.G. Copeland ◽  
...  
Keyword(s):  
Zinc Finger ◽  
Chromosomal Localization ◽  
Zinc Finger Protein ◽  
Syntenic Region ◽  
Finger Protein
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