The role of melanocyte-stimulating hormone (MSH) receptor in bovine coat color determination

1995 ◽  
Vol 6 (9) ◽  
pp. 636-639 ◽  
Author(s):  
H. Klungland ◽  
D. I. Vage ◽  
L. Gomez-Raya ◽  
S. Adalsteinsson ◽  
S. Lien
Keyword(s):  
Coat Color ◽  
Melanocyte Stimulating Hormone ◽  
Color Determination ◽  
Stimulating Hormone

scholarly journals Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, α-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex

1995 ◽  
Vol 305 (2) ◽  
pp. 433-438 ◽  
Author(s):  
S Kapas ◽  
A Purbrick ◽  
J P Hinson
Keyword(s):  
Protein Kinase C ◽  
Angiotensin Ii ◽  
Protein Kinase ◽  
Tyrosine Kinase ◽  
Zona Glomerulosa ◽  
Aldosterone Secretion ◽  
Melanocyte Stimulating Hormone ◽  
Kinase C ◽  
Stimulating Hormone

The role of protein kinases in the steroidogenic actions of alpha-melanocyte-stimulating hormone (alpha-MSH), angiotensin II (AngII) and corticotropin (ACTH) in the rat adrenal zona glomerulosa was examined. Ro31-8220, a potent selective inhibitor of protein kinase C (PKC), inhibited both AngII- and alpha-MSH-stimulated aldosterone secretion but had no effect on aldosterone secretion in response to ACTH. The effect of Ro31-8220 on PKC activity was measured in subcellular fractions. Basal PKC activity was higher in cytosol than in membrane or nuclear fractions. Incubation of the zona glomerulosa with either alpha-MSH or AngII resulted in significant increases in PKC activity in the nuclear and cytosolic fractions and decreases in the membrane fraction. These effects were all inhibited by Ro31-8220. ACTH caused a significant increase in nuclear PKC activity only, and this was inhibited by Ro31-8220 without any significant effect on the steroidogenic response to ACTH, suggesting that PKC translocation in response to ACTH may be involved in another aspect of adrenal cellular function. Tyrosine phosphorylation has not previously been considered to be an important component of the response of adrenocortical cells to peptide hormones. Both AngII and alpha-MSH were found to activate tyrosine kinase, but ACTH had no effect, observations that have not been previously reported. Tyrphostin 23, a specific antagonist of tyrosine kinases, inhibited aldosterone secretion in response to AngII and alpha-MSH, but not ACTH. These data confirm the importance of PKC in the adrenocortical response to AngII and alpha-MSH, and, furthermore, indicate that tyrosine kinase may play a critical role in the steroidogenic actions of AngII and alpha-MSH in the rat adrenal zona glomerulosa.

Analogs of α-melanocyte stimulating hormone with high agonist potency and selectivity at human melanocortin receptor 1b: The role of Trp9 in molecular recognition

Biopolymers ◽  
2008 ◽  
Vol 89 (5) ◽  
pp. 401-408 ◽  
Author(s):  
Maria A. Bednarek ◽  
Tanya MacNeil ◽  
Rui Tang ◽  
Tung M. Fong ◽  
M. Angeles Cabello ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Melanocortin Receptor ◽  
Melanocyte Stimulating Hormone ◽  
Stimulating Hormone

scholarly journals Role of the kidney in regulating plasma immunoreactive beta-melanocyte-stimulating hormone.

BMJ ◽  
1976 ◽  
Vol 1 (6014) ◽  
pp. 874-876 ◽  
Author(s):  
A G Smith ◽  
S Shuster ◽  
A J Thody ◽  
F Alvarez-Ude ◽  
D N Kerr
Keyword(s):  
Melanocyte Stimulating Hormone ◽  
Stimulating Hormone

Role of the anteroventral third ventricle (AV3V) region of the rat brain in the pressor response to γ2-melanocyte-stimulating hormone (γ2-MSH)

1988 ◽  
Vol 444 (1) ◽  
pp. 177-180 ◽  
Author(s):  
Michael F. Callahan ◽  
J.Thomas Cunningham ◽  
Robert F. Kirby ◽  
Alan Kim Johnson ◽  
Kenneth A. Gruber
Keyword(s):  
Rat Brain ◽  
Pressor Response ◽  
Third Ventricle ◽  
Melanocyte Stimulating Hormone ◽  
Stimulating Hormone
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