Sex chromosome loss and non-disjunction in women: Analysis of chromosomal segregation in binucleated lymphocytes

Chromosoma ◽  
1996 ◽  
Vol 104 (6) ◽  
pp. 461-467 ◽  
Author(s):  
Andrea Zijno ◽  
Paola Leopardi ◽  
Francesca Marcon ◽  
Riccardo Crebelli
Keyword(s):  
Sex Chromosome ◽  
Chromosome Loss ◽  
Chromosomal Segregation ◽  
Binucleated Lymphocytes

Sex chromosome loss and non-disjunction in women: Analysis of chromosomal segregation in binucleated lymphocytes

Chromosoma ◽  
1996 ◽  
Vol 104 (6) ◽  
pp. 461-467 ◽  
Author(s):  
Andrea Zijno ◽  
Paola Leopardi ◽  
Francesca Marcon ◽  
Riccardo Crebelli
Keyword(s):  
Sex Chromosome ◽  
Chromosome Loss ◽  
Chromosomal Segregation ◽  
Binucleated Lymphocytes

Sex chromosome loss may represent a disease-associated clonal population in chronic lymphocytic leukemia

2013 ◽  
Vol 53 (3) ◽  
pp. 240-247 ◽  
Author(s):  
Elise Chapiro ◽  
Ileana Antony-Debre ◽  
Nathalie Marchay ◽  
Christophe Parizot ◽  
Claude Lesty ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Sex Chromosome ◽  
Lymphocytic Leukemia ◽  
Chromosome Loss ◽  
Clonal Population

scholarly journals Interrogation of cancer gene dependencies reveals novel paralog interactions of autosome and sex chromosome encoded genes

2021 ◽  
Author(s):  
Anna Köferle ◽  
Andreas Schlattl ◽  
Alexandra Hörmann ◽  
Fiona Spreitzer ◽  
Alexandra M. Popa ◽  
...  
Keyword(s):  
Y Chromosome ◽  
Therapeutic Strategy ◽  
Sex Chromosome ◽  
De Novo ◽  
Chromosome Loss ◽  
Potential Candidate ◽  
Loss Of Function ◽  
Male Patients ◽  
Tumour Cell Lines ◽  
Paralog Gene

Genetic networks are characterized by extensive buffering. During tumour evolution, disruption of these functional redundancies can create de novo vulnerabilities that are specific to cancer cells. In this regard, paralog genes are of particular interest, as the loss of one paralog gene can render tumour cells dependent on a remaining paralog. To systematically identify cancer-relevant paralog dependencies, we searched for candidate dependencies using CRISPR screens and publicly available loss-of-function datasets. Our analysis revealed >2,000 potential candidate dependencies, several of which were subsequently experimentally validated. We provide evidence that DNAJC15-DNAJC19, FAM50A-FAM50B and RPP25-RPP25L are novel cancer relevant paralog dependencies. Importantly, our analysis also revealed unexpected redundancies between sex chromosome genes. We show that chrX- and chrY- encoded paralogs, as exemplified by ZFX-ZFY, DDX3X-DDX3Y and EIF1AX-EIF1AY, are functionally linked so that tumour cell lines from male patients with Y-chromosome loss become exquisitely dependent on the chrX-encoded gene. We therefore propose genetic redundancies between chrX- and chrY- encoded paralogs as a general therapeutic strategy for human tumours that have lost the Y-chromosome.

Monochorionic-diamniotic twins discordant in gender from a naturally conceived pregnancy through postzygotic sex chromosome loss in a 47,XXY zygote

2008 ◽  
Vol 28 (8) ◽  
pp. 759-763 ◽  
Author(s):  
Nicolas H. Zech ◽  
Josef Wisser ◽  
Giancarlo Natalucci ◽  
Mariluce Riegel ◽  
Alessandra Baumer ◽  
...  
Keyword(s):  
Sex Chromosome ◽  
Chromosome Loss

Trisomy 7 and sex chromosome loss in human brain tissue

1989 ◽  
Vol 52 (3-4) ◽  
pp. 136-138 ◽  
Author(s):  
S. Heim ◽  
N. Mandahl ◽  
Y. Jin ◽  
S. Strömblad ◽  
E. Lindström ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Tissue ◽  
Sex Chromosome ◽  
Chromosome Loss ◽  
Human Brain Tissue ◽  
Trisomy 7

2.41 Clinical Significance of Sex Chromosome Loss in Chronic Lymphocytic Leukemia

2011 ◽  
Vol 11 ◽  
pp. S184-S185
Author(s):  
I. Antony-Debré ◽  
N. Marchay ◽  
C. Parizot ◽  
E. Chapiro ◽  
H.A. Cung ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Clinical Significance ◽  
Sex Chromosome ◽  
Lymphocytic Leukemia ◽  
Chromosome Loss

RADIATION INDUCED SEX CHROMOSOME LOSS AS AN INDICATOR OF THE OPTIMAL STAGE DURING SPERMATOGENESIS FOR THE INDUCTION OF COMPOUND CHROMOSOMES IN LUCILIA CUPRINA

1981 ◽  
Vol 23 (1) ◽  
pp. 101-109 ◽  
Author(s):  
R. H. Maddern
Keyword(s):  
Sex Chromosome ◽  
Lucilia Cuprina ◽  
Chromosome Loss ◽  
Pest Species ◽  
Radiation Induced

Radiation induced sex chromosome loss has been used to determine the optimal stage at which to irradiate developing male gonial cells in order to produce compound autosomes. In Lucilia it was found that the optimal stage for inducing sex chromosome loss was correlated with the stage at which the greatest number of radiation induced compound chromosomes was recovered. By analogy with Drosophila the data suggest that the 2 to 3 day old pupa is the earliest stage at which spermatocytes are produced in Lucilia. Using this method it should be possible to determine the optimal age at which to irradiate in order to produce compound chromosomes in other pest species where information relating spermatogenic development to age is limited.

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