Postoperative biosynthetic human growth hormone increases the strength and collagen deposition of experimental colonic anastomoses

1991 ◽  
Vol 6 (3) ◽  
pp. 133-138 ◽  
Author(s):  
Henrik Christensen ◽  
Hans Oxlund ◽  
S�ren Laurberg
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Collagen Deposition ◽  
Colonic Anastomoses

Dose-dependent stimulatory effect of human growth hormone on the strength and collagen deposition of colonic anastomoses in the rat

1992 ◽  
Vol 126 (5) ◽  
pp. 438-443 ◽  
Author(s):  
Henrik Christensen ◽  
Allan Flyvbjerg
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Dry Weight ◽  
Preoperative Treatment ◽  
Collagen Deposition ◽  
Hydroxyproline Content ◽  
Colonic Anastomoses ◽  
Bursting Strength ◽  
Igf I

The effects of treatment with four different doses of biosynthetic human growth hormone (b-hGH; 0.125mg kg−1 d−1, 0.5mg kg−1 d−1, 2.0 mg kg−1 d−1, 8.0 mg kg−1 d−1) on the bursting strength and collagen deposition of rat colonic anastomoses were studied. Rats receiving 2.0mg and 8.0 mg b-hGH demonstrated increases in the pre- and postoperative body weights, and the bursting strength and hydroxyproline content of the anastomotic segments in these groups were significantly higher than controls on day 4 postoperatively. The serum levels of insulin-like growth factor I (IGF-I) were significantly higher than the controls after four days of preoperative treatment in the groups receiving 2.0 mg and 8.0 mg b-hGH, and postoperatively the IGF-I levels were significantly higher than those of the controls in the groups receiving 0.5 mg, 2.0 mg and 8.0 mg b-hGH per kg. Consequently, positive correlations were found between treatment doses of b-hGH and anastomotic defatted dry weight, hydroxyproline content and bursting strength of colonic anastomoses.

LIPOLYTIC ACTIVITY OF ENZYME DIGESTED HUMAN GROWTH HORMONE

1965 ◽  
Vol 49 (3_Suppl) ◽  
pp. S143
Author(s):  
Zvi Laron ◽  
Avivah Kowadlo-Silbergeld
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Lipolytic Activity ◽  
Human Growth

The minimal amino acid sequence of the insulin-potentiating fragments of human growth hormone: its mechanism of action

Diabetes ◽  
1980 ◽  
Vol 29 (10) ◽  
pp. 782-787 ◽  
Author(s):  
F. M. Ng ◽  
J. Bornstein ◽  
C. E. Pullin ◽  
J. O. Bromley ◽  
S. L. Macaulay
Keyword(s):  
Growth Hormone ◽  
Amino Acid ◽  
Amino Acid Sequence ◽  
Human Growth Hormone ◽  
Mechanism Of Action ◽  
Human Growth
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