Serum lactate dehydrogenase (S-LDH) and S-LDH isoenzymes in patients with testicular germ cell tumors

1983 ◽  
Vol 189 (2) ◽  
pp. 326-333 ◽  
Author(s):  
Finn E. von Eyben ◽  
Gunnar Skude ◽  
Sophie D. Fosså ◽  
Olbjørn Klepp ◽  
Ole Børmer
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Ldh Isoenzymes

Serum Lactate Dehydrogenase Isoenzyme 1 and Relapse in Patients with Nonseminomatous Testicular Germ Cell Tumors Clinical Stage I

2001 ◽  
Vol 40 (4) ◽  
pp. 536-540 ◽  
Author(s):  
Finn Edler von Eyben ◽  
Ebbe Lindegaard Madsen ◽  
Ole Blaabjerg ◽  
Per Hyltoft Petersen ◽  
Hans von der Maase ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Clinical Stage ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Stage I ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell ◽  
Dehydrogenase Isoenzyme

Serum lactate dehydrogenase levels in malignant germ cell tumors of ovary

1996 ◽  
Vol 6 (4) ◽  
pp. 328-332 ◽  
Author(s):  
P.S. Patel ◽  
V.M. Sharma ◽  
G.N. Raval ◽  
R.M. Rawal ◽  
M.M. Patel ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Germ Cell ◽  
Germ Cell Tumors ◽  
Serum Lactate ◽  
Serum Lactate Dehydrogenase ◽  
Malignant Germ Cell Tumors

scholarly journals Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1358
Author(s):  
Mette Lorenzen ◽  
John Erik Nielsen ◽  
Christine Hjorth Andreassen ◽  
Anders Juul ◽  
Birgitte Grønkær Toft ◽  
...  
Keyword(s):  
Luteinizing Hormone ◽  
Germ Cell ◽  
Elevated Serum ◽  
Germ Cell Tumors ◽  
Xenograft Model ◽  
Luteinizing Hormone Receptor ◽  
Serum Lactate Dehydrogenase ◽  
Testicular Germ Cell Tumors ◽  
Testicular Germ Cell

Luteinizing hormone/choriogonadotropin receptor (LHCGR) regulates gonadal testosterone production and recent studies have suggested a growth-regulatory role in somatic cancers. Here, we established that LHCGR is expressed in a fraction of seminoma cells and germ cell neoplasia in situ (GCNIS), and the seminoma-derived cell line TCam2 released LHCGR into the medium. LH treatment induced proliferation of TCam2 cells in vitro, while hCG treatment induced a non-significant 51% increase in volume of tumors formed in a TCam2 xenograft model. A specific ELISA was used to detect a soluble LHCGR in serum. Serum concentrations of soluble LHCGR could not distinguish 4 patients with GCNIS and 216 patients with testicular germ cell tumors (TGCTs) from 297 infertile or 148 healthy young men. Instead, serum LHCGR levels were significantly higher in 112 patients with a seminoma >5 cm or elevated serum lactate dehydrogenase (LDH) compared with men harboring smaller seminomas <2 cm or normal LDH levels. Serum LHCGR levels in TGCT patients could not predict relapse irrespective whether determined pre- or post-orchiectomy. Combined, these novel findings suggest that LHCGR may be directly involved in the progression and growth of seminomas, and our retrospective pilot study suggests that serum LHCGR may have some prognostic value in men with seminoma.

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