Overproduction of an antisense RNA containing the oop RNA sequence of bacteriophage λ induces clear plaque formation

1987 ◽  
Vol 210 (1) ◽  
pp. 184-186 ◽  
Author(s):  
Kathy M. Takayama ◽  
Nicole Houba-Herin ◽  
Masayori Inouye
Keyword(s):  
Antisense Rna ◽  
Plaque Formation ◽  
Bacteriophage Λ ◽  
Rna Sequence ◽  
Clear Plaque

scholarly journals Antisense Technology

2019 ◽  
Author(s):  
Mahnoor Patel
Keyword(s):  
Gene Expression ◽  
Nucleic Acid ◽  
Antisense Rna ◽  
Nucleic Acid Sequence ◽  
Base Pairs ◽  
Rna Sequence ◽  
Antisense Technology ◽  
Synthetic Oligonucleotide ◽  
Complementary Sense

Diseases are often connected on the expression of some disease causing gene which is important to produce that Protein. If the expression of this gene can be disputed then the disease can be cured. Antisense technology is a method of disputing the production of protein. It may be used to design some therapeutics for diseases in whose pathology is the production of protein plays a major role. Antisense technology is important tool in the inhibition of that particular gene expression. The principle behind it, is that the antisense nucleic acid sequence base pairs with its complementary sense RNA strand is inserted and prevents the RNA from translated into protein. The complementary nucleic acid sequence is either complementary synthetic oligonucleotide, often oligodeoxy ribonucleotide, or longer antisense RNA sequence.

A Cytochemical Study of Glucose-6-Phosphatase (G-6-PASE) in Cells Participating in Atherogenesis of Rabbit Aorta

1975 ◽  
Vol 33 ◽  
pp. 460-461
Author(s):  
Sidney D. Kobernick ◽  
Edna A. Elfont ◽  
Neddra L. Brooks
Keyword(s):  
Lipid Metabolism ◽  
New Zealand ◽  
Aortic Wall ◽  
Rabbit Aorta ◽  
Plaque Formation ◽  
Metabolic Changes ◽  
Atherosclerotic Plaques ◽  
Cytochemical Study ◽  
Cellular Alteration ◽  
New Zealand White Rabbits

This cytochemical study was designed to investigate early metabolic changes in the aortic wall that might lead to or accompany development of atherosclerotic plaques in rabbits. The hypothesis that the primary cellular alteration leading to plaque formation might be due to changes in either carbohydrate or lipid metabolism led to histochemical studies that showed elevation of G-6-Pase in atherosclerotic plaques of rabbit aorta. This observation initiated the present investigation to determine how early in plaque formation and in which cells this change could be observed.Male New Zealand white rabbits of approximately 2000 kg consumed normal diets or diets containing 0.25 or 1.0 gm of cholesterol per day for 10, 50 and 90 days. Aortas were injected jin situ with glutaraldehyde fixative and dissected out. The plaques were identified, isolated, minced and fixed for not more than 10 minutes. Incubation and postfixation proceeded as described by Leskes and co-workers.

Q-mediated late gene transcription of bacteriophage λ: RNA start point and RNase III processing sites in vivo

Virology ◽  
1988 ◽  
Vol 167 (2) ◽  
pp. 568-577 ◽  
Author(s):  
D DANIELS ◽  
M SUBBARAO ◽  
F BLATTNER ◽  
H LOZERON
Keyword(s):  
Gene Transcription ◽  
Late Gene ◽  
Bacteriophage Λ ◽  
Rnase Iii
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