Structural diversity of the patatin gene family in potato cv. Desiree

1988 ◽  
Vol 212 (2) ◽  
pp. 325-336 ◽  
Author(s):  
David Twell ◽  
Gert Ooms
Keyword(s):  
Gene Family ◽  
Structural Diversity ◽  
Patatin Gene

scholarly journals Structural diversity and functional implications of the eukaryotic TDP gene family

Genomics ◽  
2004 ◽  
Vol 83 (1) ◽  
pp. 130-139 ◽  
Author(s):  
Hurng-Yi Wang ◽  
I-Fan Wang ◽  
Jayaramakrishnan Bose ◽  
C.-K.James Shen
Keyword(s):  
Gene Family ◽  
Structural Diversity ◽  
Functional Implications

scholarly journals Expansion of the dehydrin gene family in the Pinaceae is associated with considerable structural diversity and drought-responsive expression

2017 ◽  
Vol 38 (3) ◽  
pp. 442-456 ◽  
Author(s):  
Juliana Stival Sena ◽  
Isabelle Giguère ◽  
Philippe Rigault ◽  
Jean Bousquet ◽  
John Mackay
Keyword(s):  
Gene Family ◽  
Structural Diversity ◽  
Dehydrin Gene

Functional and structural diversity of the human Dickkopf gene family

Gene ◽  
1999 ◽  
Vol 238 (2) ◽  
pp. 301-313 ◽  
Author(s):  
Valery E. Krupnik ◽  
John D. Sharp ◽  
Chian Jiang ◽  
Keith Robison ◽  
Troy W. Chickering ◽  
...  
Keyword(s):  
Gene Family ◽  
Structural Diversity

scholarly journals Structural Diversity and Differential Transcription of the Patatin Multicopy Gene Family During Potato Tuber Development

Genetics ◽  
2005 ◽  
Vol 172 (2) ◽  
pp. 1263-1275 ◽  
Author(s):  
Robert M. Stupar ◽  
Karen A. Beaubien ◽  
Weiwei Jin ◽  
Junqi Song ◽  
Mi-Kyung Lee ◽  
...  
Keyword(s):  
Potato Tuber ◽  
Gene Family ◽  
Structural Diversity ◽  
Tuber Development ◽  
Multicopy Gene ◽  
Differential Transcription

Evolution of the Integral Membrane Desaturase Gene Family in Moths and Flies

Genetics ◽  
2002 ◽  
Vol 162 (4) ◽  
pp. 1737-1752
Author(s):  
Douglas C Knipple ◽  
Claire-Lise Rosenfield ◽  
Rasmus Nielsen ◽  
Kyung Man You ◽  
Seong Eun Jeong
Keyword(s):  
Gene Family ◽  
Structural Diversity ◽  
Mate Recognition ◽  
Synonymous Substitution ◽  
Recognition System ◽  
Pheromone Biosynthesis ◽  
Primary Role ◽  
Genome Database ◽  
Species Specific ◽  
Pheromone Glands

Abstract Lepidopteran insects use sex pheromones derived from fatty acids in their species-specific mate recognition system. Desaturases play a particularly prominent role in the generation of structural diversity in lepidopteran pheromone biosynthesis as a result of the diverse enzymatic properties they have evolved. These enzymes are homologous to the integral membrane desaturases, which play a primary role in cold adaptation in eukaryotic cells. In this investigation, we screened for desaturase-encoding sequences in pheromone glands of adult females of eight lepidopteran species. We found, on average, six unique desaturase-encoding sequences in moth pheromone glands, the same number as is found in the genome database of the fly, Drosophila melanogaster, vs. only one to three in other characterized eukaryotic genomes. The latter observation suggests the expansion of this gene family in insects before the divergence of lepidopteran and dipteran lineages. We present the inferred homology relationships among these sequences, analyze nonsynonymous and synonymous substitution rates for evidence of positive selection, identify sequence and structural correlates of three lineages containing characterized enzymatically distinct desaturases, and discuss the evolution of this sequence family in insects.

Metal-, and Organocatalyst-Free One-Pot Assembly of Chiral Aza-Tricyclic Molecules: Creating Six Contiguous Stereocenters from 2-D-Structures and an Amino Acid

2020 ◽  
Author(s):  
Dung Do
Keyword(s):  
Amino Acid ◽  
Chemical Space ◽  
Structural Diversity ◽  
Therapeutic Agents ◽  
Chiral Molecules ◽  
One Pot ◽  
Complex Molecules ◽  
Chiral Catalyst ◽  
Chiral Complex ◽  
Free Process

<p>Chiral molecules with their defined 3-D structures are of paramount importance for the study of chemical biology and drug discovery. Having rich structural diversity and unique stereoisomerism, chiral molecules offer a large chemical space that can be explored for the design of new therapeutic agents.<sup>1</sup> Practically, chiral architectures are usually prepared from organometallic and organocatalytic processes where a transition metal or an organocatalyst is tailor-made for desired reactions. As a result, developing a method that enables rapid assembly of chiral complex molecules under metal- and organocatalyst-free condition represents a daunting challenge. Here we developed a straightforward route to create a chiral 3-D structure from 2-D structures and an amino acid without any chiral catalyst. The center of this research is the design of a <a>special chiral spiroimidazolidinone cyclohexadienone intermediate</a>, a merger of a chiral reactive substrate with multiple nucleophillic/electrophillic sites and a transient organocatalyst. <a>This unique substrate-catalyst (“subcatalyst”) dual role of the intermediate enhances </a><a>the coordinational proximity of the chiral substrate and catalyst</a> in the key Aza-Michael/Michael cascade resulting in a substantial steric discrimination and an excellent overall diastereoselectivity. Whereas the “subcatalyst” (hidden catalyst) is not present in the reaction’s initial components, which renders a chiral catalyst-free process, it is strategically produced to promote sequential self-catalyzed reactions. The success of this methodology will pave the way for many efficient preparations of chiral complex molecules and aid for the quest to create next generation of therapeutic agents.</p>

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