Location of the gene specifying cytosine deaminase in Escherichia coli

S. I. Ahmad; R. H. Pritchard

doi:10.1007/bf00333567

Location of the gene specifying cytosine deaminase in Escherichia coli

MGG Molecular & General Genetics ◽

10.1007/bf00333567 ◽

1972 ◽

Vol 118 (4) ◽

pp. 323-325 ◽

Cited By ~ 1

Author(s):

S. I. Ahmad ◽

R. H. Pritchard

Keyword(s):

Escherichia Coli ◽

Cytosine Deaminase

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Mutation of Escherichia coli cytosine deaminase significantly enhances molecular chemotherapy of human glioma

Gene Therapy ◽

10.1038/sj.gt.3302965 ◽

2007 ◽

Vol 14 (14) ◽

pp. 1111-1119 ◽

Cited By ~ 19

Author(s):

S A Kaliberov ◽

J M Market ◽

G Y Gillespie ◽

V Krendelchtchikova ◽

D Della Manna ◽

...

Keyword(s):

Escherichia Coli ◽

Cytosine Deaminase ◽

Human Glioma ◽

Molecular Chemotherapy

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Rationally designed Escherichia coli cytosine deaminase mutants with improved specificity towards the prodrug 5-fluorocytosine for potential gene therapy applications

MedChemComm ◽

10.1039/c2md20209c ◽

2012 ◽

Vol 3 (10) ◽

pp. 1316 ◽

Cited By ~ 4

Author(s):

V. Kohila ◽

Amit Jaiswal ◽

Siddhartha Sankar Ghosh

Keyword(s):

Escherichia Coli ◽

Gene Therapy ◽

Cytosine Deaminase

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947. Gene Directed Enzyme/Prodrug Therapy of Human Glioma Xenografts Using Mutant Escherichia coli Cytosine Deaminase

Molecular Therapy ◽

10.1016/j.ymthe.2006.08.1038 ◽

2006 ◽

Vol 13 ◽

pp. S365-S366

Author(s):

Sergey A. Kaliberov ◽

Valentina Krendelchtchikova ◽

Debbie Della Manna ◽

Jeffrey C. Sellers ◽

Lyudmila N. Kaliberova ◽

...

Keyword(s):

Escherichia Coli ◽

Cytosine Deaminase ◽

Human Glioma ◽

Enzyme Prodrug Therapy

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A Novel Oncolytic Adenovirus Expressing Escherichia coli Cytosine Deaminase Exhibits Potent Antitumor Effect on Human Solid Tumors

Cancer Biotherapy & Radiopharmaceuticals ◽

10.1089/cbr.2009.0752 ◽

2010 ◽

Vol 25 (4) ◽

pp. 487-495 ◽

Cited By ~ 5

Author(s):

Jufeng Zhang ◽

Fang Wei ◽

Huiping Wang ◽

Huiming Li ◽

Wei Qiu ◽

...

Keyword(s):

Escherichia Coli ◽

Solid Tumors ◽

Antitumor Effect ◽

Cytosine Deaminase ◽

Oncolytic Adenovirus ◽

Human Solid Tumors

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Computational modeling and functional analysis of Herpes simplex virus type-1 thymidine kinase and Escherichia coli cytosine deaminase fusion protein

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2007.05.220 ◽

2007 ◽

Vol 360 (1) ◽

pp. 46-50 ◽

Cited By ~ 1

Author(s):

Jufeng Zhang ◽

Zhanli Wang ◽

Fang Wei ◽

Wei Qiu ◽

Liangren Zhang ◽

...

Keyword(s):

Escherichia Coli ◽

Functional Analysis ◽

Herpes Simplex Virus ◽

Herpes Simplex ◽

Fusion Protein ◽

Computational Modeling ◽

Herpes Simplex Virus Type ◽

Cytosine Deaminase ◽

Simplex Virus

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The structure of Escherichia coli cytosine deaminase 1 1Edited by I. A. Wilson

Journal of Molecular Biology ◽

10.1006/jmbi.2001.5277 ◽

2002 ◽

Vol 315 (4) ◽

pp. 687-697 ◽

Cited By ~ 80

Author(s):

Gregory C. Ireton ◽

Gerry McDermott ◽

Margaret E. Black ◽

Barry L. Stoddard

Keyword(s):

Escherichia Coli ◽

Cytosine Deaminase

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Escherichia coli cytosine deaminase: the kinetics and thermodynamics for binding of cytosine to the apoenzyme and the Zn2+ holoenzyme are similar

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ◽

10.1016/s0167-4838(99)00246-0 ◽

2000 ◽

Vol 1476 (2) ◽

pp. 239-252 ◽

Cited By ~ 12

Author(s):

David J.T. Porter

Keyword(s):

Escherichia Coli ◽

Cytosine Deaminase ◽

Kinetics And Thermodynamics

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Regional Delivery of an Adenovirus Vector Containing the Escherichia coli Cytosine Deaminase Gene to Provide Local Activation of 5-Fluorocytosine to Suppress the Growth of Colon Carcinoma Metastatic to Liver

Human Gene Therapy ◽

10.1089/hum.1996.7.13-1567 ◽

1996 ◽

Vol 7 (13) ◽

pp. 1567-1576 ◽

Cited By ~ 59

Author(s):

Akihiko Ohwada ◽

Edward A. Hirschowitz ◽

Ronald G. Crystal

Keyword(s):

Escherichia Coli ◽

Colon Carcinoma ◽

Cytosine Deaminase ◽

Adenovirus Vector ◽

Local Activation ◽

Regional Delivery ◽

Cytosine Deaminase Gene

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Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of Escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine

Cancer Gene Therapy ◽

10.1038/sj.cgt.7700189 ◽

2000 ◽

Vol 7 (7) ◽

pp. 1015-1022 ◽

Cited By ~ 24

Author(s):

Fumikazu Koyama ◽

Hidetomo Sawada ◽

Tomoko Hirao ◽

Hisao Fujii ◽

Hirofumi Hamada ◽

...

Keyword(s):

Escherichia Coli ◽

Colon Cancer ◽

Cytosine Deaminase ◽

Suicide Gene ◽

Human Colon ◽

Colon Cancer Cells ◽

Human Colon Cancer ◽

Uracil Phosphoribosyltransferase ◽

Human Colon Cancer Cells ◽

Cytosine Deaminase Gene

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Cytosine Deaminase as a Negative Selection Marker for Gene Disruption and Replacement in the Genus Streptomyces and Other Actinobacteria

Applied and Environmental Microbiology ◽

10.1128/aem.02139-08 ◽

2008 ◽

Vol 75 (4) ◽

pp. 1211-1214 ◽

Cited By ~ 32

Author(s):

Marie-Pierre Dubeau ◽

Mariana Gabriela Ghinet ◽

Pierre-ï¿½tienne Jacques ◽

Nancy Clermont ◽

Carole Beaulieu ◽

...

Keyword(s):

Escherichia Coli ◽

Gene Disruption ◽

Negative Selection ◽

Cytosine Deaminase ◽

Synthetic Gene ◽

Selection Marker ◽

Selection System ◽

Gene Encoding ◽

Genus Streptomyces ◽

Negative Selection Marker

ABSTRACT We developed a novel negative selection system for actinobacteria based on cytosine deaminase (CodA). We constructed vectors that include a synthetic gene encoding the CodA protein from Escherichia coli optimized for expression in Streptomyces species. Gene disruption and the introduction of an unmarked in-frame deletion were successfully achieved with these vectors.

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