054 Determination of clarithromycin and its R-14-hydroxy-metabolite in human serum and urine by reversed-phase HPLC and electrochemical detection

1992 ◽  
Vol 343 (1) ◽  
pp. 109-110 ◽  
Author(s):  
K. Borner ◽  
H. Hartwig ◽  
H. Lode
2004 ◽  
Vol 53 (7) ◽  
pp. 705-713
Author(s):  
Susumu ICHINOKI ◽  
Setsuko WATANABE ◽  
Saki MATSUIDA ◽  
Youichi FUJII ◽  
Toshihiro MORITA ◽  
...  

1986 ◽  
Vol 1 (2) ◽  
pp. 53-57 ◽  
Author(s):  
Wang Zeren ◽  
Lu Minglian ◽  
Xu Peipei ◽  
Zeng Yanlin ◽  
Zeng Yanlin

1999 ◽  
Vol 82 (2) ◽  
pp. 244-247 ◽  
Author(s):  
M H Guermouche ◽  
D Habel ◽  
S Guermouche

Abstract Determination of tinidazole in human serum by high-performance thin-layer chromatography (HPTLC) is presented. It includes use of 10 × 10 cm plates coated with silica gel 60 and chloroform-acetonitrile-acetic acid (60 + 40 + 2) as mobile phase. Quantitation was performed by densitometry at 320 nm. The linearity (1-10 ng), precision (6%), reproducibility (5%), recovery (96%), and detection limit (1 mg/L) of tinidazole determination by HPTLC were comparable with corresponding method parameters by reversed-phase HPLC. A satisfactory correlation was found between the 2 analytical methods. The procedure was used to quantitate tinidazole in patient sera.


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