027 Simplified chromatographic isolation of sex hormone-binding globulin from follicular fluid

1992 ◽  
Vol 343 (1) ◽  
pp. 79-80
Author(s):  
P. Luppa ◽  
I. Schwab ◽  
D. Neumeier ◽  
D. Seidel ◽  
T. Strowitzki
Keyword(s):  
Follicular Fluid ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Chromatographic Isolation

Serum and follicular fluid sex hormone-binding globulin in stimulated and unstimulated cycles

1995 ◽  
Vol 12 (6) ◽  
pp. 348-353 ◽  
Author(s):  
I. Phocas ◽  
TH. Mantzavinos ◽  
A. Sarandakou ◽  
F. Dimitriadou ◽  
P. A. Zourlas
Keyword(s):  
Follicular Fluid ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Sex-hormone-binding globulin in human follicular fluid and serum at the time of oocyte recovery

1989 ◽  
Vol 1 (4) ◽  
pp. 289 ◽  
Author(s):  
SM Campo ◽  
PA Rogers ◽  
JK Findlay
Keyword(s):  
Follicular Fluid ◽  
Binding Activity ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Human Follicular Fluid ◽  
Fertilization Program ◽  
Vitro Fertilization ◽  
Oocyte Recovery

Androgen binding activity, indistinguishable from sex-hormone-binding globulin (SHBG) in serum, has been identified in human follicular fluid by binding analyses (saturation and Scatchard analyses and binding specificity), immunoradiometric assay and Con-A Sepharose chromatography. Follicular fluid was obtained at the time of oocyte recovery from either individual follicles (range 2-7) from seven patients, or as a pool obtained from follicles of several patients who had received a Clomid-human menopausal gonadotrophin treatment to stimulate follicular growth as part of an in vitro fertilization program. Concentrations of SHBG in follicular fluid varied between individual follicles (750 +/- 202 fmol mg-1 protein; mean +/- s.d.; n = 14) and ranged above and below concentrations of SHBG in serum (948 +/- 171 fmol mg-1 protein; n = 5) taken 4 h before oocyte recovery and harvest of follicular fluid. There were strong correlations (r = 0.7-0.9) between the steroid and SHBG contents in individual follicular fluids of two patients. However, the concentration of SHBG in follicular fluid was generally 100-fold lower than that of oestradiol or progesterone, suggesting that SHBG may play some role other than determining the concentration of unbound steroid in the follicle.

Effects of oestradiol on sex hormone binding globulin

1982 ◽  
Vol 101 (2) ◽  
pp. 248-253 ◽  
Author(s):  
Viveca Odlind ◽  
Kerstin Elamsson ◽  
Doris E. Englund ◽  
Arne Victor ◽  
Elof D. B. Johansson
Keyword(s):  
Luteal Phase ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding ◽  
Pronounced Increase ◽  
Menstrual Cycles ◽  
Menopausal Women ◽  
Plasma Oestradiol

Abstract. Sex hormone binding globulin (SHBG) levels were studied for possible effects of oestradiol-17β on SHBG. No change in SHBG plasma was recorded during normal menstrual cycles or during treatment with oestradiol-17β to menopausal women. However, gonadotrophin treatment to amenorrhoeic women to induce ovulation resulted in high oestradiol concentrations and a pronounced increase in SHBG was found during the luteal phase of these cycles. A marked increase of SHBG was also recorded in a woman with pronounced fluctuations of oestradiol during treatment with levonorgestrel sc implants for contraception. In conclusion, effects on SHBG were only found when extraordinarily high levels of plasma oestradiol were recorded.

Sex hormone-binding globulin (SHBG) and androgen levels in women with androgenetic alopecia

1987 ◽  
Vol 116 (3_Suppl) ◽  
pp. S144 ◽  
Author(s):  
G. SINNECKER ◽  
E. LUDWIG ◽  
A. KRENZ ◽  
R.P. WILLIG
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Androgenetic Alopecia ◽  
Hormone Binding ◽  
Androgen Levels

Characterization of sex hormone binding globulin ligands with potential to enhance sex steroid action

2018 ◽  
Author(s):  
Phillip Round ◽  
Samir Das ◽  
Kristiina Wahala ◽  
Petegem Filip Van ◽  
Geoffrey Hammond
Keyword(s):  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Sex Steroid ◽  
Hormone Binding
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