Repair and mutation following UV damage in heterokaryons of Neurospora

David R. Stadler

doi:10.1007/bf00330644

Repair and mutation following UV damage in heterokaryons of Neurospora

MGG Molecular & General Genetics ◽

10.1007/bf00330644 ◽

1983 ◽

Vol 190 (2) ◽

pp. 227-232 ◽

Cited By ~ 9

Author(s):

David R. Stadler

Keyword(s):

Uv Damage

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Synthetic Melanin Tans Skin, Reduces Cellular UV Damage

Internal Medicine News ◽

10.1016/s1097-8690(06)73873-2 ◽

2006 ◽

Vol 39 (14) ◽

pp. 41

Author(s):

BETSY BATES

Keyword(s):

Uv Damage

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Faculty Opinions recommendation of Repair of UV damage in Halobacterium salinarum.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1010245.192568 ◽

2003 ◽

Author(s):

Shiladitya DasSarma

Keyword(s):

Halobacterium Salinarum ◽

Uv Damage

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Photoprotective Properties of Eumelanin: Computational Insights into the Photophysics of a Catechol:Quinone Heterodimer Model System

Photochem ◽

10.3390/photochem1010003 ◽

2021 ◽

Vol 1 (1) ◽

pp. 26-37

Author(s):

Victoria C. Frederick ◽

Thomas A. Ashy ◽

Barbara Marchetti ◽

Michael N. R. Ashfold ◽

Tolga N. V. Karsili

Keyword(s):

Ground State ◽

Sandwich Structure ◽

Computational Study ◽

Minimum Energy ◽

Carbonyl Oxygen ◽

Model System ◽

Molecular Structures ◽

Uv Damage ◽

Chromosomal Dna ◽

Relevant Model

Melanins are skin-centered molecular structures that block harmful UV radiation from the sun and help protect chromosomal DNA from UV damage. Understanding the photodynamics of the chromophores that make up eumelanin is therefore paramount. This manuscript presents a multi-reference computational study of the mechanisms responsible for the experimentally observed photostability of a melanin-relevant model heterodimer comprising a catechol (C)–benzoquinone (Q) pair. The present results validate a recently proposed photoinduced intermolecular transfer of an H atom from an OH moiety of C to a carbonyl-oxygen atom of the Q. Photoexcitation of the ground state C:Q heterodimer (which has a π-stacked “sandwich” structure) results in population of a locally excited ππ* state (on Q), which develops increasing charge-transfer (biradical) character as it evolves to a “hinged” minimum energy geometry and drives proton transfer (i.e., net H atom transfer) from C to Q. The study provides further insights into excited state decay mechanisms that could contribute to the photostability afforded by the bulk polymeric structure of eumelanin.

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