Branched-chain amino acids in the treatment of amyotrophic lateral sclerosis

1989 ◽  
Vol 236 (8) ◽  
pp. 445-447 ◽  
Author(s):  
D. Testa ◽  
T. Caraceni ◽  
V. Fetoni
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Branched Chain Amino Acids ◽  
Branched Chain ◽  
Lateral Sclerosis

Complex behavioral and synaptic effects of dietary branched chain amino acids in a mouse model of amyotrophic lateral sclerosis

2011 ◽  
Vol 55 (4) ◽  
pp. 541-552 ◽  
Author(s):  
Aldina Venerosi ◽  
Alberto Martire ◽  
Angela Rungi ◽  
Massimo Pieri ◽  
Antonella Ferrante ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Mouse Model ◽  
Branched Chain Amino Acids ◽  
Branched Chain ◽  
Synaptic Effects ◽  
Lateral Sclerosis

scholarly journals Prediagnostic plasma branched chain amino acids and the risk of amyotrophic lateral sclerosis

Neurology ◽  
2018 ◽  
pp. 10.1212/WNL.0000000000006669
Author(s):  
Kjetil Bjornevik ◽  
Éilis J. O'Reilly ◽  
James D. Berry ◽  
Clary B. Clish ◽  
Sarah Jeanfavre ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Branched Chain Amino Acids ◽  
Branched Chain ◽  
Lateral Sclerosis

Branched Chain Amino Acids in Experimental Models of Amyotrophic Lateral Sclerosis

2015 ◽  
pp. 229-241
Author(s):  
Alessia De Felice ◽  
Annamaria Confaloni ◽  
Alessio Crestini ◽  
Roberta De Simone ◽  
Fiorella Malchiodi-Albedi ◽  
...  
Keyword(s):  
Amino Acids ◽  
Amyotrophic Lateral Sclerosis ◽  
Branched Chain Amino Acids ◽  
Experimental Models ◽  
Branched Chain ◽  
Lateral Sclerosis

The Weight Loss Effects of Branched Chain Amino Acids and Vitamin B6: A Randomized Controlled Trial on Obese and Overweight Women

2018 ◽  
Vol 88 (1-2) ◽  
pp. 80-89 ◽  
Author(s):  
Zahra Shakibay Novin ◽  
Saeed Ghavamzadeh ◽  
Alireza Mehdizadeh
Keyword(s):  
Amino Acids ◽  
Weight Loss ◽  
Body Composition ◽  
Vitamin B6 ◽  
Controlled Trial ◽  
Density Lipoprotein ◽  
Branched Chain Amino Acids ◽  
Model Assessment ◽  
Waist To Hip Ratio ◽  
Branched Chain

Abstract. Branched chain amino acids (BCAA), with vitamin B6 have been reported to improve fat metabolism and muscle synthesis. We hypothesized that supplementation with BCAA and vitamin B6 would result in more weight loss and improve body composition and blood markers related to cardiovascular diseases. Our aim was to determine whether the mentioned supplementation would affect weight loss, body composition, and cardiovascular risk factors during weight loss intervention. To this end, we performed a placebo-controlled randomized clinical trial in 42 overweight and obese women (BMI = 25–34.9 kg/m2). Taking a four-week moderate deficit calorie diet (–500 kcal/day), participants were randomized to receive BCAA (6 g/day) with vitamin B6 (40 mg/day) or placebo. Body composition variables measured with the use of bioelectrical impedance analysis, homeostatic model assessment, and plasma insulin, Low density lipoprotein, High density lipoprotein, Total Cholesterol, Triglyceride, and fasting blood sugar were measured. The result indicated that, weight loss was not significantly affected by BCAA and vitamin B6 supplementation (–2.43 ± 1.02 kg) or placebo (–1.64 ± 1.48 kg). However, significant time × treatment interactions in waist to hip ratio (P = 0.005), left leg lean (P = 0.004) and right leg lean (P = 0.023) were observed. Overall, supplementation with BCAA and vitamin B6 could preserve legs lean and also attenuated waist to hip ratio.

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