Model of discharge patterns of units in the cochlear nucleus in response to steady state and time-varying sounds

1975 ◽  
Vol 20 (2) ◽  
pp. 113-119 ◽  
Author(s):  
Hans G. Nilsson
Keyword(s):  
Steady State ◽  
Cochlear Nucleus ◽  
Time Varying ◽  
Discharge Patterns

The representations of the steady-state vowel sound /e/ in the discharge patterns of cat anteroventral cochlear nucleus neurons

1990 ◽  
Vol 63 (5) ◽  
pp. 1191-1212 ◽  
Author(s):  
C. C. Blackburn ◽  
M. B. Sachs
Keyword(s):  
Steady State ◽  
Cochlear Nucleus ◽  
Nerve Fibers ◽  
Stimulus Level ◽  
Complex Stimulus ◽  
Vowel Sound ◽  
Stimulus Representation ◽  
Anteroventral Cochlear Nucleus ◽  
Discharge Patterns ◽  
Bushy Cells

1. We have recorded the responses of neurons in the anteroventral cochlear nucleus (AVCN) of barbiturate-anesthetized cats to the synthetic, steady-state-vowel sound /e/, presented over a range of stimulus intensities. 2. The responses of (putative) spherical bushy cells [primary-like (Pri) units] to the vowel resemble those of auditory-nerve fibers (ANFs) in terms of both rate and temporal encoding at low and moderate stimulus levels. It was not possible to study the responses of most Pri units at the highest stimulus level because of the large neurophonic component present in recordings from most primarylike units at higher stimulus levels. 3. The responses of many (putative) globular bushy cells [primarylike with notch (PN) units] to the vowel resemble those of ANFs; however, there appears to be greater heterogeneity in the responses of units in the PN population than in the Pri population in terms of both temporal and rate encoding. 4. Populations of stellate cells (chopper units) have degraded representations of the temporal information in ANF population discharge patterns in response to the vowel; this is consistent with the responses of these units to pure tones. Both regular (ChS) and irregular (ChT) chopper subpopulations, however, maintain better rate-place representations of the vowel spectrum than does the population of ANFs as a whole. The rate-place representations of the vowel spectrum by both chopper populations closely resemble those of low and medium spontaneous rate ANFs at most stimulus levels. 5. The data presented in this paper suggest that a functional partition of the AVCN chopper population could yield two distinct rate representations in response to a complex stimulus: one that is graded with stimulus level (over a 30 to 40 dB range) and that, even at rate saturation, maintains a "low contrast" stimulus representation; and a second that maintains a robust, "high contrast" stimulus representation at all levels but that confers less information about stimulus level.

The Roles Potassium Currents Play in Regulating the Electrical Activity of Ventral Cochlear Nucleus Neurons

2003 ◽  
Vol 89 (6) ◽  
pp. 3097-3113 ◽  
Author(s):  
Jason S. Rothman ◽  
Paul B. Manis
Keyword(s):  
Cochlear Nucleus ◽  
Auditory Nerve ◽  
Threshold Current ◽  
Repetitive Firing ◽  
Resting Membrane Potential ◽  
Type I ◽  
Type Ii Cells ◽  
Type Ii ◽  
Ventral Cochlear Nucleus ◽  
Discharge Patterns

Using kinetic data from three different K+ currents in acutely isolated neurons, a single electrical compartment representing the soma of a ventral cochlear nucleus (VCN) neuron was created. The K+ currents include a fast transient current ( IA), a slow-inactivating low-threshold current ( ILT), and a noninactivating high-threshold current ( IHT). The model also includes a fast-inactivating Na+ current, a hyperpolarization-activated cation current ( Ih), and 1–50 auditory nerve synapses. With this model, the role IA, ILT, and IHT play in shaping the discharge patterns of VCN cells is explored. Simulation results indicate that IHT mainly functions to repolarize the membrane during an action potential, and IA functions to modulate the rate of repetitive firing. ILT is found to be responsible for the phasic discharge pattern observed in Type II cells (bushy cells). However, by adjusting the strength of ILT, both phasic and regular discharge patterns are observed, demonstrating that a critical level of ILT is necessary to produce the Type II response. Simulated Type II cells have a significantly faster membrane time constant in comparison to Type I cells (stellate cells) and are therefore better suited to preserve temporal information in their auditory nerve inputs by acting as precise coincidence detectors and having a short refractory period. Finally, we demonstrate that modulation of Ih, which changes the resting membrane potential, is a more effective means of modulating the activation level of ILT than simply modulating ILT itself. This result may explain why ILT and Ih are often coexpressed throughout the nervous system.

Modelling the sensitivity of cells in the anteroventral cochlear nucleus to spatiotemporal discharge patterns

1992 ◽  
Vol 336 (1278) ◽  
pp. 403-406 ◽  
Keyword(s):  
Cochlear Nucleus ◽  
Auditory Nerve ◽  
Cross Correlation ◽  
Low Frequency ◽  
Phase Spectrum ◽  
Coincidence Detection ◽  
Potential Mechanism ◽  
Complex Sounds ◽  
Anteroventral Cochlear Nucleus ◽  
Discharge Patterns

This study investigates a potential mechanism for the processing of acoustic information that is encoded in the spatiotemporal discharge patterns of auditory nerve (AN) fibres. Recent physiological evidence has demonstrated that some low-frequency cells in the anteroventral cochlear nucleus (AVCN) are sensitive to manipulations of the phase spectrum of complex sounds (Carney 1990 b ). These manipulations result in systematic changes in the spatiotemporal discharge patterns across groups of low-frequency an fibres having different characteristic frequencies (CFS). One interpretation of these results is that these neurons in the AVCN receive convergent inputs from AN fibres with different CFS, and that the cells perform a coincidence detection or cross-correlation upon their inputs. This report presents a model that was developed to test this interpretation.

On Stability of a Nonlinear, Periodically Time Varying, Rotating Blade

2011 ◽  
Author(s):  
Fengxia Wang
Keyword(s):  
Steady State ◽  
Differential Equations ◽  
Nonlinear Partial Differential Equations ◽  
Multiple Time ◽  
Time Varying ◽  
Rotating Blade ◽  
Stability And Bifurcation ◽  
Geometric Stiffening ◽  
Rotational Motions ◽  
The Stability

This paper discusses the stability of a periodically time-varying, spinning blade with cubic geometric nonlinearity. The modal reduction method is adopted to simplify the nonlinear partial differential equations to the ordinary differential equations, and the geometric stiffening is approximated by the axial inertia membrane force. The method of multiple time scale is employed to study the steady state motions, the corresponding stability and bifurcation for such a periodically time-varying rotating blade. The backbone curves for steady-state motions are achieved, and the parameter map for stability and bifurcation is developed. Illustration of the steady-state motions is presented for an understanding of rotational motions of the rotating blade.

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