Solid-state NMR as an analytical technique offering spatially resolved chemical information

1994 ◽  
Vol 349 (1-3) ◽  
pp. 112-116 ◽  
Author(s):  
G. Neue ◽  
U. Skibbe ◽  
C. Dybowski
Keyword(s):  
Solid State ◽  
Solid State Nmr ◽  
Chemical Information ◽  
Analytical Technique ◽  
Spatially Resolved

scholarly journals A novel multinuclear solid-state NMR approach for the characterization of kidney stones

2021 ◽  
Vol 2 (2) ◽  
pp. 653-671
Author(s):  
César Leroy ◽  
Laure Bonhomme-Coury ◽  
Christel Gervais ◽  
Frederik Tielens ◽  
Florence Babonneau ◽  
...  
Keyword(s):  
Solid State ◽  
Kidney Stones ◽  
Solid State Nmr ◽  
Magic Angle Spinning ◽  
Mas Nmr ◽  
Magic Angle ◽  
Nmr Studies ◽  
Stone Composition ◽  
Analytical Technique ◽  
Nmr Data

Abstract. The spectroscopic study of pathological calcifications (including kidney stones) is extremely rich and helps to improve the understanding of the physical and chemical processes associated with their formation. While Fourier transform infrared (FTIR) imaging and optical/electron microscopies are routine techniques in hospitals, there has been a dearth of solid-state NMR studies introduced into this area of medical research, probably due to the scarcity of this analytical technique in hospital facilities. This work introduces effective multinuclear and multidimensional solid-state NMR methodologies to study the complex chemical and structural properties characterizing kidney stone composition. As a basis for comparison, three hydrates (n=1, 2 and 3) of calcium oxalate are examined along with nine representative kidney stones. The multinuclear magic angle spinning (MAS) NMR approach adopted investigates the 1H, 13C, 31P and 31P nuclei, with the 1H and 13C MAS NMR data able to be readily deconvoluted into the constituent elements associated with the different oxalates and organics present. For the first time, the full interpretation of highly resolved 1H NMR spectra is presented for the three hydrates, based on the structure and local dynamics. The corresponding 31P MAS NMR data indicates the presence of low-level inorganic phosphate species; however, the complexity of these data make the precise identification of the phases difficult to assign. This work provides physicians, urologists and nephrologists with additional avenues of spectroscopic investigation to interrogate this complex medical dilemma that requires real, multitechnique approaches to generate effective outcomes.

scholarly journals Hierarchical Structure and Molecular Dynamics of Metal-Organic Framework as Characterized by Solid State NMR

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Wei Chen ◽  
Yi-nan Wu ◽  
Fengting Li
Keyword(s):  
Molecular Dynamics ◽  
Solid State ◽  
Solid State Nmr ◽  
Metal Organic Framework ◽  
Level Structure ◽  
Structure Information ◽  
Analytical Technique ◽  
Metal Organic ◽  
Indispensable Tool ◽  
Organic Framework

Metal-organic framework (MOF) stands out as a promising material with great potential in application areas, such as gas separation and catalysis, due to its extraordinary properties. In order to fully characterize the structure of MOFs, especially those without single crystal, Solid State NMR (SSNMR) is an indispensable tool. As a complimentary analytical technique to X-ray diffraction, SSNMR could provide detailed atomic level structure information. Meanwhile, SSNMR can characterize molecular dynamics over a wide dynamics range. In this review, selected applications of SSNMR on various MOFs are summarized and discussed.

Spatially Resolved Two-Dimensional Solid-State NMR Spectroscopy

1994 ◽  
Vol 107 (2) ◽  
pp. 251-254 ◽  
Author(s):  
U. Scheler ◽  
J.J. Titman ◽  
B. Blumich ◽  
H.W. Spiess
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Solid State Nmr ◽  
Two Dimensional ◽  
Solid State Nmr Spectroscopy ◽  
Spatially Resolved

scholarly journals Light in Electrochemistry

Electrochem ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 472-489
Author(s):  
Hiroya Abe ◽  
Tomoki Iwama ◽  
Yuanyuan Guo
Keyword(s):  
Food Security ◽  
Health Monitoring ◽  
Effective Means ◽  
Cost Effective ◽  
Semiconductor Materials ◽  
Chemical Information ◽  
Security Screening ◽  
Analytical Technique ◽  
Spatially Resolved ◽  
Biological Studies

Electrochemistry represents an important analytical technique used to acquire and assess chemical information in detail, which can aid fundamental investigations in various fields, such as biological studies. For example, electrochemistry can be used as simple and cost-effective means for bio-marker tracing in applications, such as health monitoring and food security screening. In combination with light, powerful spatially-resolved applications in both the investigation and manipulation of biochemical reactions begin to unfold. In this article, we focus primarily on light-addressable electrochemistry based on semiconductor materials and light-readable electrochemistry enabled by electrochemiluminescence (ECL). In addition, the emergence of multiplexed and imaging applications will also be introduced.

scholarly journals A novel multinuclear solid state NMR approach for the characterization of kidney stones

2021 ◽  
Author(s):  
César Leroy ◽  
Laure Bonhomme-Coury ◽  
Christel Gervais ◽  
Frederik Tielens ◽  
Florence Babonneau ◽  
...  
Keyword(s):  
Solid State ◽  
Kidney Stones ◽  
Solid State Nmr ◽  
Mas Nmr ◽  
Nmr Studies ◽  
Stone Composition ◽  
Analytical Technique ◽  
Electron Microscopies ◽  
Nmr Data ◽  
Optical Electron

Abstract. The spectroscopic study of pathological calcifications (including kidney stones) is extremely rich and helps to improve the understanding of the physical and chemical processes associated with their formation. While FTIR imaging and optical/electron microscopies are routine techniques in hospitals, there has been a dearth of solid state NMR studies introduced into this area of medical research, probably due to the scarcity of this analytical technique in hospital facilities. This work introduces effective multinuclear and multi-dimensional solid state NMR methodologies to study the complex chemical and structural properties characterising kidney stone composition. As a basis for comparison three hydrates (n = 1, 2 and 3) of calcium oxalate are examined along with nine representative kidney stones. The multinuclear MAS NMR approach adopted investigates the 1H, 13C, 31P and 43Ca nuclei, with the 1H and 13C MAS NMR data able to be readily deconvoluted into the constituent elements associated with the different oxalates and organics present. For the first time, the full interpretation of highly resolved 1H NMR spectra is presented for the three hydrates, based on structure and local dynamics. The corresponding 31P MAS NMR data indicates the presence of low-level inorganic phosphate species, however the complexity of these data make the precise identification of the phases difficult to assign. This work provides physicians, urologists and nephrologists with additional avenues of spectroscopic investigation to interrogate this complex medical dilemma that requires real multi technique approaches to generate effective outcomes.

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