The perineuronal net in the fastigial nucleus of the rat cerebellum

1984 ◽  
Vol 170 (1) ◽  
pp. 79-85 ◽  
Author(s):  
M. Lafarga ◽  
M. T. Berciano ◽  
M. Blanco
1992 ◽  
Vol 23 (4) ◽  
pp. 323-330
Author(s):  
A. S. Amatuni ◽  
R.Sh Sarkisyan ◽  
E. A. Korkotyan ◽  
A. K. Melikyan

2004 ◽  
Vol 26 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Bambang WISPRIYONO ◽  
Masato MATSUOKA ◽  
Hideki IGISU

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Johanna Habermeyer ◽  
Janina Boyken ◽  
Julia Harrer ◽  
Fabio Canneva ◽  
Veronika Ratz ◽  
...  

AbstractGadolinium based contrast agents (GBCAs) are widely used in clinical MRI since the mid-1980s. Recently, concerns have been raised that trace amounts of Gadolinium (Gd), detected in brains even long time after GBCA application, may cause yet unrecognized clinical consequences. We therefore assessed the behavioral phenotype, neuro-histopathology, and Gd localization after repeated administration of linear (gadodiamide) or macrocyclic (gadobutrol) GBCA in rats. While most behavioral tests revealed no difference between treatment groups, we observed a transient and reversible decrease of the startle reflex after gadodiamide application. Residual Gd in the lateral cerebellar nucleus was neither associated with a general gene expression pathway deregulation nor with neuronal cell loss, but in gadodiamide-treated rats Gd was associated with the perineuronal net protein aggrecan and segregated to high molecular weight fractions. Our behavioral finding together with Gd distribution and speciation support a substance class difference for Gd presence in the brain after GBCA application.


2019 ◽  
Vol 26 (21) ◽  
pp. 22061-22068
Author(s):  
Nahed A. Omar ◽  
Ali H. Abu-Almaaty ◽  
Yasmin M. Abd El-Aziz ◽  
Ahmed M. Abdeen ◽  
Fatma El Zahraa Ammar Mohamed ◽  
...  

2020 ◽  
Vol 295 (4) ◽  
pp. 955-968
Author(s):  
Geoffrey J. Eill ◽  
Ashis Sinha ◽  
Markus Morawski ◽  
Mariano S. Viapiano ◽  
Russell T. Matthews

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