Identification of skeletal muscle precursor cells in vivo by use of MyoD1 and myogenin probes

1992 ◽  
Vol 267 (1) ◽  
pp. 99-104 ◽  
Author(s):  
Miranda D. Grounds ◽  
Kerryn L. Garrett ◽  
May C. Lai ◽  
Woodring E. Wright ◽  
Manfred W. Beilharz
Keyword(s):  
Skeletal Muscle ◽  
Precursor Cells ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

Human muscle precursor cells give rise to functional satellite cells in vivo

2007 ◽  
Vol 17 (8) ◽  
pp. 631-638 ◽  
Author(s):  
Janine Ehrhardt ◽  
Karima Brimah ◽  
Carl Adkin ◽  
Terence Partridge ◽  
Jennifer Morgan
Keyword(s):  
Satellite Cells ◽  
Precursor Cells ◽  
Human Muscle ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

Analysis of the callipyge phenotype through skeletal muscle development; association of Dlk1 with muscle precursor cells

2008 ◽  
Vol 76 (3) ◽  
pp. 283-298 ◽  
Author(s):  
Jason D. White ◽  
Tony Vuocolo ◽  
Matthew McDonagh ◽  
Miranda D. Grounds ◽  
Gregory S. Harper ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Development ◽  
Precursor Cells ◽  
Skeletal Muscle Development ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

scholarly journals Sonic Hedgehog induces proliferation of committed skeletal muscle cells in the chick limb

Development ◽  
1998 ◽  
Vol 125 (3) ◽  
pp. 495-505 ◽  
Author(s):  
D. Duprez ◽  
C. Fournier-Thibault ◽  
N. Le Douarin
Keyword(s):  
Sonic Hedgehog ◽  
Primary Cultures ◽  
Posterior Part ◽  
Precursor Cells ◽  
Limb Bud ◽  
Lateral Part ◽  
Expression Domain ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

Myogenic Regulatory Factors (MRFs) are a family of transcription factors whose expression in a cell reflects the commitment of this cell to a myogenic fate before any cytological sign of muscle differentiation is detectable. Myogenic cells in limb skeletal muscles originate from the lateral half of the somites. Cells that migrate away from the lateral part of the somites to the limb bud do not initially express any member of the MRF family. Expression of MRFs in the muscle precursor cells starts after the migration process is completed. The extracellular signals involved in activating the myogenic programme in muscle precursor cells in the limb in vivo are not known. We wished to investigate whether Sonic Hedgehog (SHH) expressed in the posterior part of the limb bud could be involved in differentiation of the muscle precursor cells in the limb. We found that retrovirally overexpressed SHH in the limb bud induced the extension of the expression domain of the Pax-3 gene, then that of the MyoD gene and finally that of the myosin protein. This led to an hypertrophy of the muscles in vivo. Addition of SHH to primary cultures of myoblasts resulted in an increase in the proportion of myoblasts that incorporate bromodeoxyuridine, resulting in an increase of myotube number. These data show that SHH is able to activate myogenesis in vivo and in vitro in already committed myoblasts and suggest that the stimulation of the myogenic programme by SHH involves activation of cell proliferation.

scholarly journals N-cadherin Promotes the Commitment and Differentiation of Skeletal Muscle Precursor Cells

1997 ◽  
Vol 185 (1) ◽  
pp. 14-24 ◽  
Author(s):  
Mindy George-Weinstein ◽  
Jacquelyn Gerhart ◽  
Jennifer Blitz ◽  
Eileen Simak ◽  
Karen A. Knudsen
Keyword(s):  
Skeletal Muscle ◽  
Precursor Cells ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

Deficient leukemia inhibitory factor signaling in muscle precursor cells from patients with type 2 diabetes

2012 ◽  
Vol 303 (2) ◽  
pp. E283-E292 ◽  
Author(s):  
Christa Broholm ◽  
Claus Brandt ◽  
Ninna S. Schultz ◽  
Anders R. Nielsen ◽  
Bente K. Pedersen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Cell Proliferation ◽  
Leukemia Inhibitory Factor ◽  
Precursor Cells ◽  
Diabetic Patients ◽  
Healthy Individuals ◽  
Muscle Precursor ◽  
Muscle Precursor Cells

The cytokine leukemia-inhibitory factor (LIF) is expressed by skeletal muscle and induces proliferation of muscle precursor cells, an important feature of skeletal muscle maintenance and repair. We hypothesized that muscle precursor cells from patients with type 2 diabetes had a deficient response to LIF. The mRNA and protein expressions of LIF and its receptor (LIFR) were measured in skeletal muscle biopsies from healthy individuals and patients with type 2 diabetes by use of qPCR and Western blot. LIF signaling and response were studied following administration of recombinant LIF and siRNA knockdown of suppressor of cytokine signaling (SOCS)3 in myoblast cultures established from healthy individuals and patients with type 2 diabetes. Myoblast proliferation rate was assessed by bromodeoxyuridine incorporation. LIF and LIFR proteins were increased in both muscle tissue and cultured myoblasts from diabetic patients. Nonetheless, in the diabetic myoblasts, LIF-induced phosphorylation of signal transducer and activator of transcription (STAT)1 and STAT3 was impaired. The deficient response to LIF administration in the diabetic myoblasts was further emphasized by a lack of increase in LIF-stimulated cell proliferation and a decreased LIF-stimulated induction of the proliferation-promoting factors cyclin D1, JunB, and c-myc. SOCS3 protein was upregulated in diabetic myoblasts, and knockdown of SOCS3 rescued LIF-induced gene expression in diabetic myoblasts, whereas neither STAT1 or STAT3 signaling nor proliferation rate was affected. In conclusion, although LIF and LIFR proteins were increased in muscle tissue and myoblasts from diabetic patients, LIF signaling and LIF-stimulated cell proliferation were impaired in diabetic myoblasts, suggesting a novel mechanism by which muscle function is compromised in diabetes.

scholarly journals MR Imaging Relaxometry Allows Noninvasive Characterization of in Vivo Differentiation of Muscle Precursor Cells

Radiology ◽  
2015 ◽  
Vol 274 (3) ◽  
pp. 800-809 ◽  
Author(s):  
Natalie C. Chuck ◽  
Fahd Azzabi Zouraq ◽  
Markus Rottmar ◽  
Daniel Eberli ◽  
Andreas Boss
Keyword(s):  
Mr Imaging ◽  
Precursor Cells ◽  
Muscle Precursor ◽  
Noninvasive Characterization ◽  
In Vivo Differentiation ◽  
Muscle Precursor Cells
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