Nephrotoxic effect of Atractyloside in rats

1974 ◽  
Vol 32 (3) ◽  
pp. 169-180 ◽  
Author(s):  
F. Carpenedo ◽  
S. Luciani ◽  
F. Scaravilli ◽  
P. Palatini ◽  
R. Santi
Keyword(s):  
Nephrotoxic Effect

Nephrotoxic effect of Tris(2,3-dibromopropyl) phosphate on rat urinary metabolites: Assessment from13C-NMR spectra of urines and biochemical and histopathological examinations

1987 ◽  
Vol 7 (1) ◽  
pp. 23-34 ◽  
Author(s):  
Masamichi Fukuoka ◽  
Terue Takahashi ◽  
Akira Tanaka ◽  
Tsutomu Yamaha ◽  
Katushi Naito ◽  
...  
Keyword(s):  
Nmr Spectra ◽  
Urinary Metabolites ◽  
Nephrotoxic Effect

Nicorandil prevents the nephrotoxic effect of cyclosporine-A in albino rats through modulation of HIF-1α/VEGF /eNOS signaling

2020 ◽  
Author(s):  
Inas Harb ◽  
Hend Ashour ◽  
Dina Sabry ◽  
Dina Fawzy El-Yasergy ◽  
Wael Mostafa Hamza ◽  
...  
Keyword(s):  
Growth Factor ◽  
Endothelial Dysfunction ◽  
Cyclosporine A ◽  
Transforming Growth Factor ◽  
Hypoxia Inducible Factor ◽  
Chronic Administration ◽  
Immunosuppressive Drug ◽  
Vehicle Group ◽  
Albino Rats ◽  
Nephrotoxic Effect

Despite cyclosporine-A (CsA) is a widely used immunosuppressive drug; its nephrotoxic effect puts a limitation for chronic administration. Herein we tried to investigate its renal effect on endothelial dysfunction targeting the hypoxia-inducible factor (HIF-1α)/vascular endothelial growth factor (VEGF)/endothelial nitric oxide synthase (eNOS) pathway and the possible modulation by nicorandil. Eight groups of adult male Wistar rats were included; 1: control, 2: vehicle group (received oil), 3: glibebclamide 5mg/kg/day/orally was administered. 4: group received nicorandil 10mg/kg/day/orally. 5: group received cyclosporine 25mg/kg/day/orally. 6: combined cyclosporine and nicorandil, 7: glibenclamide was added to cyclosporine, and 8: group received both cyclosporine and nicorandil combined with glibenclamid. The treatment continued for 6 weeks. Combined nicorandil with cyclosporine improved renal function deterioration initiated by cyclosporine. Cyclosporine decreased the renal expression levels (P<0.001) of HIF-1α, eNOS, and VEGF inducing endothelial dysfunction and the triggered inflammation, and upregulated the pro-fibrotic marker transforming growth factor (TGF-β). Nicorandil fixed the disturbed HIF-1α/VEGF/eNOS signaling. Nicorandil corrected the renal functions confirmed by improved the histological glomerular tuft retraction that was obvious in the cyclosporine group, without significant influence by glibenclamid. Proper protection from CsA-induced nephrotoxicity was achieved by nicorandil. Nicorandil reversed the disturbed HIF-1α/VEGF/eNOS pathway created by cyclosporine.

Superoxide radical and nephrotoxic effect of cadmium exposure

1999 ◽  
Vol 9 (2) ◽  
pp. 109-116 ◽  
Author(s):  
Ethel L.B. Novelli ◽  
Ana M. Lopes ◽  
Ana S. Rodrigues ◽  
Jose L.V.B. Novelli Filho ◽  
Bartolome O. Ribas
Keyword(s):  
Superoxide Radical ◽  
Cadmium Exposure ◽  
Nephrotoxic Effect

Nephrotoxic effect of trimethyltin in rats

1985 ◽  
Vol 27 (1-3) ◽  
pp. 97-102 ◽  
Author(s):  
J. Opacka ◽  
S. Sparrow
Keyword(s):  
Nephrotoxic Effect

scholarly journals Evaluation of nephrotoxic effect of lead exposure among automobile repairers in Nnewi Metropolis

2014 ◽  
Vol 2 (3) ◽  
pp. 1107 ◽  
Author(s):  
Ubuo Amah ◽  
Nnamdi Madu ◽  
Joseph Ahaneku ◽  
Gladys Ahaneku ◽  
Christian Onah ◽  
...  
Keyword(s):  
Lead Exposure ◽  
Nephrotoxic Effect

scholarly journals Nephrotoxic Effect of Gentamicin and Amikacin in Neonates with Infection

2018 ◽  
Vol 10 (2) ◽  
Author(s):  
Saeed Alinejad ◽  
Parsa Yousefichaijan ◽  
Masoud Rezagholizamenjany ◽  
Yosef Rafie ◽  
Manijeh Kahbazi ◽  
...  
Keyword(s):  
Nephrotoxic Effect
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