Ultrastructural studies of the myenteric plexus and smooth muscle in organotypic cultures of the guinea-pig small intestine

1995 ◽  
Vol 280 (3) ◽  
pp. 627-637 ◽  
Author(s):  
Z.-M. Song ◽  
S. J. H. Brookes ◽  
I. J. Llewellyn-Smith ◽  
M. Costa
Keyword(s):  
Smooth Muscle ◽  
Small Intestine ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Organotypic Cultures ◽  
Ultrastructural Studies

The development and reversal of the tolerance to morphine in the longitudinal smooth muscle-myenteric plexus preparation of the guinea pig

Life Sciences ◽  
1989 ◽  
Vol 45 (16) ◽  
pp. 1483-1489 ◽  
Author(s):  
Judith A. Leedham ◽  
Nancy Doak ◽  
David A. Taylor ◽  
William W. Fleming
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Myenteric Plexus ◽  
Longitudinal Smooth Muscle

Distribution and function of enteric GAL-IR nerves in dogs: comparison with VIP

1989 ◽  
Vol 256 (5) ◽  
pp. G884-G896 ◽  
Author(s):  
T. Gonda ◽  
E. E. Daniel ◽  
T. J. McDonald ◽  
J. E. Fox ◽  
B. D. Brooks ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Small Intestine ◽  
Gastrointestinal Tract ◽  
Vasoactive Intestinal Polypeptide ◽  
Myenteric Plexus ◽  
Low Doses ◽  
Field Stimulation ◽  
And Function ◽  
Higher Doses ◽  
Stimulation Of

The distribution of nerves containing galanin-immunoreactive (GAL-IR) material was compared to the distribution of neurons containing vasoactive intestinal polypeptide (VIP) immunoreactivity in the canine gastrointestinal tract. The actions of intra-arterially administered galanin and VIP on motility in the gastric antrum and corpus and the intestines were also studied. All sphincter muscles contained galanin- and VIP-immunoreactive nerve profiles. VIP-immunoreactive nerve profiles were present in all layers of the stomach, small intestine, and colon. GAL-IR nerve somata were common in the submucous plexus of ileum and colon and in the myenteric plexus of the terminal antrum, as were nerve processes in various layers. In the small intestine, galanin inhibited contractile responses to field stimulation of intrinsic nerves and also reduced the contractions after nerve blockade with tetrodotoxin (TTX). VIP often enhanced field-stimulated contractions at low doses but inhibited these and the contractions after TTX at higher doses. In the stomach and colon, both peptides inhibited responses to field stimulation; whether these effects were due to actions on smooth muscle was not tested. The distribution and actions of galanin in gut are consistent with the hypothesis that it acts at smooth muscle sites and possibly at prejunctional sites.

Structure of the tertiary component of the myenteric plexus in the guinea-pig small intestine

1993 ◽  
Vol 272 (3) ◽  
pp. 509-516 ◽  
Author(s):  
I. J. Llewellyn-Smith ◽  
M. Costa ◽  
J. B. Furness ◽  
J. C. Bornstein
Keyword(s):  
Small Intestine ◽  
Guinea Pig ◽  
Myenteric Plexus
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