Growth hormone administration potentiates the effect of treadmill exercise on long bone formation but not on the vertebrae in middle-aged rats

1994 ◽  
Vol 54 (1) ◽  
pp. 38-43 ◽  
Author(s):  
J. K. Yeh ◽  
J. F. Aloia ◽  
M. Chen
Keyword(s):  
Growth Hormone ◽  
Bone Formation ◽  
Treadmill Exercise ◽  
Long Bone ◽  
Aged Rats ◽  
Middle Aged ◽  
Growth Hormone Administration ◽  
Hormone Administration

Effect of growth hormone administration and treadmill exercise on serum and skeletal IGF-I in rats

1994 ◽  
Vol 266 (1) ◽  
pp. E129-E135 ◽  
Author(s):  
J. K. Yeh ◽  
J. F. Aloia ◽  
M. Chen ◽  
N. Ling ◽  
H. C. Koo ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factors ◽  
Bone Formation ◽  
Treadmill Exercise ◽  
Formation Rate ◽  
Serum Levels ◽  
Long Bone ◽  
Bone Formation Rate ◽  
Hormone Administration ◽  
Igf I

Growth factors may be mediators of local and systemic factors that enhance bone formation. This study examined the effect of treadmill exercise and ovine growth hormone administration on levels of insulin-like growth factor I (IGF-I) in serum (ng/ml), long bone, and vertebrae and on bone formation rate. Forty female rats were divided into four groups: control; exercise (17 m/min, 1 h/day); growth hormone (0.05 mg.100 g-1.day-1); growth hormone plus exercise. After 9 wk of study, the serum levels of IGF-I were higher in the intervention groups than in the control group; however, the IGF-I concentration and the periosteal bone formation rate in the long bone were significantly higher only in the exercised rats. The IGF-I concentration and the cancellous bone formation rate in the vertebrae did not differ among the experimental groups. The vertebral and long bone formation rate were correlated with bone concentrations of IGF-I. Serum levels of IGF-I were also correlated with serum osteocalcin and the long bone formation but not with the vertebral bone formation. The association of bone formation with serum and bone IGF-I supports the suggestion that IGF-I is one of the growth factors that regulate bone formation, in particular as a mediator of the response of bone to exercise.

Effect of growth hormone administration and treadmill exercise on the body composition of rats

1994 ◽  
Vol 77 (1) ◽  
pp. 23-29 ◽  
Author(s):  
J. K. Yeh ◽  
J. F. Aloia ◽  
M. Chen ◽  
S. Sprintz
Keyword(s):  
Growth Hormone ◽  
Bone Mass ◽  
Body Fat ◽  
Fat Mass ◽  
Treadmill Exercise ◽  
The Body ◽  
Fat Free Mass ◽  
Body Fat Mass ◽  
Growth Hormone Administration ◽  
Hormone Administration

The aim of this study was to compare the effects of growth hormone administration and treadmill exercise on bone mass, body fat mass, and fat-free mass. Forty female rats aged 14 mo were divided into control, ovine growth hormone administration (0.5 mg.kg-1.day-1; GH), treadmill exercise (17 m/min, 60 min/day; EX), and EX + GH groups. Noninvasive total body electrical conductivity and dual X-ray absorptiometry techniques were used to assess the body fat content, fat-free mass, and tibial and L4 vertebral bone mineral content of each experimental animal at weeks 0, 9, and 16. The age-related increase in body fat mass was suppressed in the GH group, and the fat-free mass and L4 bone mass were higher in the GH group than in the control group. Conversely, in the EX group there was no gain in body fat mass and no significant change in fat-free mass or vertebral bone mass. The tibial bone mass increased in both the GH and EX groups; however, the time response to the two interventions appeared to differ. In the EX + GH group there was no further enhancement of the anabolic effect on the tibial bone mass. The effect of growth hormone administration on body fat content and bone mass is distinct from that of treadmill exercise.

scholarly journals Pharmacokinetics and Metabolic Effects of High-Dose Growth Hormone Administration in Healthy Adult Men.

1999 ◽  
Vol 46 (4) ◽  
pp. 605-612 ◽  
Author(s):  
TOSHIAKI TANAKA ◽  
YOSHIKI SEINO ◽  
KENJI FUJIEDA ◽  
YUTAKA IGARASHI ◽  
SUSUMU YOKOYA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Healthy Adult ◽  
Metabolic Effects ◽  
High Dose ◽  
Growth Hormone Administration ◽  
Adult Men ◽  
Hormone Administration

scholarly journals Effects of Growth Hormone Administration on Wool Growth in Merino Sheep

1988 ◽  
Vol 41 (2) ◽  
pp. 177 ◽  
Author(s):  
PC Wynn ◽  
ALC Wallace ◽  
AC Kirby ◽  
EF Annison
Keyword(s):  
Amino Acids ◽  
Growth Hormone ◽  
Energy Intake ◽  
Nitrogen Balance ◽  
Daily Administration ◽  
Maintenance Energy ◽  
Merino Sheep ◽  
Growth Hormone Administration ◽  
Hormone Administration ◽  
Wool Growth

The effects of daily administration of 10 mg of highly purified ovine growth hormone (GH) for a period of 4 weeks on wool growth have been measured in 12 Merino ewes fed either a calculated maintenance energy intake or 1�6 times this amount (six on each ration). Concentrations of hormones, glucose, urea, a-amino N and amino acids in the blood were monitored and faeces and urine collected for measurement of nitrogen balance.

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