Beta-adrenoceptor blockade potentiates exercise-induced release of atrial natriuretic peptide

1990 ◽  
Vol 38 (4) ◽  
pp. 363-366 ◽  
Author(s):  
G. Deray ◽  
I. Berlin ◽  
G. Maistre ◽  
F. Martinez ◽  
S. Legrand ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Beta Adrenoceptor ◽  
Exercise Induced ◽  
Atrial Natriuretic

Atrial natriuretic peptide and exercise-induced fluid retention in man

1991 ◽  
Vol 2 (2) ◽  
pp. 94-101 ◽  
Author(s):  
J.S. Milledge ◽  
S. McArthur ◽  
A. Morice ◽  
N. Luff ◽  
R. Abrahams ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Fluid Retention ◽  
Exercise Induced ◽  
Atrial Natriuretic

Tertatolol Potentiates Exercise-Induced Atrial Natriuretic Peptide Release by Increasing Atrial Diameter in Healthy Subjects

Cardiology ◽  
1993 ◽  
Vol 83 (1) ◽  
pp. 16-24 ◽  
Author(s):  
I. Berlin ◽  
G. Deray ◽  
P. Lechat ◽  
G. Maistre ◽  
C. Landault ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Healthy Subjects ◽  
Peptide Release ◽  
Exercise Induced ◽  
Atrial Natriuretic

Dynamic exercise-induced elevation in plasma levels of atrial natriuretic peptide in patients with effort angina pectoris

1990 ◽  
Vol 120 (6) ◽  
pp. 1298-1305 ◽  
Author(s):  
Tatsuyuki Matsunami ◽  
Mitsuhiro Yokota ◽  
Mitsunori Iwase ◽  
Makoto Watanabe ◽  
Takashi Miyahara ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Plasma Levels ◽  
Dynamic Exercise ◽  
Effort Angina ◽  
Exercise Induced ◽  
Atrial Natriuretic

Atrial natriuretic peptide stimulates lipid mobilization during repeated bouts of endurance exercise

2006 ◽  
Vol 290 (5) ◽  
pp. E864-E869 ◽  
Author(s):  
Cédric Moro ◽  
Jan Polak ◽  
Jindra Hejnova ◽  
Eva Klimcakova ◽  
François Crampes ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Rest Period ◽  
Ringer Solution ◽  
Glycerol Concentration ◽  
Lipid Mobilization ◽  
Underlying Mechanisms ◽  
Exercise Induced ◽  
Subcutaneous Adipose ◽  
Atrial Natriuretic

Atrial natriuretic peptide (ANP) controls lipolysis in human adipocytes. Lipid mobilization is increased during repeated bouts of exercise, but the underlying mechanisms involved in this process have not yet been delineated. The relative involvement of catecholamine- and ANP-dependent pathways in the control of lipid mobilization during repeated bouts of exercise was thus investigated in subcutaneous adipose tissue (SCAT) by microdialysis. The study was performed in healthy males. Subjects performed two 45-min exercise bouts (E1 and E2) at 50% of their maximal oxygen uptake separated by a 60-min rest period. Extracellular glycerol concentration (EGC), reflecting SCAT lipolysis, was measured in a control probe perfused with Ringer solution and in two other probes perfused with either Ringer plus phentolamine (α1/2-AR antagonist) or Ringer plus both phentolamine and propranolol (β-AR antagonist). Plasma epinephrine, plasma glycerol, and EGC were 1.7-, 1.6-, and 1.2-fold higher in E2 than in E1, respectively. Phentolamine potentiated exercise-induced EGC increase during E2 only. Propranolol reduced the lipolytic rate during both E1 and E2 compared with the probe with phentolamine. Plasma ANP concentration increased more during E2 than during E1 and was correlated with the increase in EGC in the probe containing phentolamine plus propranolol. The results suggest that ANP is involved in the control of lipolysis during exercise and that it contributes to stimulation of lipolysis during repeated bouts of exercise.

Plasma atrial natriuretic peptide during brief upright and supine exercise in humans

1989 ◽  
Vol 66 (5) ◽  
pp. 2159-2167 ◽  
Author(s):  
H. Perrault ◽  
M. Cantin ◽  
G. Thibault ◽  
G. R. Brisson ◽  
G. Brisson ◽  
...  
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Plasma Renin Activity ◽  
Natriuretic Peptide ◽  
Maximal Exercise ◽  
Plasma Renin ◽  
Renin Activity ◽  
Plasma Atrial Natriuretic Peptide ◽  
Plasma Vasopressin ◽  
Exercise Induced ◽  
Atrial Natriuretic

The factors associated with the exercise-induced increase in plasma atrial natriuretic peptide (ANP) have not been clearly established. Thus the purpose of the study was to further document the stimulus for the exercise-induced release of ANP and to examine the role of ANP in the control of hydromineral balance during exercise. Eight healthy male volunteers (25.1 +/- 4.5 yr) were submitted to a graded cycling exercise in both the upright and supine positions. Venous blood was sampled at rest and at the end of each 5-min work load at 40, 60, and 80% maximal oxygen uptake (Vo2max), at maximal exercise, and during recovery through an indwelling catheter for the determination of plasma vasopressin, aldosterone, catecholamines, plasma renin activity, and ANP concentrations. Results indicate a significant increase in ANP (pg/ml) from rest to maximal exercise in the upright position [rest, 21.9 +/- 10.2; 40%, 24.7 +/- 12.6; 60%, 32.4 +/- 17*; 80%, 47.8 +/- 27.7*; 100% Vo2max, 65.9 +/- 34.5* (*P less than or equal to 0.05)]. Supine concentrations were significantly higher than upright at 40 (37.9 +/- 15.2), 60 (54.0 +/- 18.8), and 80% Vo2max (68.9 +/- 16.6). Plasma ANP during maximal exercise was similar in both positions. Plasma vasopressin, aldosterone, renin activity, and catecholamines increased with increasing exercise intensity in both positions, although lower values were systematically observed in the supine position. The association of higher plasma ANP and blunted plasma vasopressin, plasma renin activity, and norepinephrine concentrations during supine exercise suggests that ANP may exert modulatory effects on the control of the hydromineral hormonal system during exercise.

Interactive effect of body posture on exercise-induced atrial natriuretic peptide release

1990 ◽  
Vol 258 (5) ◽  
pp. E775-E779 ◽  
Author(s):  
C. A. Ray ◽  
M. D. Delp ◽  
D. K. Hartle
Keyword(s):  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Interactive Effect ◽  
Peak Oxygen Uptake ◽  
Filling Pressure ◽  
Upright Position ◽  
Supine Posture ◽  
Blood Pressures ◽  
Exercise Induced ◽  
Atrial Natriuretic

The purpose of this investigation was to test the hypothesis that supine exercise elicits a greater atrial natriuretic peptide (ANP) response than upright exercise because of higher atrial filling pressure attained in the supine posture. Plasma ANP concentration ([ANP]) was measured during continuous graded supine and upright exercise in eight healthy men at rest after 4 min of cycling exercise at 31, 51, and 79% of posture-specific peak oxygen uptake (VO2 peak), after 2 min of cycling at posture-specific VO2 peak, and 5 and 15 min postexercise. [ANP] was significantly increased (P less than 0.05) above rest by 64, 140, and 228% during supine cycling at 51 and 79% and VO2 peak, respectively. During upright cycling, [ANP] was significantly increased (P less than 0.05) at 79% (60%) and VO2 peak (125%). After 15 min of postexercise rest, [ANP] remained elevated (P less than 0.05) only in the supine subjects. [ANP] was 63, 79, and 75% higher (P less than 0.05) in the supine than in the upright position during cycling at 51 and 79% and VO2 peak. Systolic, diastolic, and mean blood pressures were not significantly (P greater than 0.05) different between positions in all measurement periods. Heart rates were lower (P less than 0.05) in the supine position compared with the upright position. In conclusion, these results suggest that supine exercise elicits greater ANP release independent of blood pressure and heart rate but presumably caused by greater venous return, central blood volume, and concomitant atrial filling pressure and stretch.

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