Pupillary light reflex and quantitative sensory and motor neural function tests in diabetic patients

1988 ◽  
Vol 235 (4) ◽  
pp. 245-247 ◽  
Author(s):  
P. Lanting ◽  
J. J. Heimans ◽  
J. P. H. Reulen ◽  
J. Nauta ◽  
E. A. Veen
Keyword(s):  
Pupillary Light Reflex ◽  
Diabetic Patients ◽  
Neural Function ◽  
Light Reflex ◽  
Pupillary Light ◽  
Function Tests

scholarly journals Using System Identification to Construct an Inherent Model of Pupillary Light Reflex to Explore Diabetic Neuropathy

2021 ◽  
Vol 11 (7) ◽  
pp. 852
Author(s):  
Yung-Jhe Yan ◽  
Chien-Nan Chen ◽  
Mang Ou-Yang
Keyword(s):  
Nervous System ◽  
System Identification ◽  
Stimulus Duration ◽  
Physiological Mechanism ◽  
Pupillary Light Reflex ◽  
Diabetic Patients ◽  
Model Parameters ◽  
Light Reflex ◽  
Pupillary Light ◽  
Healthy Participants

This study proposed a pupillary light reflex (PLR) inherent model based on the system identification method to demonstrate the dynamic physiological mechanism of the PLR, in which pupillary constriction and dilation are controlled by the sympathetic and parasympathetic nervous system. This model was constructed and verified by comparing the simulated and predicted PLR response with that of healthy participants. The least root-mean-square error (RMSE) of simulated PLR response was less than 0.7% when stimulus duration was under 3 ms. The RMSE of predicted PLR response increased by approximately 6.76%/s from the stimulus duration of 1 ms to 3 s, when the model directly used the parameters extracted from the PLR at the stimulus duration of 10 ms. When model parameters were derived from the regression by the measured PLR response, the RMSE kept under 8.5%. The model was applied to explore the PLR abnormalities of the people with Diabetic Mellitus (DM) by extracting the model parameters from 42 people with DM and comparing these parameters with those of 42 healthy participants. The parameter in the first-order term of the elastic force of the participants with DM was significantly lower than that of the healthy participants (p < 0.05). The sympathetic force and sympathetic action delay of the participants with DM were significantly larger (p < 0.05) and longer (p < 0.0001) than that of the healthy ones, respectively. The reason might be that the sympathetic nervous system, which controls the dilator muscle, degenerated in diabetic patients.

scholarly journals Pupillary responses to single and sinusoidal light stimuli in diabetic patients

2009 ◽  
Vol 1 (1) ◽  
pp. 19 ◽  
Author(s):  
Wolfgang H. Zangemeister ◽  
Thilo Gronow ◽  
Ulrich Grzyska
Keyword(s):  
Autonomic Neuropathy ◽  
Pupillary Light Reflex ◽  
Diabetic Autonomic Neuropathy ◽  
Characteristic Change ◽  
Diabetic Patients ◽  
Frequency Content ◽  
Light Reflex ◽  
Pupillary Light ◽  
Pupillary Responses ◽  
Short Time

We examined effects of diabetes mellitus (DM) on the pupillary light reflex (PLR). Phasic pupillary response to a single light stimulus (200 ms) (pPLR) and to continuous sinusoidal stimuli with four different frequencies (0.1, 0.3, 0.7, 1.3Hz) (cPLR) were examined in 52 DM patients and 21 control subjects. We asked: does recording and frequency analysis of cPLR together with short time fourier [STFT] analysis of pPLR differentiate better between DM patients and normal subjects than pPLR only? Initial pupil diameter was significantly decreased in the DM group. For pPLR. maximal contraction velocity (Vmax), Vmax of redilation 1, reflex-amplitude and pPLR latency were significantly reduced in those patients who also showed signs of diabetic autonomic neuropathy (DNP). Tests of dynamic pupillary light reflex (cPLR) revealed that all DM patients had a significantly reduced gain at lower frequencies. Pupil phase lag was greater at 0.1 and 0.3Hz and smaller at 0.7 and 1.3 Hz in the DNP group (p<0.001). Comparison of single pPLR recordings of 5 DNP patients with 5 subjects using short time fast fourier (STFT) analysis revealed a characteristic change from low frequency content in healthy subjects to high frequency content in DNP patients. Significant changes in the PLR in DM can be found only when symptoms of autonomic neuropathy have been shown. Both sympathetic and the parasympathetic nervous systems are affected by diabetic autonomic neuropathy. Only recording of cPLR , together with STFT of pPLR can identify significant pathological deficits of pupillary control in single cases.

scholarly journals Effect of Topical Anti-Glaucoma Medications on Late Pupillary Light Reflex, as Evaluated by Pupillometry

2015 ◽  
Vol 6 ◽  
Author(s):  
Shakoor Ba-Ali ◽  
Birgit Sander ◽  
Adam Elias Brøndsted ◽  
Henrik Lund-Andersen
Keyword(s):  
Pupillary Light Reflex ◽  
Light Reflex ◽  
Pupillary Light
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