Structural brain correlates of anterograde memory deficits in multiple sclerosis

1988 ◽  
Vol 235 (6) ◽  
pp. 362-365 ◽  
Author(s):  
M. Brainin ◽  
G. Goldenberg ◽  
C. Ahlers ◽  
T. Reisner ◽  
A. Neuhold ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Memory Deficits ◽  
Brain Correlates ◽  
Structural Brain

Structural Brain Correlates of Neurourologic Abnormalities in Multiple Sclerosis

1992 ◽  
Vol 32 (4) ◽  
pp. 228-230 ◽  
Author(s):  
C. Pozzilli ◽  
M.G. Grasso ◽  
S. Bastianello ◽  
A. Anzini ◽  
M. Salvetti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Brain Correlates ◽  
Structural Brain

STRUCTURAL BRAIN CORRELATES OF EMOTIONAL DISORDER IN MULTIPLE SCLEROSIS

Brain ◽  
1986 ◽  
Vol 109 (4) ◽  
pp. 585-597 ◽  
Author(s):  
PETER V. RABINS ◽  
BENJAMIN R. BROOKS ◽  
PAT O'DONNELL ◽  
GODFREY D. PEARLSON ◽  
PAUL MOBERG ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Emotional Disorder ◽  
Brain Correlates ◽  
Structural Brain

Structural brain correlates of prepulse inhibition of the acoustic startle response in healthy humans

NeuroImage ◽  
2005 ◽  
Vol 26 (4) ◽  
pp. 1052-1058 ◽  
Author(s):  
Veena Kumari ◽  
Elena Antonova ◽  
Elizabeth Zachariah ◽  
Adrian Galea ◽  
Ingrid Aasen ◽  
...  
Keyword(s):  
Prepulse Inhibition ◽  
Startle Response ◽  
Acoustic Startle ◽  
Acoustic Startle Response ◽  
Healthy Humans ◽  
Brain Correlates ◽  
Structural Brain

scholarly journals Structural brain correlates of human sleep oscillations

NeuroImage ◽  
2013 ◽  
Vol 83 ◽  
pp. 658-668 ◽  
Author(s):  
Jared M. Saletin ◽  
Els van der Helm ◽  
Matthew P. Walker
Keyword(s):  
Human Sleep ◽  
Brain Correlates ◽  
Structural Brain

Structural brain correlates of resilience to traumatic stress in Dutch police officers

2017 ◽  
Vol 85 ◽  
pp. 172-178 ◽  
Author(s):  
Steven J.A. van der Werff ◽  
Bernet M. Elzinga ◽  
Annika S. Smit ◽  
Nic J.A. van der Wee
Keyword(s):  
Police Officers ◽  
Traumatic Stress ◽  
Brain Correlates ◽  
Structural Brain

scholarly journals Cortical morphology predicts placebo response in multiple sclerosis

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Mariya V. Cherkasova ◽  
Jessie F. Fu ◽  
Michael Jarrett ◽  
Poljanka Johnson ◽  
Shawna Abel ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Right Hemisphere ◽  
Placebo Response ◽  
Small World ◽  
Lesion Load ◽  
Transient Improvement ◽  
Related Quality ◽  
Brain Correlates ◽  
The Right ◽  
Multiple Sclerosis Patients

AbstractDespite significant insights into the neural mechanisms of acute placebo responses, less is known about longer-term placebo responses, such as those seen in clinical trials, or their interactions with brain disease. We examined brain correlates of placebo responses in a randomized trial of a then controversial and now disproved endovascular treatment for multiple sclerosis. Patients received either balloon or sham extracranial venoplasty and were followed for 48 weeks. Venoplasty had no therapeutic effect, but a subset of both venoplasty- and sham-treated patients reported a transient improvement in health-related quality of life, suggesting a placebo response. Placebo responders did not differ from non-responders in total MRI T2 lesion load, count or location, nor were there differences in normalized brain volume, regional grey or white matter volume or cortical thickness (CT). However, responders had higher lesion activity. Graph theoretical analysis of CT covariance showed that non-responders had a more small-world-like CT architecture. In non-responders, lesion load was inversely associated with CT in somatosensory, motor and association areas, precuneus, and insula, primarily in the right hemisphere. In responders, lesion load was unrelated to CT. The neuropathological process in MS may produce in some a cortical configuration less capable of generating sustained placebo responses.

scholarly journals The Structural Brain Correlates of Neurological Soft Signs in Healthy Individuals

2005 ◽  
Vol 16 (8) ◽  
pp. 1225-1231 ◽  
Author(s):  
Paola Dazzan ◽  
Kevin D. Morgan ◽  
Xavier Chitnis ◽  
John Suckling ◽  
Craig Morgan ◽  
...  
Keyword(s):  
Healthy Individuals ◽  
Neurological Soft Signs ◽  
Brain Correlates ◽  
Structural Brain

scholarly journals Stuck in a State of Inattention? Functional Hyperconnectivity as an Indicator of Disturbed Intrinsic Brain Dynamics in Adolescents With Concussion: A Pilot Study

ASN NEURO ◽  
2018 ◽  
Vol 10 ◽  
pp. 175909141775380 ◽  
Author(s):  
Angela M. Muller ◽  
Naznin Virji-Babul
Keyword(s):  
Diffusion Tensor Imaging ◽  
Pilot Study ◽  
Resting State ◽  
Diffusion Tensor ◽  
Brain Dynamics ◽  
Public Health Issue ◽  
Brain Correlates ◽  
Brain States ◽  
The Brain ◽  
Structural Brain

Sports-related concussion in youth is a major public health issue. Evaluating the diffuse and often subtle changes in structure and function that occur in the brain, particularly in this population, remains a significant challenge. The goal of this pilot study was to evaluate the relationship between the intrinsic dynamics of the brain using resting-state functional magnetic resonance imaging (rs-fMRI) and relate these findings to structural brain correlates from diffusion tensor imaging in a group of adolescents with sports-related concussions ( n = 6) and a group of healthy adolescent athletes ( n = 6). We analyzed rs-fMRI data using a sliding windows approach and related the functional findings to structural brain correlates by applying graph theory analysis to the diffusion tensor imaging data. Within the resting-state condition, we extracted three separate brain states in both groups. Our analysis revealed that the brain dynamics in healthy adolescents was characterized by a dynamic pattern, shifting equally between three brain states; however, in adolescents with concussion, the pattern was more static with a longer time spent in one brain state. Importantly, this lack of dynamic flexibility in the concussed group was associated with increased nodal strength in the left middle frontal gyrus, suggesting reorganization in a region related to attention. This preliminary report shows that both the intrinsic brain dynamics and structural organization are altered in networks related to attention in adolescents with concussion. This first report in adolescents will be used to inform future studies in a larger cohort.

Mesial temporal lobe and subcortical grey matter volumes differentially predict memory across stages of multiple sclerosis

2017 ◽  
Vol 24 (5) ◽  
pp. 675-678 ◽  
Author(s):  
James F Sumowski ◽  
Victoria M Leavitt ◽  
Maria A Rocca ◽  
Matilde Inglese ◽  
Gianna Riccitelli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Temporal Lobe ◽  
Grey Matter ◽  
Memory Deficits ◽  
Total Sample ◽  
Resonance Imaging ◽  
Total Brain ◽  
Mesial Temporal Lobe ◽  
Magnetic Resonance Imaging Mri ◽  
Disease Stages

Background/Objective: Memory deficits due to multiple sclerosis (MS) have been variably linked to lower subcortical grey matter (SCGM) and mesial temporal lobe (MTL) volumes. We investigated which is the better predictor and whether this changes across disease stages. Methods/Results: Memory was assessed in 315 patients. Magnetic resonance imaging (MRI) measured volumes of total brain, grey matter, white matter, MTL (hippocampus, amygdala) and SCGM (thalamus, caudate). MTL predicted memory in the total sample and in patients with earlier (<10 years) or later (⩾10 years) relapsing disease. SCGM (specifically thalamus) predicted memory in progressive patients. Conclusions: Neuroanatomical correlates of memory deficits differ across disease stages.

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