A syndrome resembling limbic encephalitis, associated with bronchial carcinoma, but without neuropathological abnormality: a case report

1984 ◽  
Vol 231 (3) ◽  
pp. 165-166 ◽  
Author(s):  
M. Delsedime ◽  
R. Cantello ◽  
L. Durelli ◽  
M. Gilli ◽  
M. T. Giordana ◽  
...  
Keyword(s):  
Case Report ◽  
Limbic Encephalitis ◽  
Bronchial Carcinoma

Voltage-gated potassium channel limbic encephalitis presenting as functional cognitive impairment

2020 ◽  
Vol 13 (12) ◽  
pp. e233179
Author(s):  
Eric Garrels ◽  
Fawziya Huq ◽  
Gavin McKay
Keyword(s):  
Cognitive Impairment ◽  
Case Report ◽  
Potassium Channel ◽  
Limbic Encephalitis ◽  
Psychiatric Symptoms ◽  
Differential Diagnoses ◽  
Visual Hallucinations ◽  
Voltage Gated ◽  
History Of ◽  
Impaired Cognition

Limbic encephalitis is often reported to present as seizures and impaired cognition with little focus on psychiatric presentations. In this case report, we present a 49-year-old man who initially presented to the Psychiatric Liaison Service with a several month history of confusion with the additional emergence of visual hallucinations and delusions. Due to the inconsistent nature of the symptoms in the context of a major financial stressor, a provisional functional cognitive impairment diagnosis was made. Investigations later revealed a positive titre of voltage-gated potassium channel (VGKC) antibodies, subtype leucine-rich glioma inactivated 1 accounting for his symptoms which dramatically resolved with steroids and immunoglobulins. This case highlighted the need for maintaining broad differential diagnoses in a patient presenting with unusual psychiatric symptoms.

scholarly journals Frontotemporal Dementia with Parkinsonism and Epilepsy Associated with VGKC Antibodies: Case Report and Literature Review

2021 ◽  
pp. 205-210
Author(s):  
Matthew Saint ◽  
Vafa Alakbarzade ◽  
Brendan McLean
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Frontotemporal Dementia ◽  
Limbic Encephalitis ◽  
Poor Response ◽  
Double Negative ◽  
Aggressive Treatment ◽  
Voltage Gated ◽  
Negative Results ◽  
Autoimmune Conditions

Antibodies directed against the voltage-gated potassium channel complex (anti-VGKCs) are implicated in several autoimmune conditions including limbic encephalitis and epilepsy. However, emerging evidence suggests that only specific subtypes of anti-VGKCs are pathogenic. We present the case of a 55-year-old man who initially presented with focal unaware seizures and behavioural changes mimicking anti-VGKC-seropositive encephalitis that further progressed to parkinsonism with evidence of frontotemporal dementia and pre-synaptic dopaminergic deficit. Aggressive treatment with immunotherapy was ineffective, and antibody subtyping later revealed the anti-VGKC antibodies to be negative for leucine-rich glioma-associated 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) – the two known pathogenic subtypes. The clinical relevance of so-called “double-negative” anti-VGKCs (i.e., those not directed towards LGI1 or CASPR2) has been called into question in recent years, with evidence to suggest they may be clinically insignificant. Our case emphasises the importance of antibody subtyping in cases of anti-VGKC seropositivity; negative results, particularly when combined with a poor response to immunotherapy, should prompt a rapid reconsideration of the working diagnosis.

scholarly journals Spontaneous right whole-lung torsion secondary to bronchial carcinoma: a case report

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Konstantina Chrysou ◽  
Konstantinos Gioutsos ◽  
Alexandra Filips ◽  
Roger Schmid ◽  
Ralph A. Schmid ◽  
...  
Keyword(s):  
Case Report ◽  
Bronchial Carcinoma ◽  
Lung Torsion

Positron Emission Tomography: False Positive Result Due to Splenic Uptake in an Extension Study in Bronchial Carcinoma. A Case Report

2007 ◽  
Vol 93 (3) ◽  
pp. 316-318
Author(s):  
David Orts Giménez ◽  
Rosa Jiménez Yáñez ◽  
Gaspar Esquerdo Galiana ◽  
Antonia Galán Dávila ◽  
Eleuterio Llorca Martínez ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Case Report ◽  
Positive Result ◽  
False Positive ◽  
Bronchial Carcinoma ◽  
Emission Tomography ◽  
Extension Study ◽  
False Positive Result ◽  
Positron Emission ◽  
Splenic Uptake

Metastatic disease of bronchial carcinoma in a thyroid nodule: a case report

2005 ◽  
Vol 262 (10) ◽  
pp. 804-806 ◽  
Author(s):  
Simon F. Preuss ◽  
Mark Stenzel ◽  
Torsten Hansen
Keyword(s):  
Case Report ◽  
Thyroid Nodule ◽  
Metastatic Disease ◽  
Bronchial Carcinoma
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