Effect of intensive immunosuppression on the course of chronic progressive multiple sclerosis

1980 ◽  
Vol 223 (3) ◽  
pp. 177-190 ◽  
Author(s):  
O. R. Hommes ◽  
K. J. B. Lamers ◽  
P. Reekers
Keyword(s):  
Multiple Sclerosis ◽  
Progressive Multiple Sclerosis ◽  
Chronic Progressive Multiple Sclerosis

Low-dose oral methotrexate in chronic progressive multiple sclerosis: Analyses of serial MRIs

Neurology ◽  
1996 ◽  
Vol 47 (5) ◽  
pp. 1153-1157 ◽  
Author(s):  
D.E. Goodkin ◽  
R.A. Rudick ◽  
S. V. Medendorp ◽  
M.M. Daughtry ◽  
C. Van Dyke
Keyword(s):  
Multiple Sclerosis ◽  
Low Dose ◽  
Progressive Multiple Sclerosis ◽  
Oral Methotrexate ◽  
Chronic Progressive Multiple Sclerosis ◽  
Dose Oral

Neuropsychological Studies in Chronic Progressive Multiple Sclerosis

1984 ◽  
Vol 436 (1 Multiple Scle) ◽  
pp. 495-497 ◽  
Author(s):  
STEPHEN M. RAO ◽  
THOMAS A. HAMMEKE ◽  
SANDER GLATT ◽  
MICHAEL P. McQUILLEN ◽  
B. O. KHATRI ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Progressive Multiple Sclerosis ◽  
Chronic Progressive Multiple Sclerosis

scholarly journals Safety and Tolerability of Subcutaneous Cladribine Therapy in Progressive Multiple Sclerosis

1998 ◽  
Vol 25 (4) ◽  
pp. 295-299 ◽  
Author(s):  
R. Selby ◽  
J. Brandwein ◽  
P. O'Connor
Keyword(s):  
Multiple Sclerosis ◽  
Lymphocyte Count ◽  
Antineoplastic Agent ◽  
Absolute Lymphocyte Count ◽  
Progressive Multiple Sclerosis ◽  
Disability Status ◽  
Chronic Progressive Multiple Sclerosis ◽  
Clinically Significant ◽  
One Year ◽  
Post Therapy

ABSTRACT:Objective:To evaluate the safety and tolerability of subcutaneous (s.c.) cladribine therapy in patients with chronic progressive multiple sclerosis (CPMS), and to evaluate the effects on lymphocyte subsets.Background:Cladribine, a synthetic antineoplastic agent with immunosuppressive effects, may favourably affect the course of CPMS. However results of a previous reported clinical trial showed significant myelosuppression in some patients.Design/Methods:19 patients with severe (mean extended disability status score [EDSS] = 6.7) CPMS were treated on a compassionate basis with cladribine 0.07 mg/kg/ day s.c. for 5 days per cycle, repeated every 4 weeks for a total of 6 cycles. Patients underwent clinical evaluation, EDSS, and hematologic analysis before, during, and following therapy.Results:The treatment was very well tolerated with no clinically significant side effects observed. Between baseline and the end of cycle 6, mean decreases were noted in absolute lymphocyte count from 1697 to 463 (p = 0.000012), CD4 count from 865 to 187 (p = 0.0000008), CD8 from 418 to 165 (p = 0.005) and CD19 from 197 to 26 (p = 0.000002). Platelet, granulocyte and RBC counts were unaffected. Approximately one year after completion of therapy, some recovery of CD4 and CD8 counts had occurred although both counts remained suppressed compared to baseline (302 and 227 respectively); the CD19 count had recovered essentially to normal by one year. EDSS scores post-therapy revealed some deterioration in 8 patients and stable scores in the remaining 11. Global patient evaluations of the treatment were mixed.Conclusions:Cladribine therapy, at lower doses than previously reported, was remarkably well tolerated in CPMS, with no significant myelosuppression. Profound effects occurred in total lymphocyte count and CD4, CD8 and CD19 subsets.

Preliminary trial of poly ICLC in chronic progressive multiple sclerosis

Neurology ◽  
1986 ◽  
Vol 36 (4) ◽  
pp. 494-498 ◽  
Author(s):  
C. Bever ◽  
A. Salazar ◽  
E Neely ◽  
B. Ferraraccio ◽  
J. Rose ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Progressive Multiple Sclerosis ◽  
Preliminary Trial ◽  
Chronic Progressive Multiple Sclerosis
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