Screening for abdominal aortic aneurysm and occlusive peripheral vascular disease in Japanese residents

Surgery Today ◽  
1995 ◽  
Vol 25 (7) ◽  
pp. 608-611 ◽  
Author(s):  
Hiroyuki Takei ◽  
Susumu Ishikawa ◽  
Akio Otaki ◽  
Kazuhiro Sakata ◽  
Masahiro Aizaki ◽  
...  
2003 ◽  
Vol 37 (2) ◽  
pp. 403-409 ◽  
Author(s):  
Koon-Sung Cheng ◽  
Alok Tiwari ◽  
Richard Morris ◽  
George Hamilton ◽  
Alexander M. Seifalian

Ultrasound ◽  
2018 ◽  
Vol 27 (2) ◽  
pp. 85-93
Author(s):  
Justyna Janus ◽  
Baris Kanber ◽  
Wadhah Mahbuba ◽  
Charlotte Beynon ◽  
Kumar V Ramnarine ◽  
...  

Introduction The efficacy of preclinical ultrasound at providing a quantitative assessment of mouse models of vascular disease is relatively unknown. In this study, preclinical ultrasound was used in combination with a semi-automatic image processing method to track arterial distension alterations in mouse models of abdominal aortic aneurysm and atherosclerosis. Methods Longitudinal B-mode ultrasound images of the abdominal aorta were acquired using a preclinical ultrasound scanner. Arterial distension was assessed using a semi-automatic image processing algorithm to track vessel wall motion over the cardiac cycle. A standard, manual analysis method was applied for comparison. Results Mean arterial distension was significantly lower in abdominal aortic aneurysm mice between day 0 and day 7 post-onset of disease (p < 0.01) and between day 0 and day 14 (p < 0.001), while no difference was observed in sham control mice. Manual analysis detected a significant decrease (p < 0.05) between day 0 and day 14 only. Atherosclerotic mice showed alterations in arterial distension relating to genetic modification and diet. Arterial distension was significantly lower (p < 0.05) in Ldlr−/− (++/−−) mice fed high-fat western diet when compared with both wild type (++/++) mice and Ldlr−/− (++/−−) mice fed chow diet. The manual method did not detect a significant difference between these groups. Conclusions Arterial distension can be used as an early marker for the detection of arterial disease in murine models. The semi-automatic analysis method provided increased sensitivity to differences between experimental groups when compared to the manual analysis method.


Author(s):  
Mark A. Creager

Atherosclerosis is a systemic disorder with regional manifestations in the heart, limbs, brain, and other organs. Advances in vascular biology, diagnostic imaging, pharmacotherapeutics, and intervention have provided physicians with greater opportunities to evaluate and manage patients with atherosclerotic vascular diseases. This chapter reviews several of these peripheral vascular diseases, including peripheral artery disease, abdominal aortic aneurysm, and carotid artery disease.


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