Parathyroid hormone-related protein: Primary osteolytic factor produced by breast tumor cells in vitro?

1995 ◽  
Vol 19 (2) ◽  
pp. 292-297 ◽  
Author(s):  
Arnold Tabuenca ◽  
Subburaman Mohan ◽  
Carlos A. Garberoglio ◽  
Patrick I. Borgen ◽  
Thomas Rosol ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Tumor Cells ◽  
Breast Tumor ◽  
Related Protein ◽  
Breast Tumor Cells ◽  
Parathyroid Hormone Related Protein

In vitro model of parathyroid hormone-related protein secretion from mammary cells isolated from lactating cows

1996 ◽  
Vol 13 (5) ◽  
pp. 399-410 ◽  
Author(s):  
H. Okada ◽  
F.L. Schanbacher ◽  
L.K. McCauley ◽  
M.T. Weckmann ◽  
C.C. Capen ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Protein Secretion ◽  
In Vitro Model ◽  
Mammary Cells ◽  
Related Protein ◽  
Lactating Cows ◽  
Parathyroid Hormone Related Protein ◽  
Vitro Model

Evidence for the synthesis of parathyroid hormone-related protein (PTHrP) by nontransformed clonal rat osteoblastic cells in vitro

Bone ◽  
1995 ◽  
Vol 16 (3) ◽  
pp. 341-347 ◽  
Author(s):  
H.L. Guenther ◽  
W. Hofstetter ◽  
J.M. Moseley ◽  
M.T. Gillespie ◽  
N. Suda ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Osteoblastic Cells ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein

scholarly journals Parathyroid hormone-related protein regulates intestinal calcium transport in sea bream (Sparus auratus)

2006 ◽  
Vol 291 (5) ◽  
pp. R1499-R1506 ◽  
Author(s):  
Juan Fuentes ◽  
Joana Figueiredo ◽  
Deborah M. Power ◽  
Adelino V. M. Canário
Keyword(s):  
Parathyroid Hormone ◽  
Calcium Transport ◽  
Calcium Uptake ◽  
Sea Bream ◽  
Whole Body ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein ◽  
Intestinal Calcium Transport ◽  
Sparus Auratus

Parathyroid hormone-related protein (PTHrP) is a factor associated with normal development and physiology of the nervous, cardiovascular, immune, reproductive, and musculoskeletal systems in higher vertebrates. It also stimulates whole body calcium uptake in sea bream ( Sparus auratus) larvae with an estimated 60% coming from intestinal uptake in seawater. The present study investigated the role of PTHrP in the intestinal calcium transport in the sea bream in vitro. Unidirectional mucosal-to-serosal and serosal-to-mucosal 45Ca fluxes were measured in vitro in duodenum, hindgut, and rectum mounted in Ussing chambers. In symmetric conditions with the same saline, bathing apical and basolateral sides of the preparation addition of piscine PTHrP 1–34 (6 nM) to the serosal surface resulted in an increase in mucosal to serosal calcium fluxes in duodenum and hindgut and a reduction in serosal to mucosal in the rectum, indicating that different mechanisms are responsive to PTHrP along the intestine. In control asymmetric conditions, with serosal normal and mucosal bathed with a saline similar in composition to the intestinal fluid, there was a net increase in calcium uptake in all regions. The addition of 6 nM PTHrP 1–34 increased net calcium uptake two- to threefold in all regions. The stimulatory effect of PTHrP on net intestinal calcium absorption is consistent with a hypercalcemic role for the hormone. The results support the view that PTHrP, alone or in conjunction with recently identified PTH-like peptides, counteracts in vivo the hypocalcemic effects of stanniocalcin.

scholarly journals TGFBI expression reduces in vitro and in vivo metastatic potential of lung and breast tumor cells

2011 ◽  
Vol 308 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Gengyun Wen ◽  
Michael A. Partridge ◽  
Bingyan Li ◽  
Mei Hong ◽  
Wupeng Liao ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Breast Tumor ◽  
Metastatic Potential ◽  
Breast Tumor Cells

scholarly journals High-Affinity HLA-A(*)02.01 Peptides from Parathyroid Hormone-Related Protein Generate In Vitro and In Vivo Antitumor CTL Response Without Autoimmune Side Effects

2002 ◽  
Vol 169 (9) ◽  
pp. 4840-4849 ◽  
Author(s):  
Guido Francini ◽  
Antonio Scardino ◽  
Kostas Kosmatopoulos ◽  
François A. Lemonnier ◽  
Giuseppe Campoccia ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Side Effects ◽  
Related Protein ◽  
Ctl Response ◽  
High Affinity ◽  
Parathyroid Hormone Related Protein

Breast tumor cells isolated from in vitro resistance to trastuzumab remain sensitive to trastuzumab anti-tumor effects in vivo and to ADCC killing

2009 ◽  
Vol 58 (11) ◽  
pp. 1887-1896 ◽  
Author(s):  
Timothy E. Kute ◽  
Lori Savage ◽  
John R. Stehle ◽  
Jung W. Kim-Shapiro ◽  
Michael J. Blanks ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Breast Tumor ◽  
Breast Tumor Cells

Mechanical stimuli induce vascular parathyroid hormone-related protein gene expression in vivo and in vitro.

Endocrinology ◽  
1994 ◽  
Vol 134 (5) ◽  
pp. 2230-2236 ◽  
Author(s):  
C J Pirola ◽  
H M Wang ◽  
M I Strgacich ◽  
A Kamyar ◽  
B Cercek ◽  
...  
Keyword(s):  
Gene Expression ◽  
Parathyroid Hormone ◽  
Protein Gene ◽  
Mechanical Stimuli ◽  
Related Protein ◽  
Parathyroid Hormone Related Protein
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