Choroid plexus papillomas in infancy and childhood

1990 ◽  
Vol 6 (2) ◽  
pp. 71-74 ◽  
Author(s):  
A. Spallone ◽  
F. S. Pastore ◽  
R. Giuffre ◽  
B. Guidetti
Keyword(s):  
Choroid Plexus ◽  
Infancy And Childhood ◽  
Choroid Plexus Papillomas

Consistent aneuploidies in choroid plexus papillomas

1999 ◽  
Vol 24 (3) ◽  
pp. 293-293 ◽  
Author(s):  
Hope H. Punnett ◽  
Jean-Pierre de Chadarevian ◽  
Ewa Z. Tomczak
Keyword(s):  
Choroid Plexus ◽  
Choroid Plexus Papillomas

scholarly journals Choroid plexus papillomas of the cerebellopontine angle in a child

1986 ◽  
Vol 7 (6) ◽  
pp. 613-616 ◽  
Author(s):  
A. Spallone ◽  
F. S. Pastore ◽  
Mao O. Hagi
Keyword(s):  
Choroid Plexus ◽  
Cerebellopontine Angle ◽  
Choroid Plexus Papillomas

scholarly journals Immunohistochemical Study for Choroid Plexus Papillomas and Ependymomas

1991 ◽  
Vol 31 (13) ◽  
pp. 859-866 ◽  
Author(s):  
Katsuzo KUNISHIO ◽  
Tetsuya SHIRAISHI ◽  
Nobuya MISHIMA ◽  
Nobuhiko MATSUMI ◽  
Toru SATOH ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Immunohistochemical Study ◽  
Choroid Plexus Papillomas

Choroid plexus papillomas - Neuroradiological diagnosis

1982 ◽  
Vol 25 (05) ◽  
pp. 165-169
Author(s):  
A. Spallone ◽  
G. Guidetti ◽  
S. Mercuri ◽  
A. Russo ◽  
A. Ierardi ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Neuroradiological Diagnosis ◽  
Choroid Plexus Papillomas

scholarly journals TBIO-25. CHOROID PLEXUS PAPILLOMAS IN FAMILIES WITH DICER1 MUTATION ASSOCIATED DISEASE

2018 ◽  
Vol 20 (suppl_2) ◽  
pp. i185-i185
Author(s):  
Barbara Rivera ◽  
Anne-Sophie Chong ◽  
Christian Thomas ◽  
Sommayeh Fahiminiya ◽  
Doug Strother ◽  
...  
Keyword(s):  
Choroid Plexus ◽  
Choroid Plexus Papillomas

scholarly journals Choroid plexus papillomas are induced by c-Myc overexpression in the choroid plexus via a T-cell inflammatory mechanism

2019 ◽  
Vol 21 (Supplement_4) ◽  
pp. iv9-iv10
Author(s):  
Ashirwad Merve ◽  
Xinyu Zhang ◽  
Nicola Pomella ◽  
Serena Acquati ◽  
Joerg Hoeck ◽  
...  
Keyword(s):  
T Cell ◽  
Mouse Model ◽  
Choroid Plexus ◽  
Tumour Size ◽  
Choroid Plexus Papilloma ◽  
Experimental Models ◽  
Chemotherapeutic Agents ◽  
Human Choroid Plexus ◽  
Choroid Plexus Papillomas ◽  
Plexus Papilloma

Abstract Choroid plexus tumours (CPT) account for up to 20% of brain tumours in children under 2 years of age. Histologically CPTs are classified into three categories - Choroid Plexus Papilloma (CPP), Atypical Choroid Plexus Papilloma (ACPP) and Choroid Plexus Carcinoma (CPC). Recent literature demonstrates that CPP and ACPP are molecularly distinct from CPC. Initial management for CPT include surgery followed by adjuvant therapy in selected patients. Currently there are no disease-specific chemotherapeutic agents available, possibly because of their rarity and paucity of faithful pre-clinical experimental models. In this study we show that c-Myc overexpression in the choroid plexus epithelium induces T-cell inflammation-dependent choroid plexus papillomas in a mouse model. We demonstrate that c-MYC is expressed in a substantial proportion of human choroid plexus tumours and that this subgroup of tumours is characterised by an inflammatory transcriptome and significant inflammatory infiltrates. We observed that triple transgenic compound mutant mouse model with c-Myc overexpression in an immune-suppressed background led to a decreased incidence of CPP and reduced tumour bulk. A reduced tumour size was also observed when c-Myc overexpressing mice were treated with anti-CD3 antibodies. Our data raise the possibility that benign choroid plexus tumours expressing c-MYC could be amenable to medical therapy with anti-inflammatory drugs.

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