Isolation and characterization of neurosecretory granules of the rat posterior pituitary gland

1972 ◽  
Vol 129 (1) ◽  
pp. 92-113 ◽  
Author(s):  
A. Norstr�m ◽  
H. -A. Hansson
Keyword(s):  
Pituitary Gland ◽  
Posterior Pituitary ◽  
Neurosecretory Granules ◽  
Isolation And Characterization ◽  
Posterior Pituitary Gland

scholarly journals Comprehensive Genomic Characterization of A Case of Granular Cell Tumor of the Posterior Pituitary Gland: A Case Report

2021 ◽  
Vol 12 ◽  
Author(s):  
Christopher S. Hong ◽  
Aladine A. Elsamadicy ◽  
Adeniyi Fisayo ◽  
Silvio E. Inzucchi ◽  
Pallavi P. Gopal ◽  
...  
Keyword(s):  
Pituitary Gland ◽  
Exome Sequencing ◽  
Granular Cell Tumor ◽  
Granular Cell ◽  
Cell Tumor ◽  
Posterior Pituitary ◽  
Whole Exome ◽  
Genomic Characterization ◽  
Posterior Pituitary Gland

Granular cell tumors of the pituitary belong to a rare family of neoplasms, arising from the posterior pituitary gland. Although considered benign, they may cause significant morbidity and residual disease after resection can lead to poor clinical outcomes. Currently, there is no known medical therapy for any posterior pituitary gland tumor, in part due to sparse molecular characterization of these lesions. We report data from whole exome sequencing of a case of granular cell tumor of the pituitary, performed under an institutional review board approved protocol. A 77 year-old female underwent resection of an incidentally diagnosed pituitary mass that was causing radiographic compression of the optic nerves with a subclinical temporal field defect and central hypothyroidism. The pathology of the resected specimen demonstrated a granular cell tumor of the posterior pituitary gland. Whole-exome sequencing revealed mutations predicted to be deleterious in key oncogenes, SETD2 and PAX8, both of which have been described in other cancers and could potentially be amenable to targeted therapies with existing approved drugs, including immune checkpoint inhibitors and histone deacetylase inhibitors, respectively. To our knowledge, this is the first comprehensive genomic characterization of granular cell tumor of the posterior pituitary gland. We report mutations in oncogenes predicted to be deleterious and reported in other cancers with potential for therapeutic targeting with existing pharmacologic agents. These data provide new insights into the molecular pathogenesis of GCT of the pituitary and may warrant further investigation.

Pathophysiological roles of galanin-like peptide in the hypothalamus and posterior pituitary gland

2010 ◽  
Vol 17 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Hitoshi Suzuki ◽  
Tatsushi Onaka ◽  
Govindan Dayanithi ◽  
Yoichi Ueta
Keyword(s):  
Pituitary Gland ◽  
Posterior Pituitary ◽  
Posterior Pituitary Gland

Vasopressin Concentrations in Hypophysial Portal Plasma: Insignificant Reduction following Removal of the Posterior Pituitary Gland

1981 ◽  
Vol 33 (2) ◽  
pp. 88-90 ◽  
Author(s):  
Larry D. Recht ◽  
Donald L. Hoffman ◽  
Jaya Haldar ◽  
Ann-Judith Silverman ◽  
Earl A. Zimmerman
Keyword(s):  
Pituitary Gland ◽  
Posterior Pituitary ◽  
Portal Plasma ◽  
Posterior Pituitary Gland ◽  
Hypophysial Portal

Serotonergic Neurons and Neuroendocrine Function

Physiology ◽  
1993 ◽  
Vol 8 (5) ◽  
pp. 202-207
Author(s):  
LD Van de Kar ◽  
MS Brownfield
Keyword(s):  
Pituitary Gland ◽  
Anterior Pituitary ◽  
Adrenocorticotropic Hormone ◽  
Renin Secretion ◽  
Nerve Terminals ◽  
Posterior Pituitary ◽  
Serotonergic Neurons ◽  
Neuroendocrine Function ◽  
Posterior Pituitary Gland

The release of serotonin (5-HT) from nerve terminals in the hypothalamus increases secretion of adrenocorticotropic hormone and prolactin from the anterior pituitary, vasopressin and oxytocin from the posterior pituitary gland, and renin secretion from the kidneys. Activation of 5-HT1 and/or 5-HT2 receptors stimulates the secretion of these hormones.

Cushing’s disease due to mixed pituitary adenoma-gangliocytoma of the posterior pituitary gland presenting with Aspergillus sp. sinus infection

2013 ◽  
Vol 32 (09) ◽  
pp. 377-383 ◽  
Author(s):  
Mark Bridenstine ◽  
Janice M. Kerr ◽  
Kevin O. Lillehei ◽  
Bette K. Kleinschmidt-DeMasters
Keyword(s):  
Pituitary Adenoma ◽  
Pituitary Gland ◽  
Posterior Pituitary ◽  
Sinus Infection ◽  
Posterior Pituitary Gland ◽  
Aspergillus Sp
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