On the fine structure of alteration of the adrenal cortex in hypophysectomized rats

1972 ◽  
Vol 125 (4) ◽  
pp. 480-496 ◽  
Author(s):  
Hisao Fujita
Keyword(s):  
Fine Structure ◽  
Adrenal Cortex ◽  
Hypophysectomized Rats

Fine structure of the adrenal cortex

1984 ◽  
pp. 189-200 ◽  
Author(s):  
Gastone G. Nussdorfer ◽  
Virgilio Meneghelli ◽  
Giuseppina Mazzocchi
Keyword(s):  
Fine Structure ◽  
Adrenal Cortex

PHOSPHORUS METABOLISM OF THE LIVER: EFFECT OF HYPOPHYSECTOMY, ADRENALECTOMY, AND ADMINISTRATIONOF ACTH ON THE INCORPORATION OF RADIOACTIVE PHOSPHATE INTO RNA NUCLEOTIDES

1955 ◽  
Vol 33 (1) ◽  
pp. 54-61 ◽  
Author(s):  
J. E. Logan ◽  
F. C. Heagy ◽  
R. J. Rossiter
Keyword(s):  
Adrenal Cortex ◽  
Intraperitoneal Injection ◽  
Inorganic Phosphate ◽  
Adrenal Glands ◽  
Specific Activity ◽  
Phosphorus Metabolism ◽  
Relative Specific Activity ◽  
Hypophysectomized Rats

The specific activity of the liver RNA nucleotide phosphorus, relative to the specific activity of the liver inorganic phosphate, was determined in the rat, 16 hr. after an intraperitoneal injection of radioactive inorganic phosphate. The nucleotides were isolated by ionophoresis on paper strips.Hypophysectomy caused a decrease in the relative specific activity of each of the four RNA nucleotides. The administration of ACTH caused an increase in the incorporation of P32 into each of the RNA nucleotides of the liver of hypophysectomized animals, but it caused a small and statistically significant decrease in normal animals. Adrenalectomy, either in normal or in hypophysectomized rats, did not affect the P32 incorporation, nor did the administration of ACTH in the absence of the adrenal glands.It is concluded that ACTH can affect the incorporation of P32 into the RNA of the liver and that this effect is due to the action of the hormone on the adrenal cortex. However, other factors also must be operative, since removal of the adrenal glands does not cause the decrease in the P32 incorporation observed after removal of the pituitary.

“IN VIVO” AND “IN VITRO” EFFECT OF ASCORBIC ACID AND ACTH ON THE RAT ADRENAL CORTEX

1952 ◽  
Vol 30 (3) ◽  
pp. 157-162
Author(s):  
A. DesMarais ◽  
J. Leblanc
Keyword(s):  
Ascorbic Acid ◽  
Adrenal Cortex ◽  
Adrenal Glands ◽  
Secretory Activity ◽  
In Vitro Experiments ◽  
Hypophysectomized Rats ◽  
Vitro Effect ◽  
Histochemical Examination

Histochemical examination of adrenal glands of hypophysectomized rats given both ascorbic acid and ACTH showed an enlargement of the cortex and a decrease of sudanophilic substances, as compared to adrenals of hypophysectomized rats receiving ACTH alone. “In vitro” experiments on incubated slices of adrenal glands have shown that ascorbic acid and ACTH have a synergistic effect on the secretory activity of the cells of the adrenal cortex.

scholarly journals OBSERVATIONS ON THE INFLUENCE OF THE HYPOPHYSIS AND THE ADRENAL CORTEX ON BLOOD PLATELET LEVELS

Blood ◽  
1949 ◽  
Vol 4 (8) ◽  
pp. 936-946 ◽  
Author(s):  
ELIJAH ADAMS
Keyword(s):  
Bone Marrow ◽  
Adrenal Cortex ◽  
Blood Platelets ◽  
Blood Platelet ◽  
Distilled Water ◽  
Hypophysectomized Rats ◽  
Physiologic Saline ◽  
Maximum Rise ◽  
Adrenalectomized Rats ◽  
Intact Rats

Abstract Observations were made to investigate possible endocrine influences on blood platelets. Adrenal cortex extract failed to influence the platelet counts of mice, rats, or rabbits. Adrenalectomy and sham-adrenalectomy were followed by almost identical platelet increases in mice and rats. Administration of adrenal cortex extract, or physiologic saline, to adrenalectomized rats was followed by a consistent fall in platelets not observed in sham-adrenalectomized rats, or after administering distilled water to adrenalectomized rats. Platelet levels in hypophysectomized rats were significantly lower than in unoperated controls. Splenectomy in hypophysectomized rats was followed by a maximum rise in platelets markedly lower than following splenectomy in intact rats. Bone-marrow megakaryocytes in hypophysectomized rats were significantly fewer than in intact rats. No changes in megakaryocyte number or morphology appeared following splenectomy either in intact or hypophysectomized rats.

Fine structure of the rabbit adrenal cortex and the effects of short-term ACTH administration

1979 ◽  
Vol 201 (2) ◽  
Author(s):  
G. Mazzocchi ◽  
A.S. Belloni ◽  
P. Rebuffat ◽  
C. Robba ◽  
G. Neri ◽  
...  
Keyword(s):  
Fine Structure ◽  
Adrenal Cortex ◽  
Short Term

The fine structure of the adrenal cortex of the 13-lined ground squirrel

1968 ◽  
Vol 123 (2) ◽  
pp. 297-313 ◽  
Author(s):  
William G. Seliger ◽  
Wayne F. Smith
Keyword(s):  
Fine Structure ◽  
Adrenal Cortex ◽  
Ground Squirrel

scholarly journals Effects of Pituitary and Adrenal Hormones on the Numbers of Thoracic Duct Lymphocytes

Blood ◽  
1952 ◽  
Vol 7 (2) ◽  
pp. 193-206 ◽  
Author(s):  
GERALD F. HUNGERFORD ◽  
WILLIAM O. REINHARDT ◽  
CHOH HAO LI
Keyword(s):  
Growth Hormone ◽  
Adrenal Cortex ◽  
Thoracic Duct ◽  
Anterior Pituitary ◽  
Cortisone Acetate ◽  
Adrenal Hormones ◽  
Peptide Mixture ◽  
Peptide Mixtures ◽  
Hypophysectomized Rats ◽  
Adrenalectomized Rats

Abstract The endocrine influences of hypophysectomy, adrenalectomy, and the administration of pituitary and adrenal hormones on the level of thoracic duct lymphocytes have been studied in test animals under standardized conditions. The following effects have been noted: 1. Numbers of thoracic duct lymphocytes are elevated after either hypophysectomy or adrenalectomy in the rat. 2. After the administration of either ACTH protein or pepsin peptide mixtures to normal or hypophysectomized rats, the number of thoracic duct lymphocytes is significantly reduced. This effect was not noted in adrenalectomized rats. These effects were observed two hours after administration of the ACTH preparations. If a shorter time elapsed, no effect was noted with the ACTH protein, nor was any effect noted with an ACTH acid peptide mixture under the conditions employed. 3. Administration of epinephrine to normal or hypophysectomized rats, singly or in combination with ACTH protein (in which case its effect was potentiated), produced a significant reduction in the number of thoracic duct lymphocytes. This effect was not observed in the adrenalectomized rat, suggesting that epinephrine may act directly in producing this effect. 4. Growth hormone (beef anterior pituitary), Pitressin, Pitocin, Adrenal Cortex Extract, cortisone acetate, and desoxycorticosterone glucoside did not alter the levels of thoracic duct lymphocytes under the conditions of these experiments.

PHOSPHORUS METABOLISM OF THE LIVER: EFFECT OF HYPOPHYSECTOMY, ADRENALECTOMY, AND ADMINISTRATIONOF ACTH ON THE INCORPORATION OF RADIOACTIVE PHOSPHATE INTO RNA NUCLEOTIDES

1955 ◽  
Vol 33 (1) ◽  
pp. 54-61
Author(s):  
J. E. Logan ◽  
F. C. Heagy ◽  
R. J. Rossiter
Keyword(s):  
Adrenal Cortex ◽  
Intraperitoneal Injection ◽  
Inorganic Phosphate ◽  
Adrenal Glands ◽  
Specific Activity ◽  
Phosphorus Metabolism ◽  
Relative Specific Activity ◽  
Hypophysectomized Rats

The specific activity of the liver RNA nucleotide phosphorus, relative to the specific activity of the liver inorganic phosphate, was determined in the rat, 16 hr. after an intraperitoneal injection of radioactive inorganic phosphate. The nucleotides were isolated by ionophoresis on paper strips.Hypophysectomy caused a decrease in the relative specific activity of each of the four RNA nucleotides. The administration of ACTH caused an increase in the incorporation of P32 into each of the RNA nucleotides of the liver of hypophysectomized animals, but it caused a small and statistically significant decrease in normal animals. Adrenalectomy, either in normal or in hypophysectomized rats, did not affect the P32 incorporation, nor did the administration of ACTH in the absence of the adrenal glands.It is concluded that ACTH can affect the incorporation of P32 into the RNA of the liver and that this effect is due to the action of the hormone on the adrenal cortex. However, other factors also must be operative, since removal of the adrenal glands does not cause the decrease in the P32 incorporation observed after removal of the pituitary.

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