Covariance between relatives for X-chromosomal loci in a population in disequilibrium

1989 ◽  
Vol 77 (3) ◽  
pp. 311-319 ◽  
Author(s):  
M. Grossman ◽  
R. L. Fernando
Keyword(s):  
Covariance Between Relatives ◽  
Chromosomal Loci

scholarly journals Short-Time Dynamics E. Coli Chromosomal Loci Reveal a Dependence on Coordinate and Indicate the Presence of a Sporadic but Ubiquitous Super-Diffusive Motion

2014 ◽  
Vol 106 (2) ◽  
pp. 78a
Author(s):  
Avelino Javer ◽  
Zhicheng Long ◽  
Nathan J. Kuwada ◽  
Eileen Nugent ◽  
Marco Grisi ◽  
...  
Keyword(s):  
Diffusive Motion ◽  
Time Dynamics ◽  
E Coli ◽  
Short Time ◽  
Chromosomal Loci

scholarly journals Sex-biased migration and admixture in macaque species revealed by comparison between autosomal and X-chromosomal genomic sequences

2020 ◽  
Author(s):  
Naoki Osada ◽  
Kazunari Matsudaira ◽  
Yuzuru Hamada ◽  
Suchinda Malaivijitnond
Keyword(s):  
Genomic Diversity ◽  
Hybrid Origin ◽  
Mitochondrial Genomes ◽  
Whole Genome ◽  
Genome Sequences ◽  
X Chromosomes ◽  
Specific Hybridization ◽  
Predominantly Female ◽  
Chromosomal Loci

AbstractThe role of sex-specific demography in hybridization and admixture of genetically diverged species and populations is essential to understand the mechanisms forming the genomic diversity of sexually reproducing organisms. In order to infer how sex-linked genetic loci have been differentiated undergoing frequent hybridization and admixture, we examined 17 whole-genome sequences of seven species of the genus Macaca, which shows frequent inter-specific hybridization and predominantly female philopatry. We found that hybridization and admixture were prevalent within these species. For three cases of suggested hybrid origin of species/subspecies, M. arctoides, M. fascicularis ssp. aurea, and Chinese M. mulatta, we examined the level of admixture of X chromosomes, which is less affected by male-biased migration than that of autosomes. In one case, we were able to determine that M. cyclopis and M. fuscata was genetically closer to Chinese M. mulatta than to the Indian M. mulatta, and the admixture level of Chinese M. mulatta and M. fuscata/cyclopis was more pronounced on the X chromosome than on autosomes. Since the mitochondrial genomes of Chinese M. mulatta, M. cyclopis, and M. fuscata were found to cluster together, and the mitochondrial genome of Indian M. mulatta is more distantly related, the observed pattern of genetic differentiation on X-chromosomal loci is consistent with the nuclear swamping hypothesis, in which strong, continuous male-biased introgression from the ancestral Chinese M. mulatta population to a population related to M. fuscata and M. cyclopis generated incongruencies between the genealogies of the mitochondrial and autosomal genomes.

Allelic imbalance at chromosomal loci implicated in the pathogenesis of oral precancer, cumulative loss and its relationship with progression to cancer

Oral Oncology ◽  
1998 ◽  
Vol 34 (2) ◽  
pp. 77-83 ◽  
Author(s):  
M. Partridge ◽  
G. Emilion ◽  
S. Pateromichelakis ◽  
R. A'Hern ◽  
E. Phillips ◽  
...  
Keyword(s):  
Allelic Imbalance ◽  
Oral Precancer ◽  
Chromosomal Loci

scholarly journals Mutational Analysis of Metronidazole Resistance in Helicobacter pylori

2005 ◽  
Vol 49 (3) ◽  
pp. 1236-1237 ◽  
Author(s):  
Jill M. Moore ◽  
Nina R. Salama
Keyword(s):  
Helicobacter Pylori ◽  
Mutational Analysis ◽  
Transposon Mutagenesis ◽  
Human Stomach ◽  
Metronidazole Resistance ◽  
H Pylori ◽  
Chromosomal Loci

ABSTRACT Metronidazole is one of a few antibiotics effective in eliminating Helicobacter pylori infection of the human stomach. Several chromosomal loci have been implicated in resistance to this drug. Saturation transposon mutagenesis of the H. pylori genome revealed inactivation of the rdxA gene as uniquely able to confer metronidazole resistance.

scholarly journals Bacterial Chromosomal Loci Move Subdiffusively through a Viscoelastic Cytoplasm

2010 ◽  
Vol 104 (23) ◽  
Author(s):  
Stephanie C. Weber ◽  
Andrew J. Spakowitz ◽  
Julie A. Theriot
Keyword(s):  
Chromosomal Loci

scholarly journals Precise Excision and Self-Integration of a Composite Transposon as a Model for Spontaneous Large-Scale Chromosome Inversion/Deletion of the Staphylococcus haemolyticus Clinical Strain JCSC1435

2007 ◽  
Vol 189 (7) ◽  
pp. 2921-2925 ◽  
Author(s):  
Shinya Watanabe ◽  
Teruyo Ito ◽  
Yuh Morimoto ◽  
Fumihiko Takeuchi ◽  
Keiichi Hiramatsu
Keyword(s):  
Large Scale ◽  
Chromosome Rearrangements ◽  
Clinical Strain ◽  
Beta Lactam ◽  
Chromosome Inversion ◽  
Chromosomal Inversions ◽  
Precise Excision ◽  
Staphylococcus Haemolyticus ◽  
Drug Free ◽  
Chromosomal Loci

ABSTRACT Large-scale chromosomal inversions (455 to 535 kbp) or deletions (266 to 320 kbp) were found to accompany spontaneous loss of beta-lactam resistance during drug-free passage of the multiresistant Staphylococcus haemolyticus clinical strain JCSC1435. Identification and sequencing of the rearranged chromosomal loci revealed that ISSha1 of S. haemolyticus is responsible for the chromosome rearrangements.

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