The embryonic development of the cerebellum in normal and reeler mutant mice

1983 ◽  
Vol 168 (1) ◽  
pp. 73-86 ◽  
Author(s):  
A. M. Goffinet
Keyword(s):  
Embryonic Development ◽  
Mutant Mice ◽  
Reeler Mutant

Multiple developmental defects in Engrailed-1 mutant mice: an early mid-hindbrain deletion and patterning defects in forelimbs and sternum

Development ◽  
1994 ◽  
Vol 120 (7) ◽  
pp. 2065-2075 ◽  
Author(s):  
W. Wurst ◽  
A.B. Auerbach ◽  
A.L. Joyner
Keyword(s):  
Spinal Cord ◽  
Embryonic Development ◽  
Normal Development ◽  
Cranial Nerves ◽  
Mutant Mice ◽  
Mouse Development ◽  
Developmental Defects ◽  
Targeted Deletion ◽  
The Third ◽  
A Cell

During mouse development, the homeobox-containing gene En-1 is specifically expressed across the mid-hindbrain junction, the ventral ectoderm of the limb buds, and in regions of the hindbrain, spinal cord, somites and somite-derived tissues. To address the function of En-1 during embryogenesis, we have generated mice homozygous for a targeted deletion of the En-1 homeobox. En-1 mutant mice died shortly after birth and exhibited multiple developmental defects. In the brains of newborn mutants, most of the colliculi and cerebellum were missing and the third and fourth cranial nerves were absent. A deletion of midhindbrain tissue was observed as early as 9.5 days of embryonic development and the phenotype resembles that previously reported for Wnt-1 mutant mice. In addition, patterning of the forelimb paws and sternum was disrupted, and the 13th ribs were truncated. The results of these studies suggest a cell autonomous role for En-1 in generation and/or survival of mid-hindbrain precursor cells and also a non-cell autonomous role in signalling normal development of the limbs and possibly sternum.

Reelin, the Extracellular Matrix Protein Deficient in Reeler Mutant Mice, Is Processed by a Metalloproteinase

1999 ◽  
Vol 156 (1) ◽  
pp. 214-217 ◽  
Author(s):  
Catherine Lambert de Rouvroit ◽  
Vinciane de Bergeyck ◽  
Caroline Cortvrindt ◽  
Isabelle Bar ◽  
Yves Eeckhout ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Matrix Protein ◽  
Mutant Mice ◽  
Extracellular Matrix Protein ◽  
Reeler Mutant

Biochemical comparison of brain glycosaminoglycans between normal and reeler mutant mice

1993 ◽  
Vol 16 (4) ◽  
pp. 287-292 ◽  
Author(s):  
Fumiko Matsui ◽  
Atsuhiko Oohira ◽  
Ryujiro Shoji ◽  
Yutaka Kariya ◽  
Keiichi Yoshida
Keyword(s):  
Mutant Mice ◽  
Reeler Mutant ◽  
Biochemical Comparison

Somatosensory cortical barrels and thalamic barreloids in reeler mutant mice

Neuroscience ◽  
1977 ◽  
Vol 2 (5) ◽  
pp. 755-766 ◽  
Author(s):  
Carol Welt ◽  
D.A. Steindler
Keyword(s):  
Mutant Mice ◽  
Reeler Mutant

Mutant Mice Lacking Crk-II Caused by the Gene Trap Insertional Mutagenesis: Crk-II Is Not Essential for Embryonic Development

1999 ◽  
Vol 266 (2) ◽  
pp. 569-574 ◽  
Author(s):  
Takashi Imaizumi ◽  
Kimi Araki ◽  
Katsutaka Miura ◽  
Masatake Araki ◽  
Misao Suzuki ◽  
...  
Keyword(s):  
Embryonic Development ◽  
Insertional Mutagenesis ◽  
Gene Trap ◽  
Mutant Mice
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