Cone cells fail to develop normally in transgenic mice showing ablation of rod photoreceptor cells

1994 ◽  
Vol 275 (1) ◽  
pp. 79-90 ◽  
Author(s):  
Jiro Usukura ◽  
Wilson Khoo ◽  
Thoru Abe ◽  
Martin L. Breitman ◽  
Toshimichi Shinohara
Keyword(s):  
Transgenic Mice ◽  
Photoreceptor Cells ◽  
Rod Photoreceptor ◽  
Cone Cells

Abnormal Development of Cone Cells in Transgenic Mice Ablated of Rod Photoreceptor Cells

1993 ◽  
Vol 707 (1 Molecular Bas) ◽  
pp. 550-553 ◽  
Author(s):  
JIRO USUKURA ◽  
WILSON KHOO ◽  
THORU ABE ◽  
TOSHIMICHI SHINOHARA ◽  
MARTIN BREITMAN
Keyword(s):  
Transgenic Mice ◽  
Photoreceptor Cells ◽  
Abnormal Development ◽  
Rod Photoreceptor ◽  
Cone Cells

Genetic ablation of rod photoreceptor cells in transgenic mice

1991 ◽  
Vol 16 ◽  
pp. 79
Author(s):  
Jiro Usukura ◽  
Martin Breitman ◽  
Toshimichi Shinohara
Keyword(s):  
Transgenic Mice ◽  
Photoreceptor Cells ◽  
Rod Photoreceptor ◽  
Genetic Ablation

Calbindin D-28K immunoreactivity of human cone cells varies with retinal position

1995 ◽  
Vol 12 (2) ◽  
pp. 301-307 ◽  
Author(s):  
Tammie L. Haley ◽  
Roland Pochet ◽  
Larry Baizer ◽  
Miriam D. Burton ◽  
John W. Crabb ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Photoreceptor Cells ◽  
Rod Photoreceptor ◽  
Amino Acid Sequence Analysis ◽  
Retinal Position ◽  
Partial Amino Acid Sequence ◽  
Retinal Tissue ◽  
Cone Cells ◽  
The One ◽  
Calbindin D

AbstractCalbindin D-28K is a calcium-binding protein found in the cone but not rod photoreceptor cells in the retinas of a variety of species. Recent studies of the monkey retina indicated that calbindin D-28K may be expressed preferentially in non-foveal regions of the retina. In the current studies of human retinas, immunohistochemical experiments demonstrated that calbindin D-28K is reduced or absent in the fovea and parafovea, but prevalent in the perifovea and periphery. These findings were supported by the quantification of calbindin D-28K in 1-mm trephine punches obtained from different regions of the human retina. The specificity of the anti-calbindin D-28K antibodies used in these studies was confirmed by Western blot analysis using purified calbindin D-28K. The protein was purified from retinal tissue and its identity confirmed by partial amino-acid sequence analysis. The expression of calbindin D-28K did not correlate with the spectral properties of the cones, rather to their position in the retina. The study of spatially expressed genes, like the one encoding calbindin D-28K, may help explain the patterns of retinal degeneration seen in some human cone-rod dystrophies.

Spindle shaped bodies in foveolar cones of the baboon retina

1989 ◽  
Vol 47 ◽  
pp. 960-961
Author(s):  
W. Krebs ◽  
I. Krebs
Keyword(s):  
Cross Sections ◽  
Inclusion Bodies ◽  
Photoreceptor Cells ◽  
Papio Anubis ◽  
Retinal Photoreceptor ◽  
Age Related ◽  
Cone Cells ◽  
Membrane Bound ◽  
Oriented Parallel ◽  
Shaped Inclusion

Various inclusion bodies occur in vertebrate retinal photoreceptor cells. Most of them are membrane bound and associated with phagocytosis or they are age related residual bodies. We found an additional inclusion body in foveal cone cells of the baboon (Papio anubis) retina.The eyes of a 15 year old baboon were fixed by immersion in cacodylate buffered glutaraldehyde (2%)/formaldehyde (2%) as described in detail elsewhere . Pieces of retina from various locations, including the fovea, were embedded in epoxy resin such that radial or tangential sections could be cut.Spindle shaped inclusion bodies were found in the cytoplasm of only foveal cones. They were abundant in the inner segments, close to the external limiting membrane (Fig. 1). But they also occurred in the outer fibers, the perikarya, and the inner fibers (Henle’s fibers) of the cone cells. The bodies were between 0.5 and 2 μm long. Their central diameter was 0.2 to 0. 3 μm. They always were oriented parallel to the long axis of the cone cells. In longitudinal sections (Figs. 2,3) they seemed to have a fibrous skeleton that, in cross sections, turned out to consist of plate-like (Fig.4) and tubular profiles (Fig. 5).

Ayurvedic management of Retinitis Pigmentosa (Doshandha) - A Case Study

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Anju D. ◽  
Pushpa Raj Poudel ◽  
Ajoy Viswam ◽  
Ashwini M. J.
Keyword(s):  
Retinitis Pigmentosa ◽  
Low Vision ◽  
Symptomatic Relief ◽  
Retinal Dystrophy ◽  
Treatment Protocol ◽  
Signs And Symptoms ◽  
Photoreceptor Cells ◽  
Rod Photoreceptor ◽  
Night Time ◽  
Initial Symptoms

Retinitis pigmentosa (RP) is an inherited, degenerative eye disease that causes severe vision impairment due to the progressive degeneration of rod photoreceptor cells in retina. This form of retinal dystrophy manifests initial symptoms independentof age; thus, RP diagnosis occurs anywhere from early infancy to late adulthood. This primary pigmentary retinal dystrophy is a hereditary disorder predominantly affecting the rods more than the cones. The main classical triads of retinitis pigmentosa are arteriolar attenuation, Retinal bone spicule pigmentation and Waxy disc pallor. The main treatment of retinitis pigmentosa is by using Low vision aids (LVA) and Genetic counseling. As such a complete cure for retinitis pigmentosa is not present. So a treatment protocol has to be adopted that helps in at least the symptomatic relief. In Ayurveda, the signs and symptoms of this can be compared with the Lakshanas of Doshandha which is one among the Dristigata Roga. It is considered as a diseased condition in which sunset will obliterate the Dristi Mandala and makes the person blind at night time. During morning hours the rising sunrays will disperse the accumulated Dosas from Dristi to clear vision. This disease resembles Kaphajatimira in its pathogenesis, but the night blindness is the special feature. Since the disease is purely Kaphaja, a treatment attempt is planned in Kaphara and Brimhana line. The present paper discusses a case of retinitis pigmentosa and it’s Ayurvedic Treatment.

scholarly journals Radioimmunocytochemical localization of retinal S-antigen with monoclonal antibodies.

1984 ◽  
Vol 32 (8) ◽  
pp. 834-838 ◽  
Author(s):  
N D Das ◽  
R J Ulshafer ◽  
Z S Zam ◽  
V R Leverenz ◽  
H Shichi
Keyword(s):  
Monoclonal Antibodies ◽  
Outer Segment ◽  
Antigenic Site ◽  
Photoreceptor Cells ◽  
Apical Region ◽  
Rod Photoreceptor ◽  
Inner Limiting Membrane ◽  
Silver Grains ◽  
Homogeneous Preparation ◽  
Labeling Pattern

Two monoclonal antibodies (RSA1/83 and RSA2/83) were developed against a homogeneous preparation of bovine retinal S-antigen. The two hybridomas produced by mouse X mouse hybrid myeloma cells secrete immunoglobulin G. Indirect autoradiography on glutaraldehyde-fixed preparations of bovine explants was used to locate the antigenic site. Antibody RSA1/83 recognizes the antigen primarily in the apical region of the rod outer segment, while antibody RSA2/83 located the antigen both in the outer and inner segments of the rod photoreceptor cells. A distinct band of silver grains also appeared along the inner limiting membrane with both antibodies. Control explants showed no specific labeling pattern over the various retinal compartments.

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