Localization of binding sites for atrial natriuretic factor and angiotensin II in the central nervous system of the clawed toad Xenopus laevis

1992 ◽  
Vol 267 (2) ◽  
pp. 365-373 ◽  
Author(s):  
Werner Kloas ◽  
Wilfried Hanke
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Angiotensin Ii ◽  
Xenopus Laevis ◽  
Binding Sites ◽  
Atrial Natriuretic Factor ◽  
Natriuretic Factor ◽  
The Central Nervous System ◽  
Atrial Natriuretic

Localization of atrial natriuretic factor (ANF) binding sites in the central nervous system of the frog

1989 ◽  
Vol 281 (3) ◽  
pp. 384-396 ◽  
Author(s):  
Yiai Tong ◽  
Pierre Netchitaïlo ◽  
Françlois Leboulenger ◽  
Hubert Vaudry ◽  
Georges Pelletier
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Binding Sites ◽  
Atrial Natriuretic Factor ◽  
Natriuretic Factor ◽  
The Central Nervous System ◽  
Atrial Natriuretic

Atrial natriuretic factor-like immunoreactivity in the central nervous system of the frog

Neuroscience ◽  
1987 ◽  
Vol 22 (1) ◽  
pp. 341-359 ◽  
Author(s):  
P. Netchitailo ◽  
M. Feuilloley ◽  
G. Pelletier ◽  
F. Leboulenger ◽  
M. Cantin ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Atrial Natriuretic Factor ◽  
Natriuretic Factor ◽  
The Central Nervous System ◽  
Atrial Natriuretic

Distinct localization of atrial natriuretic factor and angiotensin II binding sites in the glomerulus

1986 ◽  
Vol 251 (4) ◽  
pp. F594-F602 ◽  
Author(s):  
C. Bianchi ◽  
J. Gutkowska ◽  
G. Thibault ◽  
R. Garcia ◽  
J. Genest ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Comparative Study ◽  
Binding Sites ◽  
Atrial Natriuretic Factor ◽  
Mesangial Cells ◽  
Ang Ii ◽  
Half Maximum ◽  
Natriuretic Factor ◽  
Glomerular Size ◽  
Atrial Natriuretic

A comparative study of the localization of 125I-labeled atrial natriuretic factor (ANF) and 125I-labeled angiotensin II (ANG II) binding sites in the glomerulus of the rat, after an intravascular injection, has been done by ultrastructural radioautography. 125I-ANF binding sites are localized predominantly on the podocytes of the visceral epithelium (63%) followed by the endothelium of capillaries (14%), the parietal epithelium (13%), and finally mesangial cells (10%). In a comparative study, it was confirmed that 125I-ANG II uptake is localized predominantly on mesangial cells (60%) followed by epithelial visceral cells (23%) and the endothelium of capillaries (16%). Using isolated rat glomeruli, it was confirmed that ANG II decreases glomerular size (maximum effect of 15%) with an apparent half maximum effective concentration (EC50) between 10(-9) and 10(-8) M. Although ANF alone has no apparent effect on glomerular size, it inhibits the contractile effect of ANG II with a half maximum inhibitory concentration (IC50) between 10(-11) and 10(-10) M. These results suggest that an intraglomerular mechanism other than glomerular arteriolar resistance may be involved in the modulation of glomerular filtration rate by ANF. The presence of 125I-ANF uptake mainly in foot processes of visceral epithelial cells of glomeruli in vivo and the inhibition of ANG II decrease in glomerular size by ANF in vitro raise the possibility that ANF may regulate the ultrafiltration coefficient by two mechanisms: modulation of glomerular permeability, and surface area.

Sign in / Sign up

Export Citation Format

Share Document