Reduction of tumor necrosis factor ? and interleukin-1? levels in human synovial tissue by interleukin-4 and glucocorticoid

1992 ◽  
Vol 12 (6) ◽  
pp. 217-220 ◽  
Author(s):  
A. Bendrups ◽  
A. Hilton ◽  
A. Meager ◽  
J. A. Hamilton
2003 ◽  
Vol 48 (2) ◽  
pp. 339-347 ◽  
Author(s):  
Leo A. B. Joosten ◽  
Timothy R. D. Radstake ◽  
Erik Lubberts ◽  
Liduine A. M. van den Bersselaar ◽  
Piet L. C. M. van Riel ◽  
...  

Diabetes ◽  
1993 ◽  
Vol 42 (7) ◽  
pp. 1026-1031 ◽  
Author(s):  
K. Yamada ◽  
N. Takane ◽  
S. Otabe ◽  
C. Inada ◽  
M. Inoue ◽  
...  

Author(s):  
Mohamed S. El-Tamawy ◽  
Maha A. Zaki ◽  
Laila A. Rashed ◽  
Eman H. Esmail ◽  
Shaimaa Shaheen Mohamed ◽  
...  

Abstract Background Idiopathic intracranial hypertension (IIH) is a neurological disorder of unknown pathophysiology with many proposed theories that involve CSF dynamics but recently, involvement of inflammatory and autoimmune processes has been postulated. Objectives To investigate presence of oligoclonal bands (OCB) in cerebrospinal fluid (CSF) and serum cytokine level in patients with IIH. Methods This study was conducted on 27 IIH female patients and 21 age- and sex-matched control groups. Patient and control groups were subjected to measurement of interleukin-4 (IL-4), IL-10, and tumor necrosis factor α (TNF-α) levels in serum, and CSF oligoclonal bands was measured in the IIH patient group. Body mass index (BMI) was measured to both patients and control. Results Serum levels of IL-4, IL-10, and TNF alpha were significantly higher in IIH patients than controls (p <  0.001); 22% of IIH patients had positive OCB in CSF. There was a statistically significant difference regarding TNF-α level in OCB-positive and OCB-negative patients being higher in positive patients. No statistically significant correlation was found between serum levels of IL-4, IL-10, TNF-α, and BMI. Conclusion Autoimmune inflammatory process may play a role in pathophysiology of IIH.


Immunity ◽  
2015 ◽  
Vol 43 (6) ◽  
pp. 1125-1136 ◽  
Author(s):  
Nelson C. Di Paolo ◽  
Shahin Shafiani ◽  
Tracey Day ◽  
Thalia Papayannopoulou ◽  
David W. Russell ◽  
...  

1992 ◽  
Vol 63 (1) ◽  
pp. 23-27 ◽  
Author(s):  
Shreemanta K. Parida ◽  
Georges E. Grau ◽  
S.Ahmed Zaheer ◽  
Rama Mukherjee

1990 ◽  
Vol 37 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Ralf Schindler ◽  
Gerhard Lonnemann ◽  
Stanley Shaldon ◽  
Karl-M. Koch ◽  
Charles A. Dinarello

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