Biomechanical changes of the lumbar intervertebral disc after automated and nonautomated percutaneous discectomy: an in vitro investigation

1992 ◽  
Vol 1 (2) ◽  
pp. 96-99 ◽  
Author(s):  
W. H. M. Castro ◽  
J. Jerosch ◽  
J. Rondhuis ◽  
H. Halm ◽  
P. Brinckmann
Keyword(s):  
Intervertebral Disc ◽  
Lumbar Intervertebral Disc ◽  
Percutaneous Discectomy ◽  
In Vitro Investigation ◽  
Biomechanical Changes

Effect of limited nutrition on intervertebral disc health: an in vitro investigation on whole organ disc explants with endplates

2006 ◽  
Vol 39 ◽  
pp. S26-S27
Author(s):  
B. Gantenbein ◽  
S. Jünger ◽  
T. Grünhagen ◽  
C.R. Lee ◽  
C.C. van Donkelaar ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
In Vitro Investigation

Effect of Needle Puncture Injury on Human Intervertebral Disc Mechanics

2010 ◽  
Author(s):  
Raghu N. Natarajan ◽  
Alejandro Espinoza ◽  
Gunnar B. J. Andersson
Keyword(s):  
Animal Models ◽  
Intervertebral Disc ◽  
Lumbar Disc ◽  
Large Animal ◽  
Needle Puncture ◽  
Lumbar Intervertebral Disc ◽  
Model Studies ◽  
Large Animal Models ◽  
Need To Evaluate

Diagnosis, repair and regeneration of the disc often necessitate needle injection to the nucleus pulposus through the annulus. Discography in which a radio opaque material is injected into the nucleus and electrothermal treatment involving inserting a catheter into the disc requires disruption of the annulus through needle puncture. Annulus puncture may also be required during placement of nucleus implants. Needle puncture is also used to inject growth factors, gene and cell therapy for regeneration of the disc. In animal models, disc degeneration is induced over time by needle puncture of the annulus. The severity of the degeneration depends on the magnitude of the annulus needle puncture. One thing that is not clear is how much of the observed changes in the disc biomechanics and biochemical changes are due to nucleus treatment and how much is due to annular disruption through needle puncture. Animal model studies have shown that significant changes in disc mechanics were noticed within 1 week of needle puncture with a large-gauge needle. Another in-vitro animal study showed that biomechanical changes were observed in the disc when the ratio of needle diameter to disc height is greater than 40%. All these studies were focused on the effect of small number of needle diameters and addressed using animal cadaver models. How these needle puncture injury studies on small and large animal models can be extrapolated to human conditions is still not known. Thus there is need to evaluate effect of range of needle puncture diameters in human lumbar disc biomechanics. The purpose of this study is, with the help of a finite element models, quantify the biomechanical effect due to varying size of needle punctures in a human lumbar intervertebral disc.

THE HISTOLOGICAL LOCALIZATION OF FasL mRNA IN HUMAN LUMBAR DISC TISSUE

2006 ◽  
Vol 10 (02) ◽  
pp. 89-94
Author(s):  
Fagang Ye ◽  
Chunxiang Si ◽  
Yujin Qiu ◽  
Bohua Chen ◽  
Zhenhua Lu ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Lumbar Disc ◽  
In Vitro Transcription ◽  
Lumbar Intervertebral Disc ◽  
Degenerative Disc ◽  
Disc Cells ◽  
One Step ◽  
Notochord Cells ◽  
Fasl Mrna

Lumbar disc has become a degenerative tissue since teenage. Apoptosis plays an important role in the processes of degeneration. FasL, a ligand of Fas receptor (a trans-membrane protein) promote signal transduction of apoptosis. In this study, fetal disc and degenerative disc from adults were examined for FasL mRNA expression. hPBMC was first treated by PHA-P, a fragment of FasL cDNA was then synthesized through one-step RT-PCR. Verified by sequencing and recombinant plasmids linearizing, the DIG-cRNA probe was synthesized by in vitro transcription. The distribution of FasL mRNA was observed on lumbar intervertebral disc specimens using in situ hybridization. FasL mRNA signals were expressed in both notochord cells and chondrocyte-like cells in the nucleus of fetal discs. In degenerative disc, the quantity of intervertebral disc cells reduced dramatically and the expression of FasL mRNA was not detected. Expression of FasL in fetal disc implied that Fas/FasL triggered cell death signal pathway involved in lumbar disk transition and degeneration.

In vitro investigation of biomechanical changes of the hip after Salter pelvic osteotomy

2008 ◽  
Vol 23 (3) ◽  
pp. 299-304 ◽  
Author(s):  
R. Pfeifer ◽  
C. Hurschler ◽  
S. Ostermeier ◽  
H. Windhagen ◽  
T. Pressel
Keyword(s):  
Pelvic Osteotomy ◽  
In Vitro Investigation ◽  
Biomechanical Changes

scholarly journals Intervertebral Disc and Adipokine Leptin—Loves Me, Loves Me Not

2020 ◽  
Vol 22 (1) ◽  
pp. 375
Author(s):  
Goran Curic
Keyword(s):  
Adipose Tissue ◽  
Intervertebral Disc ◽  
Nutrient Deficiency ◽  
Protective Role ◽  
Lumbar Intervertebral Disc ◽  
Metabolic Role ◽  
Ivd Degeneration ◽  
Negative Connotation

Leptin—the most famous adipose tissue-secreted hormone—in the human body is mostly observed in a negative connotation, as the hormone level increases with the accumulation of body fat. Nowadays, fatness is becoming another normal body shape. Fatness is burdened with numerous illnesses—including low back pain and degenerative disease of lumbar intervertebral disc (IVD). IVD degeneration and IVD inflammation are two indiscerptible phenomena. Irrespective of the underlying pathophysiological background (trauma, obesity, nutrient deficiency), the inflammation is crucial in triggering IVD degeneration. Leptin is usually depicted as a proinflammatory adipokine. Many studies aimed at explaining the role of leptin in IVD degeneration, though mostly in in vitro and on animal models, confirmed leptin’s “bad reputation”. However, several studies found that leptin might have protective role in IVD metabolism. This review examines the current literature on the metabolic role of different depots of adipose tissue, with focus on leptin, in pathogenesis of IVD degeneration.

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