Identification of a macromolecular crystal growth inhibitor in human urine as osteopontin

1995 ◽  
Vol 23 (5) ◽  
pp. 327-334 ◽  
Author(s):  
S. S�rensen ◽  
S. J. Justesen ◽  
A. H. Johnsen
Keyword(s):  
Crystal Growth ◽  
Human Urine ◽  
Growth Inhibitor

Alkyl-chain disorder in tetraisohexylammonium bromide

2012 ◽  
Vol 68 (4) ◽  
pp. o152-o155 ◽  
Author(s):  
Malcolm A. Kelland ◽  
Amber L. Thompson
Keyword(s):  
Crystal Structure ◽  
Crystal Growth ◽  
Alkyl Chain ◽  
Growth Inhibitor ◽  
Ammonium Cation ◽  
Asymmetric Unit ◽  
Bromide Anion ◽  
Alkyl Chains ◽  
Hydrate Crystal ◽  
Structure Ii Clathrate Hydrate

Tetraisohexylammonium bromide [systematic name: tetrakis(4-methylpentyl)azanium bromide], C24H52N+·Br−, is a powerful structure II clathrate hydrate crystal-growth inhibitor. The crystal structure, in the space groupP3221, contains one ammonium cation and one bromide anion in the asymmetric unit, both on general positions. At 100 K, the ammonium cation exhibits one ordered isohexyl chain and three disordered isohexyl chains. At 250 K, all four isohexyl chains are disordered. In an effort to reduce the disorder in the alkyl chains, the crystal was thermally cycled, but the disorder remained, indicating that it is dynamic in nature.

Mannan-binding lectin (MBL)-associated plasma protein present in human urine inhibits calcium oxalate crystal growth

FEBS Letters ◽  
1999 ◽  
Vol 462 (1-2) ◽  
pp. 89-93 ◽  
Author(s):  
Insug Kang ◽  
Jin-Il Kim ◽  
Sung-Goo Chang ◽  
Sun-Ju Lee ◽  
Sang-Lim Choi ◽  
...  
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Plasma Protein ◽  
Human Urine ◽  
Calcium Oxalate Crystal ◽  
Mannan Binding Lectin ◽  
Binding Lectin

An unidentified macromolecular inhibitory constituent of calcium oxalate crystal growth in human urine

1990 ◽  
Vol 18 (6) ◽  
pp. 373-379 ◽  
Author(s):  
S. S�rensen ◽  
K. Hansen ◽  
S. Bak ◽  
S. J. Justesen
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Calcium Oxalate Crystal

Acidic peptide and polyribonucleotide crystal growth inhibitors in human urine

1977 ◽  
Vol 233 (5) ◽  
pp. F455-F463 ◽  
Author(s):  
H. Ito ◽  
F. L. Coe
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Human Urine ◽  
Gel Filtration ◽  
Subsequent Treatment ◽  
Calcium Oxalate Crystal ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Acidic Peptide ◽  
Gastric Pepsin

Urine contains nondialyzable inhibitors of calcium oxalate crystal growth. We have pursued the hypothesis that these inhibitors may, in part, be acidic peptides and polyribonucleotide fragments. Homopolyribonucleotides and RNA inhibit calcium oxalate crystal growth at 5 x 10(-6) M of constituent ribonucleotide, whereas the monomer nucleotides are inactive at 10(-4) M. Poly-L-aspartic or glutamic acid are also inhibitory at 5 X 10(-6) M of amino acid, whereas the monomeric amino acids are inert. Gastric pepsin, a naturally occurring acidic peptide, is inhibitory. Incubation with nonspecific protease reduced the inhibitory effectiveness of normal human urine consistently and significantly, a fact compatible with an important contribution of peptides. A variable additional reduction was produced by subsequent treatment with ribonuclease, suggesting only a small role for polyribonucleotide. Sequential ion exchange and gel filtration chromatography and preparative disc gel electrophoresis yielded inhibitory material enriched with peptides that were strongly acidic and high in proline. Peptides and ribonucleotides seem to contribute to urinary nondialyzable crystal growth inhibitory activity.

Isolation of calcium oxalate crystal growth inhibitor from rat kidney and urine

1984 ◽  
Vol 247 (5) ◽  
pp. F765-F772 ◽  
Author(s):  
Y. Nakagawa ◽  
V. Abram ◽  
F. L. Coe
Keyword(s):  
Crystal Growth ◽  
Calcium Oxalate ◽  
Column Chromatography ◽  
Dissociation Constants ◽  
Rat Kidney ◽  
Deae Cellulose ◽  
Growth Inhibitor ◽  
Calcium Oxalate Monohydrate ◽  
Heat Denaturation ◽  
Kidney Homogenate

Glycoproteins that slow the growth rate of calcium oxalate monohydrate crystals were purified from rat kidney homogenate and urine by selective heat denaturation (for rat kidney homogenate), DEAE-cellulose column chromatography, and gel permeation column chromatography. Both kidney and urine inhibitors were glycoproteins with an apparent mol wt of 1.4 X 10(4), as determined by high-performance liquid chromatography. They contained gamma-carboxyglutamic acid and a high percentage of aspartic acid and glutamic acid but had few aromatic amino acid residues. Both inhibitors contained fucose, mannose, glucose, galactose, glucosamine, galactosamine, and N-acetylneuraminic acid but no glucuronic acid. Kinetic studies suggest that purified inhibitors bind to calcium oxalate monohydrate seed crystals according to a Langmuir adsorption isotherm with similar dissociation constants of 14 X 10(-8)M for rat urine inhibitor and 8.7 X 10(-8) M for rat kidney inhibitor. The isolation of similar glycoproteins from kidney and urine suggests that urinary crystal growth inhibitor may be produced in the kidneys.

Fast Formation of Biomimetic Ca-P Coatings on Ti6Al4V

1999 ◽  
Vol 599 ◽  
Author(s):  
F. Barrère ◽  
P. Layrolle ◽  
C. A. van Blitterswijk ◽  
K. de Groot
Keyword(s):  
Crystal Growth ◽  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Photoelectron Spectroscopy ◽  
Body Fluid ◽  
Growth Inhibitor ◽  
Passive Layer ◽  
Chemical Bonds ◽  
X Ray ◽  
Coating Formation

AbstractThe aim of this study was to accelerate the formation of biomimetic Calcium-Phosphate (Ca-P) coatings on Ti6Al4V by using a 5 times more concentrated Simulated Body Fluid (SBFx5) than the regular SBF. The production of SBFx5 was possible by decreasing the pH of the solution to approximately 6 with CO2 gas. The release of this mildly acidic gas allowed the formation of a Ca-P film after 4h of immersion at pH=6.8. The structure of this coating was an amorphous carbonated Ca-P. In addition, our experiments showed that the presence of Mg2+ was absolutely necessary for the Ca-P coating formation on Ti6Al4V substrate. Mg2+ is a crystal growth inhibitor and favored the heterogeneous nucleation. Furthermore, depth profile X-Ray Photoelectron Spectroscopy showed that Ca-P nucleation on the passive Titanium oxide (TiO2) passive layer was initiated by Ca2+ and Mg2+. The attachment of this Ca-P coating resulted probably from chemical bonds such as P-O-Ti and Ca-O-Ti. Ca was more present at the coating/substrate interface than P. Thereby Ca-O-Ti seems to be favored.

A simple and effective crystal growth inhibitor for high performance solid-state dye-sensitized solar cells

RSC Advances ◽  
2016 ◽  
Vol 6 (79) ◽  
pp. 75138-75143 ◽  
Author(s):  
Xiangguo Wang ◽  
Ying Su ◽  
Yun Wang ◽  
Hao Sun ◽  
Jie Zhao ◽  
...  
Keyword(s):  
Ionic Liquids ◽  
Solar Cells ◽  
Crystal Growth ◽  
Solid State ◽  
High Performance ◽  
Dye Sensitized Solar Cells ◽  
Growth Inhibitor ◽  
Dye Sensitized ◽  
Sensitized Solar Cells

Three simple imidazolium-type ionic liquids with benzene cores (abbreviated as [TMImB][Br] and [TMImB][TFSI]) have been successfully designed, synthesized and characterized.

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