scholarly journals Human growth hormone response to a fall in plasma glucose concentration in normal and diabetic subjects

Diabetologia ◽  
1983 ◽  
Vol 24 (2) ◽  
pp. 136-137 ◽  
Author(s):  
E. O. Grecu ◽  
R. M. Walter
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Plasma Glucose ◽  
Glucose Concentration ◽  
Human Growth ◽  
Growth Hormone Response ◽  
Plasma Glucose Concentration ◽  
Hormone Response

Human growth hormone response to repeated bouts of aerobic exercise

1997 ◽  
Vol 83 (5) ◽  
pp. 1756-1761 ◽  
Author(s):  
J. A. Kanaley ◽  
J. Y. Weltman ◽  
J. D. Veldhuis ◽  
A. D. Rogol ◽  
M. L. Hartman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Aerobic Exercise ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Exercise Bout ◽  
Cycle Ergometer ◽  
Distribution Volume ◽  
Growth Hormone Response ◽  
Hormone Response ◽  
Deconvolution Analysis

Kanaley, J. A., J. Y. Weltman, J. D. Veldhuis, A. D. Rogol, M. L. Hartman, and A. Weltman. Human growth hormone response to repeated bouts of aerobic exercise. J. Appl. Physiol. 83(5): 1756–1761, 1997.—We examined whether repeated bouts of exercise could override growth hormone (GH) auto-negative feedback. Seven moderately trained men were studied on three occasions: a control day (C), a sequential exercise day (SEB; at 1000, 1130, and 1300), and a delayed exercise day (DEB; at 1000, 1400, and 1800). The duration of each exercise bout was 30 min at 70% maximal O2 consumption (V˙o 2 max) on a cycle ergometer. Standard meals were provided at 0600 and 2200. GH was measured every 5–10 min for 24 h (0800–0800). Daytime (0800–2200) integrated GH concentrations were ∼150–160% greater during SEB and DEB than during C: 1,282 ± 345, 3,192 ± 669, and 3,389 ± 991 min ⋅ μg ⋅ l−1for C, SEB, and DEB, respectively [SEB > C ( P < 0.06), DEB > C ( P < 0.03)]. There were no differences in GH release during sleep (2300–0700). Deconvolution analysis revealed that the increase in 14-h integrated GH concentration on DEB was accounted for by an increase in the mass of GH secreted per pulse (per liter of distribution volume, lv): 7.0 ± 2.9 and 15.9 ± 2.6 μg/lv for C and DEB, respectively ( P < 0.01). Comparison of 1.5-h integrated GH concentrations on the SEB and DEB days (30 min exercise + 60 min recovery) revealed that, with each subsequent exercise bout, GH release apparently increased progressively, with a slightly greater increase on the DEB day [SEB vs. DEB: 497 ± 162 vs. 407 ± 166 ( bout 1), 566 ± 152 vs. 854 ± 184 ( bout 2), and 633 ± 149 vs. 1,030 ± 352 min ⋅ μg ⋅ l−1( bout 3), P < 0.05]. We conclude that the GH response to acute aerobic exercise is augmented with repeated bouts of exercise.

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