scholarly journals Glucose-induced insulin response and insulin sensitivity is not related to HLA-type but to age in young siblings of Type 1 (insulin-dependent) diabetic patients

Diabetologia ◽  
1987 ◽  
Vol 30 (9) ◽  
pp. 727-732 ◽  
Author(s):  
F. Lindgren ◽  
G. Dahlquist ◽  
S. Efendic' ◽  
E. M�ller ◽  
B. Persson ◽  
...  
Diabetologia ◽  
1986 ◽  
Vol 29 (6) ◽  
pp. 358-361 ◽  
Author(s):  
K. Hermansen ◽  
O. Rasmussen ◽  
J. Arnfred ◽  
E. Winther ◽  
O. Schmitz

1987 ◽  
Vol 72 (1) ◽  
pp. 123-130 ◽  
Author(s):  
J. Kastrup ◽  
T. Nørgaard ◽  
H.-H. Parving ◽  
N. A. Lassen

1. The distensibility of the resistance vessels of the skin at the dorsum of the foot was determined in 11 long-term type 1 (insulin-dependent) diabetic patients with nephropathy and retinopathy, nine short-term type 1 diabetic patients without clinical microangiopathy and in nine healthy non-diabetic subjects. 2. Blood flow was measured by the local 133Xexenon washout technique in a vascular bed locally paralysed by the injection of histamine. Blood flow was measured before, during and after a 40 mmHg increase of the vascular transmural pressure, induced by head-up tilt. 3. The mean increase in blood flow during headup tilt was only 24% in diabetic subjects with and 48% in diabetic patients without clinical microangiopathy, compared with 79% in normal non-diabetic subjects (P < 0.0005 and P < 0.05, respectively). 4. An inverse correlation between microvascular distensibility and degree of hyalinosis of the terminal arterioles in biopsies from the skin was demonstrated (r = − 0.57, P < 0.001). 5. Our results suggest that terminal arteriolar hyalinosis reduces the microvascular distensibility and probably increases the minimal vascular resistance, thereby impeding hyperaemic responses.


Diabetologia ◽  
1983 ◽  
Vol 24 (4) ◽  
Author(s):  
G. Pozza ◽  
J. Traeger ◽  
J.M. Dubernard ◽  
A. Secchi ◽  
A.E. Pontiroli ◽  
...  

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