Stimulated pressure response of the ileocolonic junctional zone and its use as a continence mechanism in a canine model

1993 ◽  
Vol 21 (5) ◽  
pp. 333-337 ◽  
Author(s):  
Rainer Hofmann ◽  
Reynaldo Gomez ◽  
Marshall L. Stoller ◽  
Emil A. Tanagho ◽  
Jack W. McAninch
Keyword(s):  
Canine Model ◽  
Pressure Response ◽  
Junctional Zone ◽  
Continence Mechanism

Motility and intraluminal pressure of the ileocolonic junctional zone and adjacent bowel in a canine model

1993 ◽  
Vol 21 (5) ◽  
pp. 329-332 ◽  
Author(s):  
Rainer Hofmann ◽  
Reynaldo Gomez ◽  
Emil A. Tanagho ◽  
Jack W. McAninch
Keyword(s):  
Canine Model ◽  
Intraluminal Pressure ◽  
Junctional Zone

V1540: Potassium-Titanyl-Phosphate (KTP) Laser Nerve-Sparing Laparoscopic Radical Prostatectomy: Effects on Cavernous Nerve Function in a Canine Model

2007 ◽  
Vol 177 (4S) ◽  
pp. 508-509
Author(s):  
Troy R. Gianduzzo ◽  
Jose R. Colombo ◽  
Georges-Pascal Haber ◽  
Kester Nahen ◽  
Cristina Magi-Galluzzi ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Canine Model ◽  
Laparoscopic Radical Prostatectomy ◽  
Potassium Titanyl Phosphate ◽  
Nerve Sparing ◽  
Ktp Laser ◽  
Nerve Function ◽  
Cavernous Nerve

1412: Corporal Cavernosal Apoptosis Following Radical Prostatectomy in the Canine Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 372-372
Author(s):  
Carlumandarlo E.B. Zaramo ◽  
Nina G. Hall ◽  
Rupesh Raina ◽  
Ashok Agarwal ◽  
Inderbir S. Gill ◽  
...  
Keyword(s):  
Radical Prostatectomy ◽  
Canine Model

Comparison of High Purity Factor IX Concentrates and a Prothrombin Complex Concentrate in a Canine Model of Thrombogenicity

1991 ◽  
Vol 66 (05) ◽  
pp. 609-613 ◽  
Author(s):  
I R MacGregor ◽  
J M Ferguson ◽  
L F McLaughlin ◽  
T Burnouf ◽  
C V Prowse
Keyword(s):  
High Purity ◽  
Time Course ◽  
Prothrombin Complex Concentrate ◽  
Degradation Products ◽  
Canine Model ◽  
Factor Ix ◽  
In Vitro Tests ◽  
Albumin Infusion

SummaryA non-stasis canine model of thrombogenicity has been used to evaluate batches of high purity factor IX concentrates from 4 manufacturers and a conventional prothrombin complex concentrate (PCC). Platelets, activated partial thromboplastin time (APTT), fibrinogen, fibrin(ogen) degradation products and fibrinopeptide A (FPA) were monitored before and after infusion of concentrate. Changes in FPA were found to be the most sensitive and reproducible indicator of thrombogenicity after infusion of batches of the PCC at doses of between 60 and 180 IU/kg, with a dose related delayed increase in FPA occurring. Total FPA generated after 100-120 IU/kg of 3 batches of PCC over the 3 h time course was 9-12 times that generated after albumin infusion. In contrast the amounts of FPA generated after 200 IU/kg of the 4 high purity factor IX products were in all cases similar to albumin infusion. It was noted that some batches of high purity concentrates had short NAPTTs indicating that current in vitro tests for potential thrombogenicity may be misleading in predicting the effects of these concentrates in vivo.

The Development of Homologous (Canine/Anti-Canine) Antibodies in Dogs with Haemophilia A (Factor VIII Deficiency): A Ten-Year Longitudinal Study

1993 ◽  
Vol 69 (01) ◽  
pp. 021-024 ◽  
Author(s):  
Shawn Tinlin ◽  
Sandra Webster ◽  
Alan R Giles
Keyword(s):  
Factor Viii ◽  
Canine Model ◽  
Significant Inhibition ◽  
Human Condition ◽  
Haemophilia A ◽  
Variable Expression ◽  
The Family ◽  
Over Time

SummaryThe development of inhibitors to factor VIII in patients with haemophilia A remains as a serious complication of replacement therapy. An apparently analogous condition has been described in a canine model of haemophilia A (Giles et al., Blood 1984; 63:451). These animals and their relatives have now been followed for 10 years. The observation that the propensity for inhibitor development was not related to the ancestral factor VIII gene has been confirmed by the demonstration of vertical transmission through three generations of the segment of the family related to a normal (non-carrier) female that was introduced for breeding purposes. Haemophilic animals unrelated to this animal have not developed functionally significant factor VIII inhibitors despite intensive factor VIII replacement. Two animals have shown occasional laboratory evidence of factor VIII inhibition but this has not been translated into clinical significant inhibition in vivo as assessed by clinical response and F.VIII recovery and survival characteristics. Substantial heterogeneity of inhibitor expression both in vitro and in vivo has been observed between animals and in individual animals over time. Spontaneous loss of inhibitors has been observed without any therapies designed to induce tolerance, etc., being instituted. There is also phenotypic evidence of polyclonality of the immune response with variable expression over time in a given animal. These observations may have relevance to the human condition both in determining the pathogenetic factors involved in this condition and in highlighting the heterogeneity of its expression which suggests the need for caution in the interpretation of the outcome of interventions designed to modulate inhibitor activity.

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