Role of intracellular Ca2+ stores in smooth muscle contractions of the guinea pig vas deferens

1993 ◽  
Vol 21 (5) ◽  
pp. 319-323 ◽  
Author(s):  
P. Drescher ◽  
R. E. Eckert ◽  
P. O. Madsen
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Vas Deferens ◽  
Muscle Contractions ◽  
Smooth Muscle Contractions

scholarly journals Model of influence of AT1, AT2 type receptors on smooth muscle contractions

2020 ◽  
Vol 18 (4) ◽  
pp. 339-343
Author(s):  
K. Yankov ◽  
G. Shivacheva
Keyword(s):  
Differential Equation ◽  
Smooth Muscle ◽  
Angiotensin Ii ◽  
Order Differential Equation ◽  
Transfer Functions ◽  
Muscle Contractions ◽  
State Space Models ◽  
Laplace Domain ◽  
Smooth Muscle Contractions

In the present work, the role of AT1 and AT2 receptors in the performance of angiotensin II-mediated processes has been analyzed. The involvement of each of the receptor types in regulation is determined by their separate exclusion from the feedback chain applying a suitable blocker. The resulting muscle contractions are modeled with a second-order differential equation. The transfer functions in the Laplace domain and state-space models of the contractions are derived from the models. The analysis of the models justifies the determination that AT1 type receptors participate in positive feedback and those of AT2 type in negative.

Role of Ca2+ in vascular smooth muscle contractions induced by Phoneutria nigriventer spider venom

Toxicon ◽  
2004 ◽  
Vol 43 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Cleber E Teixeira ◽  
Alexandre P Corrado ◽  
Gilberto De Nucci ◽  
Edson Antunes
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Contractions ◽  
Spider Venom ◽  
Smooth Muscle Contractions ◽  
Phoneutria Nigriventer

Inhibitory Effect of Sex Steroids on Guinea-Pig Airway Smooth Muscle Contractions

1997 ◽  
Vol 118 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Mercedes Perusquı́a ◽  
Ricardo Hernández ◽  
Luis M Montaño ◽  
Carlos M Villalón ◽  
Marı́a G Campos
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Airway Smooth Muscle ◽  
Sex Steroids ◽  
Inhibitory Effect ◽  
Muscle Contractions ◽  
Smooth Muscle Contractions

Muscarinic receptors on nerves and muscles in opossum esophagus muscularis mucosa

1987 ◽  
Vol 65 (9) ◽  
pp. 1903-1907 ◽  
Author(s):  
E. E. Daniel ◽  
J. Jury ◽  
P. Bowker
Keyword(s):  
Smooth Muscle ◽  
Substance P ◽  
Guinea Pig ◽  
Muscarinic Receptors ◽  
Smooth Muscles ◽  
Muscle Contractions ◽  
Muscularis Mucosa ◽  
Field Stimulation ◽  
Guinea Pig Ileum ◽  
Smooth Muscle Contractions

The muscarinic receptors of muscularis mucosa have some recognition properties that suggest they resemble receptors of the M1 sybtype. The nerves of these tissues also contain muscarinic receptors which inhibit tonic contractions caused by release of a substance-P-like material by field stimulation. These receptors also appear to be M1 in type as they are maximally activated by McNeil A343 as well as by carbachol (pD2, 5.5 and 7.5, respectively). They are also inhibited by pirenzepine, as well as by atropine (negative logarithms of the required dose for 50% inhibition or potentiation, 6.6–6.7 compared with 8.2–8.3). Hexahydrosiladifenidol, an antagonist selective for M2 receptors of guinea pig ileum, had a low (~7.1) pA2 value for antagonism of both agonists in smooth muscle in this tissue. However, it was closer to atropine in potency with respect to potentiating tonic responses to field stimulation or to inhibiting phasic responses to field stimulation than it was to antagonizing smooth muscle contractions. Thus, atropine was about 40 times more potent than pirenzepine and 2–5 times more potent than hexahydrosilafenidol. There were some quantitative differences in the effectiveness of these three antagonists in blocking the phasic (acetylcholine-mediated) response to field stimulation. Atropine was 70–100 times more potent than pirenzepine and 8–25 times more potent than hexahydrosiladifenidol. This greater potency difference for inhibition of phasic contractions compared with potentiation of tonic contractions was discussed. This tissue appears to be one of the first smooth muscles in which both nerves and muscles contain muscarinic receptors with some recognition properties resembling those of the M1 subtype.

scholarly journals The Role of Potassium Ions in the Contraction Process of Smooth Muscle in the Vas Deferens Isolated from Guinea-Pig

1973 ◽  
Vol 25 (2) ◽  
pp. 179-187
Author(s):  
Jiro Sugimoto ◽  
Kazuya Kido ◽  
Ikki Imamura ◽  
Matsusuke Gamou ◽  
Yasukazu Nishikubo ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Vas Deferens ◽  
Potassium Ions ◽  
Contraction Process
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