Enhanced gene expression of transforming growth factor-? and c-met in rat urinary bladder cancer

1996 ◽  
Vol 24 (1) ◽  
pp. 55-60 ◽  
Author(s):  
M. Inui ◽  
N. Nishi ◽  
A. Yasumoto ◽  
I. Takenaka ◽  
H. Miyanaka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Growth Factor ◽  
Urinary Bladder ◽  
Transforming Growth Factor ◽  
Urinary Bladder Cancer ◽  
Rat Urinary Bladder

c.29C>T polymorphism in the transforming growth factor-β1 (TGFB1) gene correlates with increased risk of urinary bladder cancer

Cytokine ◽  
2015 ◽  
Vol 75 (2) ◽  
pp. 344-348 ◽  
Author(s):  
Kirti Amresh Gautam ◽  
Singh Pooja ◽  
Satya Narayan Sankhwar ◽  
Pushp Lata Sankhwar ◽  
Apul Goel ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Growth Factor ◽  
Urinary Bladder ◽  
Transforming Growth Factor ◽  
Urinary Bladder Cancer ◽  
Transforming Growth Factor Β1 ◽  
Increased Risk ◽  
Tgfb1 Gene

scholarly journals Expression and function of transforming growth factor-β isoforms and cognate receptors in the rat urinary bladder following cyclophosphamide-induced cystitis

2013 ◽  
Vol 305 (9) ◽  
pp. F1265-F1276 ◽  
Author(s):  
Eric J. Gonzalez ◽  
Beatrice M. Girard ◽  
Margaret A. Vizzard
Keyword(s):  
Urinary Tract ◽  
Growth Factor ◽  
Urinary Bladder ◽  
Lower Urinary Tract ◽  
Transforming Growth Factor ◽  
Bladder Capacity ◽  
Transforming Growth Factor Β ◽  
Rat Urinary Bladder ◽  
Urinary Bladder Dysfunction ◽  
Lower Urinary

Numerous proinflammatory cytokines have been implicated in the reorganization of lower urinary tract function following cyclophosphamide (CYP)-induced cystitis. The present study investigated the functional profile of three pleiotropic transforming growth factor-β (TGF-β) isoforms and receptor (TβR) variants in the normal and inflamed (CYP-induced cystitis) rat urinary bladder. Our findings indicate that TGF-β (1, 2, and 3) and TβR (1, 2, and 3) transcript and protein expression were regulated to varying degrees in the urothelium or detrusor smooth muscle following intermediate (48 h; 150 mg/kg ip) or chronic (75 mg/kg ip; once every 3 days for 10 days), but not acute (4 h; 150 mg/kg ip), CYP-induced cystitis. Conscious, open-outlet cystometry was performed to determine whether aberrant TGF-β signaling contributes to urinary bladder dysfunction following intermediate (48 h) CYP-induced cystitis. TβR-1 inhibition with SB505124 (5 μM) significantly (p ≤ 0.001) decreased voiding frequency and increased bladder capacity (2.5-fold), void volume (2.6-fold), and intercontraction intervals (2.5-fold) in CYP-treated (48 h) rats. Taken together, these results provide evidence for 1) the involvement of TGF-β in lower urinary tract neuroplasticity following urinary bladder inflammation, 2) a functional role of TGF-β signaling in the afferent limb of the micturition reflex, and 3) urinary bladder TβR-1 as a viable target to reduce voiding frequency with cystitis.

Influence of Cigarette Smoking on Prostaglandin Synthesis and Cyclooxygenase-2 Gene Expression in Human Urinary Bladder Cancer

2002 ◽  
Vol 20 (5-6) ◽  
pp. 651-656 ◽  
Author(s):  
Alaa F. Badawi ◽  
Samy L. Habib ◽  
Mohammed A. Mohammed ◽  
Ahmed A. Abadi ◽  
Michael S. Michael
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Urinary Bladder ◽  
Cigarette Smoking ◽  
Urinary Bladder Cancer ◽  
Prostaglandin Synthesis ◽  
Cyclooxygenase 2 ◽  
Human Urinary Bladder
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